%0 Journal Article %1 10.1371/journal.pbio.2006506 %A Ferreirós-Vidal, Isabel %A Carroll, Thomas %A Zhang, Tianyi %A Lagani, Vincenzo %A Ramirez, Ricardo N. %A Ing-Simmons, Elizabeth %A Garcia, Alicia %A Cooper, Lee %A Liang, Ziwei %A Papoutsoglou, Georgios %A Dharmalingam, Gopuraja %A Guo, Ya %A Tarazona, Sonia %A Fernandes, Sunjay J. %A Noori, Peri %A Silberberg, Gilad %A Fisher, Amanda G. %A Tsamardinos, Ioannis %A Mortazavi, Ali %A Lenhard, Boris %A Conesa, Ana %A Tegner, Jesper %A Merkenschlager, Matthias %A Gomez-Cabrero, David %D 2019 %I Public Library of Science %J PLOS Biology %K mxmcausalpath %N 4 %P 1-28 %R 10.1371/journal.pbio.2006506 %T Feedforward regulation of Myc coordinates lineage-specific with housekeeping gene expression during B cell progenitor cell differentiation %U https://doi.org/10.1371/journal.pbio.2006506 %V 17 %X The human body is made from billions of cells comprizing many specialized cell types. All of these cells ultimately come from a single fertilized oocyte in a process that has two key features: proliferation, which expands cell numbers, and differentiation, which diversifies cell types. Here, we have examined the transition from proliferation to differentiation using B lymphocytes as an example. We find that the transition from proliferation to differentiation involves changes in the expression of genes, which can be categorized into cell-type–specific genes and broadly expressed “housekeeping” genes. The expression of many housekeeping genes is controlled by the gene regulatory factor Myc, whereas the expression of many B lymphocyte–specific genes is controlled by the Ikaros family of gene regulatory proteins. Myc is repressed by Ikaros, which means that changes in housekeeping and tissue-specific gene expression are coordinated during the transition from proliferation to differentiation.

@article{10.1371/journal.pbio.2006506, abstract = {The human body is made from billions of cells comprizing many specialized cell types. All of these cells ultimately come from a single fertilized oocyte in a process that has two key features: proliferation, which expands cell numbers, and differentiation, which diversifies cell types. Here, we have examined the transition from proliferation to differentiation using B lymphocytes as an example. We find that the transition from proliferation to differentiation involves changes in the expression of genes, which can be categorized into cell-type–specific genes and broadly expressed “housekeeping” genes. The expression of many housekeeping genes is controlled by the gene regulatory factor Myc, whereas the expression of many B lymphocyte–specific genes is controlled by the Ikaros family of gene regulatory proteins. Myc is repressed by Ikaros, which means that changes in housekeeping and tissue-specific gene expression are coordinated during the transition from proliferation to differentiation.}, added-at = {2019-04-15T10:34:19.000+0200}, author = {Ferreirós-Vidal, Isabel and Carroll, Thomas and Zhang, Tianyi and Lagani, Vincenzo and Ramirez, Ricardo N. and Ing-Simmons, Elizabeth and Garcia, Alicia and Cooper, Lee and Liang, Ziwei and Papoutsoglou, Georgios and Dharmalingam, Gopuraja and Guo, Ya and Tarazona, Sonia and Fernandes, Sunjay J. and Noori, Peri and Silberberg, Gilad and Fisher, Amanda G. and Tsamardinos, Ioannis and Mortazavi, Ali and Lenhard, Boris and Conesa, Ana and Tegner, Jesper and Merkenschlager, Matthias and Gomez-Cabrero, David}, biburl = {https://www.bibsonomy.org/bibtex/2bd3e0f1a5421ea097c5f5c72221afddf/mensxmachina}, doi = {10.1371/journal.pbio.2006506}, interhash = {47806e111971adfc2e5769052393b71e}, intrahash = {bd3e0f1a5421ea097c5f5c72221afddf}, journal = {PLOS Biology}, keywords = {mxmcausalpath}, month = {04}, number = 4, pages = {1-28}, publisher = {Public Library of Science}, timestamp = {2021-03-10T09:19:14.000+0100}, title = {Feedforward regulation of Myc coordinates lineage-specific with housekeeping gene expression during B cell progenitor cell differentiation}, url = {https://doi.org/10.1371/journal.pbio.2006506}, volume = 17, year = 2019 }