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The Association Between Vitamin D Level with IgA Plasma Level in Pregnant COVID-19 Patients

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CENTRAL ASIAN JOURNAL OF MEDICAL AND NATURAL SCIENCE, 4 (6): 217-224 (декабря 2023)

Аннотация

Background: Coronavirus disease (COVID-19) has emerged as a harmful pandemic this century, brought on by severe acute respiratory illness coronavirus-2. An ecological study has shown that greater levels of vitamin D intake are inversely linked with the occurrence and/or death of COVID-19 in communities with a genetic predisposition towards low micronutrient levels. IgA, the predominant immunoglobulin of the respiratory system, is the main entry point for a variety of bacteria.. Aim: The IgA plasma levels of COVID-19 pregnant patients were examined to see if there was a relationship with their vitamin D levels.. Patients and methods: At Bint -Alhuda teaching hospital, Obstetrics and Gynecology department and a private obstetrical clinic carried out a case control study from January to December 2022 to compare the levels of vitamin D and IgA in pregnant women with COVID-19 to those who did not have the virus. The study's objective was accomplished using a sample of 179 patients split into two groups. Group B comprised 77 healthy pregnant women who served as the control group, while Group A comprised 102 pregnant women who had COVID-19 at any point throughout their pregnancy... Results: The mean of trimester, parity, family history of COVID-19, presence of COVID-19, and immunization history were found to differ significantly (p<0.05) in this study. When compared to the control group, pregnant women with a COVID-19 infection were shown to have significantly reduced levels of vitamin D and IgA (P=0.0001). It's interesting to note that, independent of group, a small but statistically significant positive association was found between both Vit D levels and IgA levels. Further investigation revealed a correlation between an IgA level above >2.1 and a case's sensitivity of 72%, specificity of 63%, and accuracy of 68%..

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