Rose Bengal@alpha-cyclodextrin (RB@alpha-CD) microparticles (mu Ps) were
prepared and the RB inclusion in alpha-CD was experimentally
demonstrated through infrared, UV-VIS absorption spectroscopy and cyclic
voltammetry. The RB inclusion in alpha-CD was theoretically investigated
using classical molecular mechanics calculations, the simulation results
showing that RB can be included in both the narrow and wide apertures of
the alpha-cyclodextrin ring with configurations exhibiting average binding energies of about 27 kcal mol(-1). The prepared RB@alpha-CD
microparticles were characterized through Scanning Electron Microscopy
(SEM) and it was demonstrated that they are highly efficient in the
photodynamic therapy against a Streptococcus mutans (the main bacteria
of cariogenic dental plaque) suspension, as a concentration of RB@alpha-CD mu Ps 10 times smaller than the usual concentration of pure
RB is still capable to produce significant antibacterial activity.
%0 Journal Article
%1 WOS:000465059600018
%A Alexandrino, F J R
%A Bezerra, E M
%A Costa, R F Da
%A Cavalcante, L R L
%A Sales, F A M
%A Francisco, T S
%A Rodrigues, L K A
%A de Brito, D H Almeida
%A Ricardo, N M P S
%A Costa, S N
%A de Lima-Neto, P
%A Barroso-Neto, I L
%A Caetano, E W S
%A Freire, V N
%C PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
%D 2019
%I ELSEVIER SCIENCE BV
%J PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
%K Antibacterial Antimicrobial Bengal; Molecular Photodynamic activity; alpha-cyclodextrin interaction microparticles; photodynamic simulations; therapy; therapy} {Rose
%P 111-118
%R 10.1016/j.pdpdt.2018.11.016
%T Rose Bengal incorporated to alpha-cyclodextrin microparticles for
photodynamic therapy against the cariogenic microorganism Streptococcus
mutans
%V 25
%X Rose Bengal@alpha-cyclodextrin (RB@alpha-CD) microparticles (mu Ps) were
prepared and the RB inclusion in alpha-CD was experimentally
demonstrated through infrared, UV-VIS absorption spectroscopy and cyclic
voltammetry. The RB inclusion in alpha-CD was theoretically investigated
using classical molecular mechanics calculations, the simulation results
showing that RB can be included in both the narrow and wide apertures of
the alpha-cyclodextrin ring with configurations exhibiting average binding energies of about 27 kcal mol(-1). The prepared RB@alpha-CD
microparticles were characterized through Scanning Electron Microscopy
(SEM) and it was demonstrated that they are highly efficient in the
photodynamic therapy against a Streptococcus mutans (the main bacteria
of cariogenic dental plaque) suspension, as a concentration of RB@alpha-CD mu Ps 10 times smaller than the usual concentration of pure
RB is still capable to produce significant antibacterial activity.
@article{WOS:000465059600018,
abstract = {Rose Bengal@alpha-cyclodextrin (RB@alpha-CD) microparticles (mu Ps) were
prepared and the RB inclusion in alpha-CD was experimentally
demonstrated through infrared, UV-VIS absorption spectroscopy and cyclic
voltammetry. The RB inclusion in alpha-CD was theoretically investigated
using classical molecular mechanics calculations, the simulation results
showing that RB can be included in both the narrow and wide apertures of
the alpha-cyclodextrin ring with configurations exhibiting average binding energies of about 27 kcal mol(-1). The prepared RB@alpha-CD
microparticles were characterized through Scanning Electron Microscopy
(SEM) and it was demonstrated that they are highly efficient in the
photodynamic therapy against a Streptococcus mutans (the main bacteria
of cariogenic dental plaque) suspension, as a concentration of RB@alpha-CD mu Ps 10 times smaller than the usual concentration of pure
RB is still capable to produce significant antibacterial activity.},
added-at = {2022-05-23T20:00:14.000+0200},
address = {PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS},
author = {Alexandrino, F J R and Bezerra, E M and Costa, R F Da and Cavalcante, L R L and Sales, F A M and Francisco, T S and Rodrigues, L K A and de Brito, D H Almeida and Ricardo, N M P S and Costa, S N and de Lima-Neto, P and Barroso-Neto, I L and Caetano, E W S and Freire, V N},
biburl = {https://www.bibsonomy.org/bibtex/2136be607f320fecf920f897b871194d2/ppgfis_ufc_br},
doi = {10.1016/j.pdpdt.2018.11.016},
interhash = {707e53967a286c1fb24cf6257351152e},
intrahash = {136be607f320fecf920f897b871194d2},
issn = {1572-1000},
journal = {PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY},
keywords = {Antibacterial Antimicrobial Bengal; Molecular Photodynamic activity; alpha-cyclodextrin interaction microparticles; photodynamic simulations; therapy; therapy} {Rose},
pages = {111-118},
publisher = {ELSEVIER SCIENCE BV},
pubstate = {published},
timestamp = {2022-05-23T20:00:14.000+0200},
title = {Rose Bengal incorporated to alpha-cyclodextrin microparticles for
photodynamic therapy against the cariogenic microorganism Streptococcus
mutans},
tppubtype = {article},
volume = 25,
year = 2019
}