%0 Journal Article %1 AHern2001 %A A'Hern, R P %D 2001 %J Statistics in medicine %K Antiemetics Antiemetics:standards Antiemetics:therapeuticuse BinomialDistribution Breast Breast:secretion ClinicalTrials ExudatesandTransudates ExudatesandTransudates:chemistry ExudatesandTransudates:cytology Humans Nausea Nausea:drugtherapy PhaseIIIasTopic PhaseIIIasTopic:methods PhaseIIasTopic PhaseIIasTopic:methods SampleSize StatisticsasTopic RCT %N 6 %P 859-66 %R 10.1002/sim.721 %T Sample size tables for exact single-stage phase II designs. %U http://www.ncbi.nlm.nih.gov/pubmed/11252008 %V 20 %X Tables for single-phase II trials based on the exact binomial distribution are presented. These are preferable to those generated using Fleming's design, which are based on the normal approximation and can give rise to anomalous results. For example, if the upper success rate is accepted, the lower success rate, which the trial is designed to reject, may be included in the final confidence interval for the proportion being estimated. %@ 0277-6715

@article{AHern2001, abstract = {Tables for single-phase II trials based on the exact binomial distribution are presented. These are preferable to those generated using Fleming's design, which are based on the normal approximation and can give rise to anomalous results. For example, if the upper success rate is accepted, the lower success rate, which the trial is designed to reject, may be included in the final confidence interval for the proportion being estimated.}, added-at = {2023-02-03T11:44:35.000+0100}, author = {A'Hern, R P}, biburl = {https://www.bibsonomy.org/bibtex/25c77a29a751f282a12a95f1a495c55c9/jepcastel}, city = {Department of Computing and Information, Royal Marsden NHS Trust, Fulham Road, London SW3 6JJ, UK.}, doi = {10.1002/sim.721}, interhash = {2451dc80b21c00158451ef8303b93cf7}, intrahash = {5c77a29a751f282a12a95f1a495c55c9}, isbn = {0277-6715}, issn = {0277-6715}, journal = {Statistics in medicine}, keywords = {Antiemetics Antiemetics:standards Antiemetics:therapeuticuse BinomialDistribution Breast Breast:secretion ClinicalTrials ExudatesandTransudates ExudatesandTransudates:chemistry ExudatesandTransudates:cytology Humans Nausea Nausea:drugtherapy PhaseIIIasTopic PhaseIIIasTopic:methods PhaseIIasTopic PhaseIIasTopic:methods SampleSize StatisticsasTopic RCT}, month = {3}, note = {5264<m:linebreak></m:linebreak>LR: 20071115; CI: Copyright 2001; JID: 8215016; 0 (Antiemetics); ppublish;<m:linebreak></m:linebreak>Fase II; Sample size}, number = 6, pages = {859-66}, pmid = {11252008}, timestamp = {2023-05-04T09:00:45.000+0200}, title = {Sample size tables for exact single-stage phase II designs.}, url = {http://www.ncbi.nlm.nih.gov/pubmed/11252008}, volume = 20, year = 2001 }