%0 Journal Article %1 AmyHinYanTong2004Global %A Tong, Amy Hin Yan %A Lesage, Guillaume %A Bader, Gary D. %A Ding, Huiming %A Xu, Hong %A Xin, Xiaofeng %A Young, James %A Berriz, Gabriel F. %A Brost, Renee L. %A Chang, Michael %A Chen, YiQun %A Cheng, Xin %A Chua, Gordon %A Friesen, Helena %A Goldberg, Debra S. %A Haynes, Jennifer %A Humphries, Christine %A He, Grace %A Hussein, Shamiza %A Ke, Lizhu %A Krogan, Nevan %A Li, Zhijian %A Levinson, Joshua N. %A Lu, Hong %A Ménard, Patrice %A Munyana, Christella %A Parsons, Ainslie B. %A Ryan, Owen %A Tonikian, Raffi %A Roberts, Tania %A Sdicu, Anne-Marie %A Shapiro, Jesse %A Sheikh, Bilal %A Suter, Bernhard %A Wong, Sharyl L. %A Zhang, Lan V. %A Zhu, Hongwei %A Burd, Christopher G. %A Munro, Sean %A Sander, Chris %A Rine, Jasper %A Greenblatt, Jack %A Peter, Matthias %A Bretscher, Anthony %A Bell, Graham %A Roth, Frederick P. %A Brown, Grant W. %A Andrews, Brenda %A Bussey, Howard %A Boone, Charles %D 2004 %I American Association for the Advancement of Science %J Science %K synthetic-lethality yeast %N 5659 %P 808--813 %R 10.1126/science.1091317 %T Global Mapping of the Yeast Genetic Interaction Network %U http://dx.doi.org/10.1126/science.1091317 %V 303 %X A genetic interaction network containing ∼1000 genes and ∼4000 interactions was mapped by crossing mutations in 132 different query genes into a set of ∼4700 viable gene yeast deletion mutants and scoring the double mutant progeny for fitness defects. Network connectivity was predictive of function because interactions often occurred among functionally related genes, and similar patterns of interactions tended to identify components of the same pathway. The genetic network exhibited dense local neighborhoods; therefore, the position of a gene on a partially mapped network is predictive of other genetic interactions. Because digenic interactions are common in yeast, similar networks may underlie the complex genetics associated with inherited phenotypes in other organisms.

@article{AmyHinYanTong2004Global, abstract = {A genetic interaction network containing ∼1000 genes and ∼4000 interactions was mapped by crossing mutations in 132 different query genes into a set of ∼4700 viable gene yeast deletion mutants and scoring the double mutant progeny for fitness defects. Network connectivity was predictive of function because interactions often occurred among functionally related genes, and similar patterns of interactions tended to identify components of the same pathway. The genetic network exhibited dense local neighborhoods; therefore, the position of a gene on a partially mapped network is predictive of other genetic interactions. Because digenic interactions are common in yeast, similar networks may underlie the complex genetics associated with inherited phenotypes in other organisms.}, added-at = {2018-12-02T16:09:07.000+0100}, author = {Tong, Amy Hin Yan and Lesage, Guillaume and Bader, Gary D. and Ding, Huiming and Xu, Hong and Xin, Xiaofeng and Young, James and Berriz, Gabriel F. and Brost, Renee L. and Chang, Michael and Chen, YiQun and Cheng, Xin and Chua, Gordon and Friesen, Helena and Goldberg, Debra S. and Haynes, Jennifer and Humphries, Christine and He, Grace and Hussein, Shamiza and Ke, Lizhu and Krogan, Nevan and Li, Zhijian and Levinson, Joshua N. and Lu, Hong and M\'{e}nard, Patrice and Munyana, Christella and Parsons, Ainslie B. and Ryan, Owen and Tonikian, Raffi and Roberts, Tania and Sdicu, Anne-Marie and Shapiro, Jesse and Sheikh, Bilal and Suter, Bernhard and Wong, Sharyl L. and Zhang, Lan V. and Zhu, Hongwei and Burd, Christopher G. and Munro, Sean and Sander, Chris and Rine, Jasper and Greenblatt, Jack and Peter, Matthias and Bretscher, Anthony and Bell, Graham and Roth, Frederick P. and Brown, Grant W. and Andrews, Brenda and Bussey, Howard and Boone, Charles}, biburl = {https://www.bibsonomy.org/bibtex/28a5955adda19c75f456db9053efb3f12/karthikraman}, citeulike-article-id = {100186}, citeulike-linkout-0 = {http://dx.doi.org/10.1126/science.1091317}, citeulike-linkout-1 = {http://www.sciencemag.org/content/303/5659/808.abstract}, citeulike-linkout-2 = {http://www.sciencemag.org/content/303/5659/808.full.pdf}, citeulike-linkout-3 = {http://www.sciencemag.org/cgi/content/abstract/303/5659/808}, citeulike-linkout-4 = {http://view.ncbi.nlm.nih.gov/pubmed/14764870}, citeulike-linkout-5 = {http://www.hubmed.org/display.cgi?uids=14764870}, citeulike-linkout-6 = {http://www.sciencemag.org/cgi/content/full/303/5659/808}, day = 06, doi = {10.1126/science.1091317}, interhash = {d8c2c226737f6b52d12cc9ca3b017b2a}, intrahash = {8a5955adda19c75f456db9053efb3f12}, issn = {1095-9203}, journal = {Science}, keywords = {synthetic-lethality yeast}, month = feb, number = 5659, pages = {808--813}, pmid = {14764870}, posted-at = {2014-11-05 18:02:54}, priority = {2}, publisher = {American Association for the Advancement of Science}, timestamp = {2018-12-02T16:09:07.000+0100}, title = {Global Mapping of the Yeast Genetic Interaction Network}, url = {http://dx.doi.org/10.1126/science.1091317}, volume = 303, year = 2004 }