%0 Journal Article %1 Peris2018 %A Peris, Leticia %A Bisbal, Mariano %A Martinez-Hernandez, José %A Saoudi, Yasmina %A Jonckheere, Julie %A Rolland, Marta %A Sebastien, Muriel %A Brocard, Jacques %A Denarier, Eric %A Bosc, Christophe %A Guerin, Christophe %A Gory-Fauré, Sylvie %A Deloulme, Jean Christophe %A Lanté, Fabien %A Arnal, Isabelle %A Buisson, Alain %A Goldberg, Yves %A Blanchoin, Laurent %A Delphin, Christian %A Andrieux, Annie %D 2018 %I Nature Publishing Group %J Nature Communications %K actin dendrite microtubules neuro plasticity %N 1 %P 1--15 %R 10.1038/s41467-018-05869-z %T A key function for microtubule-associated-protein 6 in activity-dependent stabilisation of actin filaments in dendritic spines %V 9 %X Emerging evidence indicates that microtubule-associated proteins (MAPs) are implicated in synaptic function; in particular, mice deficient for MAP6 exhibit striking deficits in plasticity and cognition. How MAP6 connects to plasticity mechanisms is unclear. Here, we address the possible role of this protein in dendritic spines. We find that in MAP6-deficient cortical and hippocampal neurons, maintenance of mature spines is impaired, and can be restored by expressing a stretch of the MAP6 sequence called Mc modules. Mc modules directly bind actin filaments and mediate activity-dependent stabilisation of F-actin in dendritic spines, a key event of synaptic plasticity. In vitro, Mc modules enhance actin filament nucleation and promote the formation of stable, highly ordered filament bundles. Activity-induced phosphorylation of MAP6 likely controls its transfer to the spine cytoskeleton. These results provide a molecular explanation for the role of MAP6 in cognition, enlightening the connection between cytoskeletal dysfunction, synaptic impairment and neuropsychiatric illnesses.

@article{Peris2018, abstract = {Emerging evidence indicates that microtubule-associated proteins (MAPs) are implicated in synaptic function; in particular, mice deficient for MAP6 exhibit striking deficits in plasticity and cognition. How MAP6 connects to plasticity mechanisms is unclear. Here, we address the possible role of this protein in dendritic spines. We find that in MAP6-deficient cortical and hippocampal neurons, maintenance of mature spines is impaired, and can be restored by expressing a stretch of the MAP6 sequence called Mc modules. Mc modules directly bind actin filaments and mediate activity-dependent stabilisation of F-actin in dendritic spines, a key event of synaptic plasticity. In vitro, Mc modules enhance actin filament nucleation and promote the formation of stable, highly ordered filament bundles. Activity-induced phosphorylation of MAP6 likely controls its transfer to the spine cytoskeleton. These results provide a molecular explanation for the role of MAP6 in cognition, enlightening the connection between cytoskeletal dysfunction, synaptic impairment and neuropsychiatric illnesses.}, added-at = {2020-03-23T21:12:34.000+0100}, author = {Peris, Leticia and Bisbal, Mariano and Martinez-Hernandez, Jos{\'{e}} and Saoudi, Yasmina and Jonckheere, Julie and Rolland, Marta and Sebastien, Muriel and Brocard, Jacques and Denarier, Eric and Bosc, Christophe and Guerin, Christophe and Gory-Faur{\'{e}}, Sylvie and Deloulme, Jean Christophe and Lant{\'{e}}, Fabien and Arnal, Isabelle and Buisson, Alain and Goldberg, Yves and Blanchoin, Laurent and Delphin, Christian and Andrieux, Annie}, biburl = {https://www.bibsonomy.org/bibtex/2f5470f4453b9f9df64061acdc58703a3/kfriedl}, doi = {10.1038/s41467-018-05869-z}, file = {:C$\backslash$:/Users/Karoline/AppData/Local/Mendeley Ltd./Mendeley Desktop/Downloaded/Peris et al. - 2018 - A key function for microtubule-associated-protein 6 in activity-dependent stabilisation of actin filaments in dend.pdf:pdf}, interhash = {079c52edc9ab563db11b7ba2a7897e29}, intrahash = {f5470f4453b9f9df64061acdc58703a3}, issn = {20411723}, journal = {Nature Communications}, keywords = {actin dendrite microtubules neuro plasticity}, month = dec, number = 1, pages = {1--15}, publisher = {Nature Publishing Group}, timestamp = {2020-03-23T23:00:26.000+0100}, title = {{A key function for microtubule-associated-protein 6 in activity-dependent stabilisation of actin filaments in dendritic spines}}, volume = 9, year = 2018 }