%0 Generic %1 Fu2009 %A Fu, Yan %A Zhu, Meng %A Xing, Jianhua %D 2009 %K arxiv bacterial_colony %T Resonant activation: a strategy against bacterial persistence %U http://arxiv.org/abs/0909.5125 %X A bacteria colony may develop a small number of cells genetically identical,but phenotypically different from the majority cells in the populations. Theseso-called persister cells are insensitive to antibiotics treatment, andcontribute to the serious problem of drug resistance. Resonant activation (RA)is a well-studied phenomenon in thermally activated barrier crossing events,where internal noise can constructively facilitate the barrier crossing.Through stochastic Gilliespie simulation with a generic toggle switch model, wedemonstrated that the phenomenon also exist for cell phenotype switching. Thenwe used coupled single cell and population simulations to demonstrate that onecan greatly reduce the time and the total amount of antibiotics needed toextinct a bacteria population with RA. We also suggested that RA can findapplication in other situations such as cancer radiotherapy.

@misc{Fu2009, abstract = { A bacteria colony may develop a small number of cells genetically identical,but phenotypically different from the majority cells in the populations. Theseso-called persister cells are insensitive to antibiotics treatment, andcontribute to the serious problem of drug resistance. Resonant activation (RA)is a well-studied phenomenon in thermally activated barrier crossing events,where internal noise can constructively facilitate the barrier crossing.Through stochastic Gilliespie simulation with a generic toggle switch model, wedemonstrated that the phenomenon also exist for cell phenotype switching. Thenwe used coupled single cell and population simulations to demonstrate that onecan greatly reduce the time and the total amount of antibiotics needed toextinct a bacteria population with RA. We also suggested that RA can findapplication in other situations such as cancer radiotherapy.}, added-at = {2009-10-21T04:26:39.000+0200}, author = {Fu, Yan and Zhu, Meng and Xing, Jianhua}, biburl = {https://www.bibsonomy.org/bibtex/2ac357db3ea7d78d25162465ea5a967ff/penkib}, description = {[0909.5125] Resonant activation: a strategy against bacterial persistence}, interhash = {7ccef46f3d3677fbe04f82db382241b3}, intrahash = {ac357db3ea7d78d25162465ea5a967ff}, keywords = {arxiv bacterial_colony}, note = {cite arxiv:0909.5125Comment: 21 pages, 10 figures, submitted}, timestamp = {2009-10-21T04:26:39.000+0200}, title = {Resonant activation: a strategy against bacterial persistence}, url = {http://arxiv.org/abs/0909.5125}, year = 2009 }