%0 Journal Article %1 WarnekeWittstock.1998 %A Warneke-Wittstock, R. %A Marquardt, A. %A Gehrig, A. %A Sauer, C. G. %A Gessler, M. %A Weber, B. H. %D 1998 %J Genomics %K *Chromosome Aberrations/genetics Acid Amino Chromosome Chromosome/*genetics Chromosomes;Human/*genetics Data Exons Expression Gene Homology;Amino Humans Mapping Molecular RNA;Messenger/*genetics Sequence Sex Transcription;Genetic X %N 1 %P 59--67 %T Transcript map of a 900-kb genomic region in Xp22.1-p22.2: identification of 12 novel genes %V 51 %X The Xp22.1-p22.2 interval is a focus of interest as a number of hereditary disease loci have been mapped to this region, including X-linked nonsyndromic sensorineural deafness (DFN6), X-linked juvenile retinoschisis (RS), and several X-linked mental retardation syndromes. In the course of cloning the RS gene we have assembled YAC and PAC contigs of the 900-kb candidate region delimited by DXS418 and DXS999. In this study, we now report the construction of a first transcript map of this chromosomal interval by combining exon trapping, EST mapping, and computational gene identification methods. Overall, this strategy has led to the assembly of at least 12 novel transcripts positioned within the DXS418-DXS999 region, one of these encoding a putative protein kinase motif with significant homology to the rat p58/GTA protein kinase domain and another a putative neuronal protein with strong homology to a Drosophila transcriptional repressor.

@article{WarnekeWittstock.1998, abstract = {The Xp22.1-p22.2 interval is a focus of interest as a number of hereditary disease loci have been mapped to this region, including X-linked nonsyndromic sensorineural deafness (DFN6), X-linked juvenile retinoschisis (RS), and several X-linked mental retardation syndromes. In the course of cloning the RS gene we have assembled YAC and PAC contigs of the 900-kb candidate region delimited by DXS418 and DXS999. In this study, we now report the construction of a first transcript map of this chromosomal interval by combining exon trapping, EST mapping, and computational gene identification methods. Overall, this strategy has led to the assembly of at least 12 novel transcripts positioned within the DXS418-DXS999 region, one of these encoding a putative protein kinase motif with significant homology to the rat p58/GTA protein kinase domain and another a putative neuronal protein with strong homology to a Drosophila transcriptional repressor.}, added-at = {2013-01-29T13:47:26.000+0100}, author = {Warneke-Wittstock, R. and Marquardt, A. and Gehrig, A. and Sauer, C. G. and Gessler, M. and Weber, B. H.}, biburl = {https://www.bibsonomy.org/bibtex/2fc3f9b5cf8a9de9846b93d89ec9c3c3a/ebch}, interhash = {d3dd2271d50d884dedd3967dc81c20ed}, intrahash = {fc3f9b5cf8a9de9846b93d89ec9c3c3a}, journal = {Genomics}, keywords = {*Chromosome Aberrations/genetics Acid Amino Chromosome Chromosome/*genetics Chromosomes;Human/*genetics Data Exons Expression Gene Homology;Amino Humans Mapping Molecular RNA;Messenger/*genetics Sequence Sex Transcription;Genetic X}, number = 1, pages = {59--67}, timestamp = {2013-01-29T13:47:35.000+0100}, title = {Transcript map of a 900-kb genomic region in Xp22.1-p22.2: identification of 12 novel genes}, volume = 51, year = 1998 }