%0 Journal Article %1 Falagas2013 %A Falagas, Matthew E. %A Tansarli, Giannoula S. %A Ikawa, Kazuro %A Vardakas, Konstantinos Z. %D 2013 %J Clin Infect Dis %K drug dosage/adverse dosing toxicity %N 2 %P 272--282 %R 10.1093/cid/cis857 %T Clinical outcomes with extended or continuous versus short-term intravenous infusion of carbapenems and piperacillin/tazobactam: a systematic review and meta-analysis. %U http://dx.doi.org/10.1093/cid/cis857 %V 56 %X We sought to study whether the better pharmacokinetic and pharmacodynamic (PK/PD) properties of carbapenems and piperacillin/tazobactam, when the duration of infusion is longer, were associated with lower mortality. PubMed and Scopus were searched for studies reporting on patients treated with extended (≥3 hours) or continuous (24 hours) versus short-term duration (20-60 minutes) infusions of carbapenems or piperacillin/tazobactam. Fourteen studies were included (1229 patients). Mortality was lower among patients receiving extended or continuous infusion of carbapenems or piperacillin/tazobactam compared to those receiving short-term (risk ratio RR, 0.59; 95\% confidence interval CI, .41-.83). Patients with pneumonia who received extended or continuous infusion had lower mortality than those receiving short-term infusion (RR, 0.50; 95\% CI, 0.26-0.96). Data for other specific infections were not available. The available evidence from mainly nonrandomized studies suggests that extended or continuous infusion of carbapenems or piperacillin/tazobactam was associated with lower mortality. Well-designed randomized controlled trials are warranted to confirm these findings before such approaches become widely used.

@article{Falagas2013, abstract = {We sought to study whether the better pharmacokinetic and pharmacodynamic (PK/PD) properties of carbapenems and piperacillin/tazobactam, when the duration of infusion is longer, were associated with lower mortality. PubMed and Scopus were searched for studies reporting on patients treated with extended (≥3 hours) or continuous (24 hours) versus short-term duration (20-60 minutes) infusions of carbapenems or piperacillin/tazobactam. Fourteen studies were included (1229 patients). Mortality was lower among patients receiving extended or continuous infusion of carbapenems or piperacillin/tazobactam compared to those receiving short-term (risk ratio [RR], 0.59; 95\% confidence interval [CI], .41-.83). Patients with pneumonia who received extended or continuous infusion had lower mortality than those receiving short-term infusion (RR, 0.50; 95\% CI, 0.26-0.96). Data for other specific infections were not available. The available evidence from mainly nonrandomized studies suggests that extended or continuous infusion of carbapenems or piperacillin/tazobactam was associated with lower mortality. Well-designed randomized controlled trials are warranted to confirm these findings before such approaches become widely used.}, added-at = {2013-03-06T01:09:20.000+0100}, author = {Falagas, Matthew E. and Tansarli, Giannoula S. and Ikawa, Kazuro and Vardakas, Konstantinos Z.}, biburl = {https://www.bibsonomy.org/bibtex/247847302fdb0360f8088fd96300b51a2/aorchid}, description = {see page 85 in notebook 00002. Good references. Not really good meta analysis.}, doi = {10.1093/cid/cis857}, file = {:ID_General/ClinInfectDis.56.272.pdf:PDF}, groups = {public}, institution = {Alfa Institute of Biomedical Sciences, Greece. m.falagas@aibs.gr}, interhash = {c0dc847d77950a2806f5cf8f89dfe4b1}, intrahash = {47847302fdb0360f8088fd96300b51a2}, journal = {Clin Infect Dis}, keywords = {drug dosage/adverse dosing toxicity}, language = {eng}, medline-pst = {ppublish}, month = Jan, number = 2, pages = {272--282}, pii = {cis857}, pmid = {23074314}, timestamp = {2013-03-06T01:09:20.000+0100}, title = {Clinical outcomes with extended or continuous versus short-term intravenous infusion of carbapenems and piperacillin/tazobactam: a systematic review and meta-analysis.}, url = {http://dx.doi.org/10.1093/cid/cis857}, username = {aorchid}, volume = 56, year = 2013 }