%0 Journal Article %1 Hume_1991_C399 %A Hume, J. R. %A Harvey, R. D. %D 1991 %J Am. J. Physiol. %K 1716049 AMP, Animals, Channels, Chloride Chlorides, Cyclic Electrophysiology, Female, Gov't, Heart, Ion Membrane Non-U.S. P.H.S., Potentials, Pregnancy, Proteins, Research Support, U.S. %N 3 Pt 1 %P C399--C412 %T Chloride conductance pathways in heart. %U http://ajpcell.physiology.org/cgi/content/abstract/261/3/C399 %V 261 %X Nonelectrogenic movement of Cl$^-$ is believed to be responsible for the active accumulation of intracellular Cl$^-$ in cardiac muscle. The electro-neutral pathways underlying this nonpassive distribution of Cl$^-$ are believed to include Cl$^-$-HCO3- exchange, Na$^+$-dependent cotransport (operating as Na$^+$-Cl$^-$ and Na$^+$-K$^+$-2Cl$^-$ cotransport), and K$^+$-Cl$^-$ cotransport. The electrogenic movement of Cl$^-$ in cardiac muscle is particularly interesting from a historical perspective. Until recently, there was some doubt as to whether Cl$^-$ carried any current in the heart. Early microelectrode experiments indicated that a Cl$^-$ conductance probably played an important role in regulating action potential duration and resting membrane potential. Subsequent voltage-clamp experiments identified a repolarizing, transient outward current that was believed to be conducted by Cl$^-$, yet further investigation suggested that this transient outward current was more likely a K$^+$ current, not a Cl$^-$ current. This left some doubt as to whether Cl$^-$ played any role in regulating membrane potential in cardiac muscle. More recent studies, however, have identified a highly selective Cl$^-$ conductance that is regulated by intracellular adenosine 3',5'-cyclic monophosphate, and it appears that this Cl$^-$ current may play an important role in the regulation of action potential duration and resting membrane potential.

@article{Hume_1991_C399, abstract = {Nonelectrogenic movement of {C}l$^{-}$ is believed to be responsible for the active accumulation of intracellular {C}l$^{-}$ in cardiac muscle. The electro-neutral pathways underlying this nonpassive distribution of {C}l$^{-}$ are believed to include {C}l$^{-}$-{HCO}3- exchange, {N}a$^{+}$-dependent cotransport (operating as {N}a$^{+}$-{C}l$^{-}$ and {N}a$^{+}$-{K}$^{+}$-2{C}l$^{-}$ cotransport), and {K}$^{+}$-{C}l$^{-}$ cotransport. The electrogenic movement of {C}l$^{-}$ in cardiac muscle is particularly interesting from a historical perspective. Until recently, there was some doubt as to whether {C}l$^{-}$ carried any current in the heart. Early microelectrode experiments indicated that a {C}l$^{-}$ conductance probably played an important role in regulating action potential duration and resting membrane potential. Subsequent voltage-clamp experiments identified a repolarizing, transient outward current that was believed to be conducted by {C}l$^{-}$, yet further investigation suggested that this transient outward current was more likely a {K}$^{+}$ current, not a {C}l$^{-}$ current. This left some doubt as to whether {C}l$^{-}$ played any role in regulating membrane potential in cardiac muscle. More recent studies, however, have identified a highly selective {C}l$^{-}$ conductance that is regulated by intracellular adenosine 3',5'-cyclic monophosphate, and it appears that this {C}l$^{-}$ current may play an important role in the regulation of action potential duration and resting membrane potential.}, added-at = {2009-06-03T11:20:58.000+0200}, author = {Hume, J. R. and Harvey, R. D.}, biburl = {https://www.bibsonomy.org/bibtex/29759f52a74ec98d997185b0437f17bdf/hake}, description = {The whole bibliography file I use.}, file = {Hume_1991_C399.pdf:Hume_1991_C399.pdf:PDF}, interhash = {a459baf3b26c347632654366cb84952b}, intrahash = {9759f52a74ec98d997185b0437f17bdf}, journal = {Am. J. Physiol.}, keywords = {1716049 AMP, Animals, Channels, Chloride Chlorides, Cyclic Electrophysiology, Female, Gov't, Heart, Ion Membrane Non-U.S. P.H.S., Potentials, Pregnancy, Proteins, Research Support, U.S.}, month = Sep, number = {3 Pt 1}, pages = {C399--C412}, pmid = {1716049}, timestamp = {2009-06-03T11:21:15.000+0200}, title = {Chloride conductance pathways in heart.}, url = {http://ajpcell.physiology.org/cgi/content/abstract/261/3/C399}, volume = 261, year = 1991 }