%0 Journal Article %1 WOS:000583325200012 %A Rodrigues, Jessica Andreza Oliveira %A de Oliveira Neto, Joao Gomes %A da Silva de Barros, Aline Oliveira %A Ayala, Alejandro Pedro %A Santos-Oliveira, Ralph %A de Menezes, Alan Silva %A de Sousa, Francisco Ferreira %C THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND %D 2020 %I PERGAMON-ELSEVIER SCIENCE LTD %J POLYHEDRON %K Breast Copper Melanoma; Phenanthroline; acids; cancer} complex; {Amino %R 10.1016/j.poly.2020.114807 %T Copper(II):phenanthroline complexes with L-asparagine and L-methionine: Synthesis, crystal structure and in-vitro cytotoxic effects on prostate, breast and melanoma cancer cells %V 191 %X Here we report the cytotoxic effects of the two ternary copper(II) complexes Cu(Phen)(L-methionine) H2OCl center dot 1.5H(2)O (Cu(PHEN)(MET)) and Cu(Phen)(L-asparagine)H2OClH2O (Cu(PHEN)(ASN)), which showed high chemotherapy potential against cancer cells lines. A novel ternary copper(II) complex, Cu (PHEN)(ASN) has been synthesized and its crystalline structure has been determined by single crystal X-ray diffraction. The new complex crystallized in a triclinic system with P-1 space group. The copper (II) center is situated in a trigonal bipyramidal molecular geometry. Both complexes exhibited potent cytotoxic effects against cancer cells lines, killing 100% human melanoma cancer cells line MV3 and 90% human breast cancer cells line MCF7 at a concentration of 50 mu g/ml. Less pronounced but still very good effects were observed for human breast cancer cells line MDA-MB-23 and human prostate cancer cells lines DU-145 and PC3, where both complexes killed about 70% of these cells lines at a concentration of 50 mu g/ml. The Cu(PHEN)(MET) and Cu(PHEN)(ASN) complexes also presented low IC50 values. (C) 2020 Elsevier Ltd. All rights reserved.

@article{WOS:000583325200012, abstract = {Here we report the cytotoxic effects of the two ternary copper(II) complexes [Cu(Phen)(L-methionine) H2O]Cl center dot 1.5H(2)O (Cu(PHEN)(MET)) and [Cu(Phen)(L-asparagine)H2OCl]H2O (Cu(PHEN)(ASN)), which showed high chemotherapy potential against cancer cells lines. A novel ternary copper(II) complex, Cu (PHEN)(ASN) has been synthesized and its crystalline structure has been determined by single crystal X-ray diffraction. The new complex crystallized in a triclinic system with P-1 space group. The copper (II) center is situated in a trigonal bipyramidal molecular geometry. Both complexes exhibited potent cytotoxic effects against cancer cells lines, killing 100% human melanoma cancer cells line MV3 and 90% human breast cancer cells line MCF7 at a concentration of 50 mu g/ml. Less pronounced but still very good effects were observed for human breast cancer cells line MDA-MB-23 and human prostate cancer cells lines DU-145 and PC3, where both complexes killed about 70% of these cells lines at a concentration of 50 mu g/ml. The Cu(PHEN)(MET) and Cu(PHEN)(ASN) complexes also presented low IC50 values. (C) 2020 Elsevier Ltd. All rights reserved.}, added-at = {2022-05-23T20:00:14.000+0200}, address = {THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND}, author = {Rodrigues, Jessica Andreza Oliveira and de Oliveira Neto, Joao Gomes and da Silva de Barros, Aline Oliveira and Ayala, Alejandro Pedro and Santos-Oliveira, Ralph and de Menezes, Alan Silva and de Sousa, Francisco Ferreira}, biburl = {https://www.bibsonomy.org/bibtex/2c53f29c0a51f50475b05e9486b7985b8/ppgfis_ufc_br}, doi = {10.1016/j.poly.2020.114807}, interhash = {c654905e95c9d7f7bb66d3658bfad1d7}, intrahash = {c53f29c0a51f50475b05e9486b7985b8}, issn = {0277-5387}, journal = {POLYHEDRON}, keywords = {Breast Copper Melanoma; Phenanthroline; acids; cancer} complex; {Amino}, publisher = {PERGAMON-ELSEVIER SCIENCE LTD}, pubstate = {published}, timestamp = {2022-05-23T20:00:14.000+0200}, title = {Copper(II):phenanthroline complexes with L-asparagine and L-methionine: Synthesis, crystal structure and in-vitro cytotoxic effects on prostate, breast and melanoma cancer cells}, tppubtype = {article}, volume = 191, year = 2020 }