Abstract
What can we learn from the first genome sequences obtained from cancerous cells? The human genome is often viewed as fixed and unchanging—a perspective borne out by the availability of many complete sequences of individuals, all of which are essentially static snapshots of the human sequence. The reality is less absolute, however, with the genomes in individual cells or groups of cells changing over time, accumulating somatic mutations and rearrangements, the vast majority of which are benign.
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