Abstract
From April 1996 to July 2004, an outbreak of metallo-beta-lactamase-positive (MBL) Pseudomonas aeruginosa occurred in the haematology ward at Nantes University Hospital in France. Fifty-nine patients were carriers of VIM-2-positive strains of whom 14 were infected (mostly urinary tract infections and pneumonia). Pulsed-field gel electrophoresis identified related isolates demonstrating resistance to all beta-lactams, aminoglycosides, fluoroquinolones, fosfomycin, rifampicin but not colistin. The bla(VIM-2) gene responsible for VIM-2 MBL was not plasmid-encoded but part of a novel type of class 1 integron. VIM-2-positive strains were mostly from urine samples and clinical data suggest that in the absence of therapeutic guidelines, piperacillin-tazobactam or aztreonam may be a reliable choice for treating infections with MBL-producing strains.
- 80
- adult,
- aeruginosa,
- aged,
- and
- bacterial,
- base
- cross
- data,
- disease
- drug
- electrophoresis,
- female,
- france,
- gel,
- hospitals,
- humans,
- infection,
- infections
- integrons,
- male,
- middle
- molecular
- multiple,
- outbreaks,
- over,
- phylogeny,
- pseudomonas
- resistance,
- sequence
- sequence,
- university,
- {beta-lactamases,}
- {pulsed-field,}
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