%0 Journal Article %1 Kassubek:BrainTopogr:1999 %A Kassubek, J. %A Sörös, P. %A Kober, H. %A Stippich, C. %A Vieth, J. B. %C UNITED STATES %D 1999 %J Brain Topogr %K Aged;Beta Magnetoencephalography;Multiple Rhythm;Brain;Female;Reference Sclerosis;Humans;Middle Values;Male;Adult;Adolescent %N 3 %P 193-200 %T Focal slow and beta brain activity in patients with multiple sclerosis revealed by magnetoencephalography. %V 11 %X In multiple sclerosis (MS) inflammatory infiltrations cause white matter lesions. Magnetoencephalography (MEG) offers the opportunity to localize abnormal electric activity of neurons with a high spatio-temporal resolution. In this study, we investigated patients with MS in order to find if abnormal cortical activity is associated with (subcortical) MS lesions using simultaneous bilateral recording of biomagnetic activity. Eight patients suffering from definite laboratory-supported MS with mainly somatosensory deficits and multiple bihemispheric plaques revealed by MRI were included in the study. To obtain normative data, 8 healthy volunteers were investigated following the same measuring protocol. Spontaneous magnetic brain activity was recorded using a 2x37-channel biomagnetic system (BTI, USA). Offline analysis included digital filtering (to separately investigate slow and beta wave activity), a Principle Component Analysis and the Dipole Density Plot. Localization results were inserted into MR images using our contour fit procedure. The dipole distribution in the brain was quantified and compared between the groups by statistical analysis. In all MS patients, the maximum of focal abnormal activity was localized in cortical areas adjacent to the fiber lesions. In the healthy subjects, no focal abnormal brain activity could be found. However, the standardized maximum concentrations of dipoles were significantly higher in the MS patients than in the healthy control group both in the slow and in the beta wave analysis. These results let assume that subcortical lesions can occur together with abnormal cortical neuronal activity. The results are discussed in respect to their impact on the interpretation of the analysis of spontaneous magnetic brain activity.

@article{Kassubek:BrainTopogr:1999, abstract = {In multiple sclerosis (MS) inflammatory infiltrations cause white matter lesions. Magnetoencephalography (MEG) offers the opportunity to localize abnormal electric activity of neurons with a high spatio-temporal resolution. In this study, we investigated patients with MS in order to find if abnormal cortical activity is associated with (subcortical) MS lesions using simultaneous bilateral recording of biomagnetic activity. Eight patients suffering from definite laboratory-supported MS with mainly somatosensory deficits and multiple bihemispheric plaques revealed by MRI were included in the study. To obtain normative data, 8 healthy volunteers were investigated following the same measuring protocol. Spontaneous magnetic brain activity was recorded using a 2x37-channel biomagnetic system (BTI, USA). Offline analysis included digital filtering (to separately investigate slow and beta wave activity), a Principle Component Analysis and the Dipole Density Plot. Localization results were inserted into MR images using our contour fit procedure. The dipole distribution in the brain was quantified and compared between the groups by statistical analysis. In all MS patients, the maximum of focal abnormal activity was localized in cortical areas adjacent to the fiber lesions. In the healthy subjects, no focal abnormal brain activity could be found. However, the standardized maximum concentrations of dipoles were significantly higher in the MS patients than in the healthy control group both in the slow and in the beta wave analysis. These results let assume that subcortical lesions can occur together with abnormal cortical neuronal activity. The results are discussed in respect to their impact on the interpretation of the analysis of spontaneous magnetic brain activity.}, added-at = {2012-04-29T04:45:51.000+0200}, address = {UNITED STATES}, author = {Kassubek, J. and Sörös, P. and Kober, H. and Stippich, C. and Vieth, J. B.}, biburl = {https://www.bibsonomy.org/bibtex/23f81d036e7d81db696db079c373cd053/asterix}, interhash = {e52fe09e5a3f8cf695a95746819243cf}, intrahash = {3f81d036e7d81db696db079c373cd053}, issn = {0896-0267}, journal = {Brain Topogr}, keywords = {Aged;Beta Magnetoencephalography;Multiple Rhythm;Brain;Female;Reference Sclerosis;Humans;Middle Values;Male;Adult;Adolescent}, number = 3, organization = {Department of Experimental Neuropsychiatry, University of Erlangen-Nürnberg, Germany. kassubek\@nz11.ukl.uni-freiburg.de}, pages = {193-200}, primary_contributor_role = {Author}, publicationstatus = {Published}, pubmedid = {10217443}, sentelink = {file://localhost/Users/peter/Projects/Literature/Sente6/SenteLibrary.sente6lib/Contents/Attachments/Kassubek/Focal%20slow%20and%20beta%20brain%20activity%20in%20patients%20with%20multiple%20sclerosis%20revealed%20by%20magnetoencephalog.pdf,Sente,}, timestamp = {2012-04-29T04:45:55.000+0200}, title = {Focal slow and beta brain activity in patients with multiple sclerosis revealed by magnetoencephalography.}, us_nlm_id = {8903034}, uuid = {6CC2019C-CBF9-429F-A07F-9D84931EFB61}, volume = 11, web_data_source = {PubMed}, year = 1999 }