%0 Journal Article %1 Jones2006sEHSAR %A Jones, Paul D. %A Tsai, Hsing-Ju %A Do, Zung N. %A Morisseau, Christophe %A Hammock, Bruce D. %D 2006 %J Bioorganic & Medicinal Chemistry Letters %K drug-discovery drugs inhibitors sEH seh-ligands %N 19 %P 5212 - 5216 %R https://doi.org/10.1016/j.bmcl.2006.07.009 %T Synthesis and \SAR\ of conformationally restricted inhibitors of soluble epoxide hydrolase %U http://www.sciencedirect.com/science/article/pii/S0960894X06007815 %V 16 %X A series of conformationally restricted inhibitors of human soluble epoxide hydrolase (sEH) has been developed. Inhibition potency of the described compounds ranges from 4.2 μM to 1.1 nM against recombinant sEH. N-(1-Acetylpiperidin-4-yl)-N′-(adamant-1-yl) urea (5a) was found to be a potent inhibitor (IC50 = 7.0 nM) that was also orally bioavailable in canines.

@article{Jones2006sEHSAR, abstract = {A series of conformationally restricted inhibitors of human soluble epoxide hydrolase (sEH) has been developed. Inhibition potency of the described compounds ranges from 4.2 μM to 1.1 nM against recombinant sEH. N-(1-Acetylpiperidin-4-yl)-N′-(adamant-1-yl) urea (5a) was found to be a potent inhibitor (IC50 = 7.0 nM) that was also orally bioavailable in canines. }, added-at = {2017-06-22T18:40:54.000+0200}, author = {Jones, Paul D. and Tsai, Hsing-Ju and Do, Zung N. and Morisseau, Christophe and Hammock, Bruce D.}, biburl = {https://www.bibsonomy.org/bibtex/20b1febf4444afba1e4c40d2f264511ed/salotz}, doi = {https://doi.org/10.1016/j.bmcl.2006.07.009}, interhash = {058ecf81bdd26b6e20cee3ba3bc91203}, intrahash = {0b1febf4444afba1e4c40d2f264511ed}, issn = {0960-894X}, journal = {Bioorganic & Medicinal Chemistry Letters }, keywords = {drug-discovery drugs inhibitors sEH seh-ligands}, number = 19, pages = {5212 - 5216}, timestamp = {2017-06-22T18:40:54.000+0200}, title = {Synthesis and \{SAR\} of conformationally restricted inhibitors of soluble epoxide hydrolase }, url = {http://www.sciencedirect.com/science/article/pii/S0960894X06007815}, volume = 16, year = 2006 }