%0 Journal Article %1 Buescher2012Global %A Buescher, Joerg M. %A Liebermeister, Wolfram %A Jules, Matthieu %A Uhr, Markus %A Muntel, Jan %A Botella, Eric %A Hessling, Bernd %A Kleijn, Roelco J. %A Le Chat, Ludovic %A Lecointe, Francois %A Mäder, Ulrike %A Nicolas, Pierre %A Piersma, Sjouke %A Rügheimer, Frank %A Becher, Dörte %A Bessieres, Philippe %A Bidnenko, Elena %A Denham, Emma L. %A Dervyn, Etienne %A Devine, Kevin M. %A Doherty, Geoff %A Drulhe, Samuel %A Felicori, Liza %A Fogg, Mark J. %A Goelzer, Anne %A Hansen, Annette %A Harwood, Colin R. %A Hecker, Michael %A Hubner, Sebastian %A Hultschig, Claus %A Jarmer, Hanne %A Klipp, Edda %A Leduc, Aurélie %A Lewis, Peter %A Molina, Frank %A Noirot, Philippe %A Peres, Sabine %A Pigeonneau, Nathalie %A Pohl, Susanne %A Rasmussen, Simon %A Rinn, Bernd %A Schaffer, Marc %A Schnidder, Julian %A Schwikowski, Benno %A Van Dijl, Jan M. %A Veiga, Patrick %A Walsh, Sean %A Wilkinson, Anthony J. %A Stelling, Jörg %A Aymerich, Stéphane %A Sauer, Uwe %D 2012 %I American Association for the Advancement of Science %J Science %K adaptation bt3240 metabolic-networks regulation %N 6072 %P 1099--1103 %R 10.1126/science.1206871 %T Global Network Reorganization During Dynamic Adaptations of Bacillus subtilis Metabolism %U http://dx.doi.org/10.1126/science.1206871 %V 335 %X Adaptation of cells to environmental changes requires dynamic interactions between metabolic and regulatory networks, but studies typically address only one or a few layers of regulation. For nutritional shifts between two preferred carbon sources of Bacillus subtilis, we combined statistical and model-based data analyses of dynamic transcript, protein, and metabolite abundances and promoter activities. Adaptation to malate was rapid and primarily controlled posttranscriptionally compared with the slow, mainly transcriptionally controlled adaptation to glucose that entailed nearly half of the known transcription regulation network. Interactions across multiple levels of regulation were involved in adaptive changes that could also be achieved by controlling single genes. Our analysis suggests that global trade-offs and evolutionary constraints provide incentives to favor complex control programs.

@article{Buescher2012Global, abstract = { Adaptation of cells to environmental changes requires dynamic interactions between metabolic and regulatory networks, but studies typically address only one or a few layers of regulation. For nutritional shifts between two preferred carbon sources of Bacillus subtilis, we combined statistical and model-based data analyses of dynamic transcript, protein, and metabolite abundances and promoter activities. Adaptation to malate was rapid and primarily controlled posttranscriptionally compared with the slow, mainly transcriptionally controlled adaptation to glucose that entailed nearly half of the known transcription regulation network. Interactions across multiple levels of regulation were involved in adaptive changes that could also be achieved by controlling single genes. Our analysis suggests that global trade-offs and evolutionary constraints provide incentives to favor complex control programs. }, added-at = {2018-12-02T16:09:07.000+0100}, author = {Buescher, Joerg M. and Liebermeister, Wolfram and Jules, Matthieu and Uhr, Markus and Muntel, Jan and Botella, Eric and Hessling, Bernd and Kleijn, Roelco J. and Le Chat, Ludovic and Lecointe, Fran\c{c}ois and M\"{a}der, Ulrike and Nicolas, Pierre and Piersma, Sjouke and R\"{u}gheimer, Frank and Becher, D\"{o}rte and Bessieres, Philippe and Bidnenko, Elena and Denham, Emma L. and Dervyn, Etienne and Devine, Kevin M. and Doherty, Geoff and Drulhe, Samuel and Felicori, Liza and Fogg, Mark J. and Goelzer, Anne and Hansen, Annette and Harwood, Colin R. and Hecker, Michael and Hubner, Sebastian and Hultschig, Claus and Jarmer, Hanne and Klipp, Edda and Leduc, Aur\'{e}lie and Lewis, Peter and Molina, Frank and Noirot, Philippe and Peres, Sabine and Pigeonneau, Nathalie and Pohl, Susanne and Rasmussen, Simon and Rinn, Bernd and Schaffer, Marc and Schnidder, Julian and Schwikowski, Benno and Van Dijl, Jan M. and Veiga, Patrick and Walsh, Sean and Wilkinson, Anthony J. and Stelling, J\"{o}rg and Aymerich, St\'{e}phane and Sauer, Uwe}, biburl = {https://www.bibsonomy.org/bibtex/2e0e4eec5eeff7516fec4f07811be036e/karthikraman}, citeulike-article-id = {10407975}, citeulike-linkout-0 = {http://dx.doi.org/10.1126/science.1206871}, citeulike-linkout-1 = {http://www.sciencemag.org/content/335/6072/1099.abstract}, citeulike-linkout-2 = {http://www.sciencemag.org/content/335/6072/1099.full.pdf}, citeulike-linkout-3 = {http://www.sciencemag.org/cgi/content/abstract/335/6072/1099}, citeulike-linkout-4 = {http://view.ncbi.nlm.nih.gov/pubmed/22383848}, citeulike-linkout-5 = {http://www.hubmed.org/display.cgi?uids=22383848}, day = 02, doi = {10.1126/science.1206871}, interhash = {3d8b190a92efa9188f3e33f011b25c0d}, intrahash = {e0e4eec5eeff7516fec4f07811be036e}, issn = {1095-9203}, journal = {Science}, keywords = {adaptation bt3240 metabolic-networks regulation}, month = mar, number = 6072, pages = {1099--1103}, pmid = {22383848}, posted-at = {2012-03-13 04:08:38}, priority = {2}, publisher = {American Association for the Advancement of Science}, timestamp = {2018-12-02T16:09:07.000+0100}, title = {Global Network Reorganization During Dynamic Adaptations of Bacillus subtilis Metabolism}, url = {http://dx.doi.org/10.1126/science.1206871}, volume = 335, year = 2012 }