%0 Journal Article %1 kroon2 %A Kroon, M. %C 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND %D 2011 %I TAYLOR & FRANCIS LTD %J COMPUTER METHODS IN BIOMECHANICS AND BIOMEDICAL ENGINEERING %K constitutive muscle %N 1 %P 43-52 %R 10.1080/10255842.2010.493521 %T Optimal length of smooth muscle assessed by a microstructurally and statistically based constitutive model %V 14 %X Smooth muscle exhibits an optimal length at which it is able to generate a maximum amount of force. In this study, the optimal length is assessed by use of a microstructurally and statistically based constitutive model for smooth muscle. The model is based on the sliding filament theory, and a modified version of Hill's mechanical model was adopted. It was conjectured, that a variation in the overlap in the actomyosin contractile units together with a statistical dispersion in the size of the dense bodies are responsible for the optimal length characteristics. The influence of contractile unit length, dense body size and dense body compliance was investigated, and the model was fully able to predict experimental data. The results indicate that the compliance of the dense bodies does not contribute significantly to the total compliance of the contractile apparatus.

@article{kroon2, abstract = {{Smooth muscle exhibits an optimal length at which it is able to generate a maximum amount of force. In this study, the optimal length is assessed by use of a microstructurally and statistically based constitutive model for smooth muscle. The model is based on the sliding filament theory, and a modified version of Hill's mechanical model was adopted. It was conjectured, that a variation in the overlap in the actomyosin contractile units together with a statistical dispersion in the size of the dense bodies are responsible for the optimal length characteristics. The influence of contractile unit length, dense body size and dense body compliance was investigated, and the model was fully able to predict experimental data. The results indicate that the compliance of the dense bodies does not contribute significantly to the total compliance of the contractile apparatus.}}, added-at = {2013-01-07T13:53:20.000+0100}, address = {{4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND}}, affiliation = {{Kroon, M (Reprint Author), Royal Inst Technol, Dept Solid Mech, S-10044 Stockholm, SE, Sweden.. Kroon, M., Royal Inst Technol, Dept Solid Mech, S-10044 Stockholm, SE, Sweden.}}, author = {Kroon, M.}, author-email = {{martin@hallf.kth.se}}, biburl = {https://www.bibsonomy.org/bibtex/26d5114639063801b7998d4e3b3fcdb54/jehiorns}, doc-delivery-number = {{723VY}}, doi = {{10.1080/10255842.2010.493521}}, interhash = {cdec6f490938536410eb5ad646a12e61}, intrahash = {6d5114639063801b7998d4e3b3fcdb54}, issn = {{1025-5842}}, journal = {{COMPUTER METHODS IN BIOMECHANICS AND BIOMEDICAL ENGINEERING}}, journal-iso = {{Comput. Methods Biomech. Biomed. Eng.}}, keywords = {constitutive muscle}, keywords-plus = {{LATCH-BRIDGE MODEL; MYOSIN-FILAMENTS; ULTRASTRUCTURAL BASIS; CONTRACTION; FORCE; PHOSPHORYLATION; ACTIN; TONE; EXTENSIBILITY; ADAPTATION}}, language = {{English}}, number = {{1}}, number-of-cited-references = {{43}}, pages = {{43-52}}, publisher = {{TAYLOR \& FRANCIS LTD}}, research-areas = {{Computer Science; Engineering}}, times-cited = {{0}}, timestamp = {2013-01-07T13:53:20.000+0100}, title = {{Optimal length of smooth muscle assessed by a microstructurally and statistically based constitutive model}}, type = {{Article}}, unique-id = {{ISI:000287536600005}}, volume = {{14}}, web-of-science-categories = {{Computer Science, Interdisciplinary Applications; Engineering, Biomedical}}, year = {{2011}} }