%0 Journal Article %1 Bachrach2006 %A Bachrach, Steven J %A Kecskemethy, Heidi H %A Harcke, H. Theodore %A Lark, Robert K %A Miller, Freeman %A Henderson, Richard C %D 2006 %J J Clin Densitom %K Adolescent; Bone Density; Density Conservation Agents; Diseases, Metabolic; Cerebral Palsy; Child; Diphosphonates; Female; Femur; Humans; Male; Retrospective Studies %N 2 %P 167--174 %R 10.1016/j.jocd.2005.11.003 %T Pamidronate treatment and posttreatment bone density in children with spastic quadriplegic cerebral palsy. %U http://dx.doi.org/10.1016/j.jocd.2005.11.003 %V 9 %X Little is known about the long-term effects of a course of pamidronate treatment on bone mineral density (BMD) of children with spastic quadriplegic cerebral palsy (SQCP). Nine patients with SQCP who had low bone density and/or history of previous fracture(s) were studied during treatment and more than 1 yr after cyclic pamidronate treatment ended. Over the 12 mo of treatment, spine BMD increases raised average Z-score from -4.0 to -2.8. In the distal femoral metaphysis, BMD increase raised average Z-score from -3.6 to -1.7. Observations posttreatment ranged from 12 to 49 mo. Changes in BMD were variable among individuals. Group spine Z-score an average of 34 mo posttreatment approached pretreatment value. Six of eight patients had final distal femur posttreatment Z-scores the same or better than pretreatment baseline an average of 27.1 mo later. While most but not all gains in BMD were lost over the first 2 yr after treatment, no patient sustained fracture during or after treatment for a cumulative follow-up of more than 27 patient-yr.

@article{Bachrach2006, abstract = {Little is known about the long-term effects of a course of pamidronate treatment on bone mineral density (BMD) of children with spastic quadriplegic cerebral palsy (SQCP). Nine patients with SQCP who had low bone density and/or history of previous fracture(s) were studied during treatment and more than 1 yr after cyclic pamidronate treatment ended. Over the 12 mo of treatment, spine BMD increases raised average Z-score from -4.0 to -2.8. In the distal femoral metaphysis, BMD increase raised average Z-score from -3.6 to -1.7. Observations posttreatment ranged from 12 to 49 mo. Changes in BMD were variable among individuals. Group spine Z-score an average of 34 mo posttreatment approached pretreatment value. Six of eight patients had final distal femur posttreatment Z-scores the same or better than pretreatment baseline an average of 27.1 mo later. While most but not all gains in BMD were lost over the first 2 yr after treatment, no patient sustained fracture during or after treatment for a cumulative follow-up of more than 27 patient-yr.}, added-at = {2014-07-19T17:51:40.000+0200}, author = {Bachrach, Steven J and Kecskemethy, Heidi H and Harcke, H. Theodore and Lark, Robert K and Miller, Freeman and Henderson, Richard C}, biburl = {https://www.bibsonomy.org/bibtex/2af7ee38e444b4c4aa60b5efef97a5762/ar0berts}, doi = {10.1016/j.jocd.2005.11.003}, groups = {public}, interhash = {ce8df946a589b174cee62a4bbb2f616c}, intrahash = {af7ee38e444b4c4aa60b5efef97a5762}, journal = {J Clin Densitom}, keywords = {Adolescent; Bone Density; Density Conservation Agents; Diseases, Metabolic; Cerebral Palsy; Child; Diphosphonates; Female; Femur; Humans; Male; Retrospective Studies}, number = 2, pages = {167--174}, pii = {S1094-6950(06)00010-2}, pmid = {16785077}, timestamp = {2014-07-19T17:51:40.000+0200}, title = {Pamidronate treatment and posttreatment bone density in children with spastic quadriplegic cerebral palsy.}, url = {http://dx.doi.org/10.1016/j.jocd.2005.11.003}, username = {ar0berts}, volume = 9, year = 2006 }