%0 Journal Article %1 Adair1992 %A Adair, J. %A Filloux, F. %D 1992 %J J Child Neurol %K Animals; Animals, Newborn; Asphyxia Neonatorum; Autoradiography; Brain; Brain Damage, Chronic; Cerebral Palsy; Dopamine; Humans; Hypoxia, Infant, Rats; Rats, Inbred Strains; Receptors, Dopamine D1; D2 %N 2 %P 199--207 %T Effects of hypoxic-ischemic brain damage on dopaminergic markers in the neonatal rat: a regional autoradiographic analysis. %V 7 %X Dopamine has been implicated as an endogenous substance that may mediate neuronal death after hypoxic-ischemic insult. Using semiquantitative autoradiography, we studied the effect of perinatal hypoxic-ischemic injury on dopamine binding sites in rat brain. Experimental injury resulted in a substantial decrease in dopamine type-1 (D1) and forskolin (adenylate cyclase) binding sites. In contrast, markers for dopamine type-2 (D2) sites and for dopamine uptake were unaffected in lesioned animals. Changes within dopaminergic pathways were variable, with reduction in binding being encountered mainly in components of the extrapyramidal motor system: caudate-putamen, -61\%; globus pallidus, -64\%; entopeduncular nucleus, -60\%; and substantia nigra, -69\%. Furthermore, the topography of D1 receptor loss within the caudate-putamen was not uniform, with the greatest decrement in dorsolateral regions. Reduced D1 versus D2 receptor activation may underlie extrapyramidal movement disorders that appear as a consequence of perinatal hypoxic-ischemic insult.

@article{Adair1992, abstract = {Dopamine has been implicated as an endogenous substance that may mediate neuronal death after hypoxic-ischemic insult. Using semiquantitative autoradiography, we studied the effect of perinatal hypoxic-ischemic injury on dopamine binding sites in rat brain. Experimental injury resulted in a substantial decrease in dopamine type-1 (D1) and forskolin (adenylate cyclase) binding sites. In contrast, markers for dopamine type-2 (D2) sites and for dopamine uptake were unaffected in lesioned animals. Changes within dopaminergic pathways were variable, with reduction in binding being encountered mainly in components of the extrapyramidal motor system: caudate-putamen, -61\%; globus pallidus, -64\%; entopeduncular nucleus, -60\%; and substantia nigra, -69\%. Furthermore, the topography of D1 receptor loss within the caudate-putamen was not uniform, with the greatest decrement in dorsolateral regions. Reduced D1 versus D2 receptor activation may underlie extrapyramidal movement disorders that appear as a consequence of perinatal hypoxic-ischemic insult.}, added-at = {2014-07-19T17:35:56.000+0200}, author = {Adair, J. and Filloux, F.}, biburl = {https://www.bibsonomy.org/bibtex/2911a79fc247bf6d739a7ade7cf30420f/ar0berts}, groups = {public}, interhash = {940d58254460a79b81015f51f6481adb}, intrahash = {911a79fc247bf6d739a7ade7cf30420f}, journal = {J Child Neurol}, keywords = {Animals; Animals, Newborn; Asphyxia Neonatorum; Autoradiography; Brain; Brain Damage, Chronic; Cerebral Palsy; Dopamine; Humans; Hypoxia, Infant, Rats; Rats, Inbred Strains; Receptors, Dopamine D1; D2}, month = Apr, number = 2, pages = {199--207}, pmid = {1533408}, timestamp = {2014-07-19T17:35:56.000+0200}, title = {Effects of hypoxic-ischemic brain damage on dopaminergic markers in the neonatal rat: a regional autoradiographic analysis.}, username = {ar0berts}, volume = 7, year = 1992 }