Circuit model for microfluidic bubble generation under controlled pressure
15 (6):
797--805 (2013)DOI: 10.1007/s10404-013-1189-6
Abstract
We explore the microfluidic generation of bubbles in a flow-focusing junction using a pressure-controlled device rather than the more common flow rate-controlled devices. This device is a prototype for extending microfluidic drop generation methods to molten polymers. We show that the bubble generation process is highly sensitive to pressure: small changes in pressure induce large changes in bubble size and bubble formation frequency. A simple resistance circuit model can explain this pressure dependence. Briefly, we show that bubble generation is possible only within a finite pressure range. Near the ends of this pressure range, the ratio of the flow rates of the dispersed to continuous phase is highly sensitive to pressure, and therefore so also is the bubble generation process. The circuit model offers a way to use existing models of drop generation (which are based on flow rate-controlled operation) to predict pressure-controlled operation. We also examine drop formation using a highly viscous polymer as the dispersed phase. Drops are formed far downstream of the flow-focusing junction, and they are far smaller than the microfluidic channel dimensions. These results suggest that existing microfluidic drop generation methods may be exploited to make complex particles from thermoplastic polymers.