%0 Journal Article %1 pmid8819174 %A Bork, P. %A Brown, N. P. %A Hegyi, H. %A Schultz, J. %D 1996 %J Protein Sci. %K imported %P 1421--1425 %T The protein phosphatase 2C (PP2C) superfamily: detection of bacterial homologues %V 5 %X A thorough sequence analysis of the various members of the eukaryotic protein serine/threonine phosphatase 2C (PP2C) family revealed the conservation of 11 motifs. These motifs could be identified in numerous other sequences, including fungal adenylate cyclases that are predicted to contain a functionally active PP2C domain, and a family of prokaryotic serine/threonine phosphatases including SpoIIE. Phylogenetic analysis of all the proteins indicates a widespread sequence family for which a considerable number of isoenzymes can be inferred.

@article{pmid8819174, abstract = {A thorough sequence analysis of the various members of the eukaryotic protein serine/threonine phosphatase 2C (PP2C) family revealed the conservation of 11 motifs. These motifs could be identified in numerous other sequences, including fungal adenylate cyclases that are predicted to contain a functionally active PP2C domain, and a family of prokaryotic serine/threonine phosphatases including SpoIIE. Phylogenetic analysis of all the proteins indicates a widespread sequence family for which a considerable number of isoenzymes can be inferred.}, added-at = {2011-07-21T16:10:59.000+0200}, author = {Bork, P. and Brown, N. P. and Hegyi, H. and Schultz, J.}, biburl = {https://www.bibsonomy.org/bibtex/23ed5b997cce7a83be4d94ff6f2963005/jschultz}, interhash = {25f67686fff0c72fe9e94dcb4406ce67}, intrahash = {3ed5b997cce7a83be4d94ff6f2963005}, journal = {Protein Sci.}, keywords = {imported}, month = Jul, pages = {1421--1425}, timestamp = {2011-07-21T16:11:01.000+0200}, title = {{{T}he protein phosphatase 2{C} ({P}{P}2{C}) superfamily: detection of bacterial homologues}}, volume = 5, year = 1996 }