%0 Journal Article %1 AsheryPadan.1999 %A Ashery-Padan, R. %A Alvarez-Bolado, G. %A Klamt, B. %A Gessler, M. %A Gruss, P. %D 1999 %J Mech Dev %K *Drosophila *Gene Acid Alignment Amino Animals Brain/embryology/growth DNA;Complementary/genetics Data Development/genetics Embryonic;Fetal Expression Fetal Glycoproteins/biosynthesis/*genetics/secretion Homology;Amino Membrane Mice/embryology/*genetics/growth Molecular Morphogenesis/genetics Nerve Organ Proteins Proteins/biosynthesis/*genetics/secretion Proteins/biosynthesis/genetics/secretion Regulation;Developmental Sequence Specificity Tissue development development/*metabolism {\&} %N 2 %P 213--217 %T Fjx1, the murine homologue of the Drosophila four-jointed gene, codes for a putative secreted protein expressed in restricted domains of the developing and adult brain %V 80 %X The Drosophila gene four jointed (fj) codes for a secreted or cell surface protein important for growth and differentiation of legs and wings and for proper development of the eyes. Here we report the cloning of the mouse four-jointed gene (fjx1) and its pattern of expression in the brain during embryogenesis and in the adult. In the neural plate, fjx1 is expressed in the presumptive forebrain and midbrain, and in rhombomere 4, however a small rostral/medial area of the forebrain primordium is devoid of expression. Expression of fjx1 in the neural tube can be divided into three phases. (1) In the embryonic brain fjx1 is expressed in two patches of neuroepithelium: in the midbrain tectum and the telencephalic vesicles. (2) In fetal and early postnatal brain fjx1 is expressed mainly by the primordia of layered telencephalic structures: cortex (ventricular layer and cortical plate), olfactory bulb (subependymal layer and in the mitral cell layer). In addition expression is observed in the superior colliculus. (3) In the adult, fjx1 is expressed by neurones evenly distributed in the telencephalon (isocortex, striatum, hippocampus, olfactory bulb, piriform cortex), in the Purkinje cell layer of the cerebellum, and numerous medullary nuclei. In the embryo, strong expression can further be seen in the apical ectodermal ridge of fore- and hindlimbs and in the ectoderm of the branchial arches.

@article{AsheryPadan.1999, abstract = {The Drosophila gene four jointed (fj) codes for a secreted or cell surface protein important for growth and differentiation of legs and wings and for proper development of the eyes. Here we report the cloning of the mouse four-jointed gene (fjx1) and its pattern of expression in the brain during embryogenesis and in the adult. In the neural plate, fjx1 is expressed in the presumptive forebrain and midbrain, and in rhombomere 4, however a small rostral/medial area of the forebrain primordium is devoid of expression. Expression of fjx1 in the neural tube can be divided into three phases. (1) In the embryonic brain fjx1 is expressed in two patches of neuroepithelium: in the midbrain tectum and the telencephalic vesicles. (2) In fetal and early postnatal brain fjx1 is expressed mainly by the primordia of layered telencephalic structures: cortex (ventricular layer and cortical plate), olfactory bulb (subependymal layer and in the mitral cell layer). In addition expression is observed in the superior colliculus. (3) In the adult, fjx1 is expressed by neurones evenly distributed in the telencephalon (isocortex, striatum, hippocampus, olfactory bulb, piriform cortex), in the Purkinje cell layer of the cerebellum, and numerous medullary nuclei. In the embryo, strong expression can further be seen in the apical ectodermal ridge of fore- and hindlimbs and in the ectoderm of the branchial arches.}, added-at = {2013-01-29T13:47:26.000+0100}, author = {Ashery-Padan, R. and Alvarez-Bolado, G. and Klamt, B. and Gessler, M. and Gruss, P.}, biburl = {https://www.bibsonomy.org/bibtex/2e83a268cf6b0568201ba54921b624be0/ebch}, interhash = {052db480b5d89e878411d58ec50cac9b}, intrahash = {e83a268cf6b0568201ba54921b624be0}, journal = {Mech Dev}, keywords = {*Drosophila *Gene Acid Alignment Amino Animals Brain/embryology/growth DNA;Complementary/genetics Data Development/genetics Embryonic;Fetal Expression Fetal Glycoproteins/biosynthesis/*genetics/secretion Homology;Amino Membrane Mice/embryology/*genetics/growth Molecular Morphogenesis/genetics Nerve Organ Proteins Proteins/biosynthesis/*genetics/secretion Proteins/biosynthesis/genetics/secretion Regulation;Developmental Sequence Specificity Tissue development development/*metabolism {\&}}, number = 2, pages = {213--217}, timestamp = {2013-01-29T13:47:39.000+0100}, title = {Fjx1, the murine homologue of the Drosophila four-jointed gene, codes for a putative secreted protein expressed in restricted domains of the developing and adult brain}, volume = 80, year = 1999 }