%0 Journal Article %1 Bern_2002_H2296 %A Bernus, O. %A Wilders, R. %A Zemlin, C. W. %A Verschelde, H. %A Panfilov, A. V. %D 2002 %J Am. J. Physiol. Heart Circ. Physiol. %K 12003840 Action Animals, Arrhythmia, Biological, Channel Channels, Computer Conductivity, Electric Electrophysiology, Endocardium, Gating, Gov't, Heart Humans, Ion Mathematics, Membrane Models, Non-U.S. Pericardium, Potassium Potentials, Research Simulation, Sodium Support, Ventricles, %N 6 %P H2296-308 %R 10.1152/ajpheart.00731.2001 %T A computationally efficient electrophysiological model of human ventricular cells. %U http://dx.doi.org/10.1152/ajpheart.00731.2001 %V 282 %X Recent experimental and theoretical results have stressed the importance of modeling studies of reentrant arrhythmias in cardiac tissue and at the whole heart level. We introduce a six-variable model obtained by a reformulation of the Priebe-Beuckelmann model of a single human ventricular cell. The reformulated model is 4.9 times faster for numerical computations and it is more stable than the original model. It retains the action potential shape at various frequencies, restitution of action potential duration, and restitution of conduction velocity. We were able to reproduce the main properties of epicardial, endocardial, and M cells by modifying selected ionic currents. We performed a simulation study of spiral wave behavior in a two-dimensional sheet of human ventricular tissue and showed that spiral waves have a frequency of 3.3 Hz and a linear core of approximately 50-mm diameter that rotates with an average frequency of 0.62 rad/s. Simulation results agreed with experimental data. In conclusion, the proposed model is suitable for efficient and accurate studies of reentrant phenomena in human ventricular tissue.

@article{Bern_2002_H2296, abstract = {Recent experimental and theoretical results have stressed the importance of modeling studies of reentrant arrhythmias in cardiac tissue and at the whole heart level. We introduce a six-variable model obtained by a reformulation of the Priebe-Beuckelmann model of a single human ventricular cell. The reformulated model is 4.9 times faster for numerical computations and it is more stable than the original model. It retains the action potential shape at various frequencies, restitution of action potential duration, and restitution of conduction velocity. We were able to reproduce the main properties of epicardial, endocardial, and M cells by modifying selected ionic currents. We performed a simulation study of spiral wave behavior in a two-dimensional sheet of human ventricular tissue and showed that spiral waves have a frequency of 3.3 Hz and a linear core of approximately 50-mm diameter that rotates with an average frequency of 0.62 rad/s. Simulation results agreed with experimental data. In conclusion, the proposed model is suitable for efficient and accurate studies of reentrant phenomena in human ventricular tissue.}, added-at = {2009-06-03T11:20:58.000+0200}, author = {Bernus, O. and Wilders, R. and Zemlin, C. W. and Verschelde, H. and Panfilov, A. V.}, biburl = {https://www.bibsonomy.org/bibtex/209957bea0eda2f2fbd39c44b6b02972a/hake}, description = {The whole bibliography file I use.}, doi = {10.1152/ajpheart.00731.2001}, file = {Bern_2002_H2296.pdf:Bern_2002_H2296.pdf:PDF}, interhash = {2bc124bdc035dd4d9cd07561fa12ba1c}, intrahash = {09957bea0eda2f2fbd39c44b6b02972a}, journal = {Am. J. Physiol. Heart Circ. Physiol.}, key = 14, keywords = {12003840 Action Animals, Arrhythmia, Biological, Channel Channels, Computer Conductivity, Electric Electrophysiology, Endocardium, Gating, Gov't, Heart Humans, Ion Mathematics, Membrane Models, Non-U.S. Pericardium, Potassium Potentials, Research Simulation, Sodium Support, Ventricles,}, month = Jun, number = 6, pages = {H2296-308}, timestamp = {2009-06-03T11:21:02.000+0200}, title = {A computationally efficient electrophysiological model of human ventricular cells.}, url = {http://dx.doi.org/10.1152/ajpheart.00731.2001}, volume = 282, year = 2002 }