Article,

Sample size calculations in the presence of competing risks

, and .
Stat Med, 26 (30): 5370-5380 (December 2007)
DOI: 10.1002/sim.3114

Abstract

Recently, with the growth of statistical developments for competing risks analysis, some methods have been proposed to compute sample size in this context. These methods differ from a modelling approach: one is based on the Cox regression model for the cause-specific hazard, while another relies on the Fine and Gray regression model for the subdistribution hazard of a competing risk. In this work, we compare these approaches, derive a new sample size for comparing cumulative incidence functions when the hazards are not proportional (either cause-specific or subdistribution) and give practical advices to choose the approach best suited for the study question.

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