Complex Function Sets Improve Symbolic Discriminant
Analysis of Microarray Data
D. Reif, B. White, N. Olsen, T. Aune, and J. Moore. Genetic and Evolutionary Computation -- GECCO-2003, volume 2724 of LNCS, page 2277--2287. Chicago, Springer-Verlag, (12-16 July 2003)
Abstract
Our ability to simultaneously measure the expression
levels of thousands of genes in biological samples is
providing important new opportunities for improving the
diagnosis, prevention, and treatment of common
diseases. However, new technologies such as DNA
microarrays are generating new challenges for variable
selection and statistical modeling. In response to
these challenges, a genetic programming-based strategy
called symbolic discriminant analysis (SDA) for the
automatic selection of gene expression variables and
mathematical functions for statistical modeling of
clinical endpoints has been developed. The initial
development and evaluation of SDA has focused on a
function set consisting of only the four basic
arithmetic operators. The goal of the present study is
to evaluate whether adding more complex operators such
as square root to the function set improves SDA
modeling of microarray data. The results presented in
this paper demonstrate that adding complex functions to
the terminal set significantly improves SDA modeling by
reducing model size and, in some cases, reducing
classification error and runtime. We anticipate SDA
will be an important new evolutionary computation tool
to be added to the repertoire of methods for the
analysis of microarray data.
Genetic and Evolutionary Computation -- GECCO-2003
year
2003
month
12-16 July
pages
2277--2287
publisher
Springer-Verlag
series
LNCS
volume
2724
publisher_address
Berlin
size
12 pages
isbn
3-540-40603-4
notes
GECCO-2003 A joint meeting of the twelvth
international conference on genetic algorithms
(ICGA-99) and the eigth annual genetic programming
conference (GP-2003)
square, sqrt, log, exp, abs, sin,cosine. lilgp. PVM, 2
demes, LOOCV. systemic lupus erythematosus.
%0 Conference Paper
%1 reif:2003:gecco
%A Reif, David M.
%A White, Bill C.
%A Olsen, Nancy
%A Aune, Thomas
%A Moore, Jason H.
%B Genetic and Evolutionary Computation -- GECCO-2003
%C Chicago
%D 2003
%E Cantú-Paz, E.
%E Foster, J. A.
%E Deb, K.
%E Davis, D.
%E Roy, R.
%E O'Reilly, U.-M.
%E Beyer, H.-G.
%E Standish, R.
%E Kendall, G.
%E Wilson, S.
%E Harman, M.
%E Wegener, J.
%E Dasgupta, D.
%E Potter, M. A.
%E Schultz, A. C.
%E Dowsland, K.
%E Jonoska, N.
%E Miller, J.
%I Springer-Verlag
%K Applications Real World algorithms, genetic programming,
%P 2277--2287
%T Complex Function Sets Improve Symbolic Discriminant
Analysis of Microarray Data
%V 2724
%X Our ability to simultaneously measure the expression
levels of thousands of genes in biological samples is
providing important new opportunities for improving the
diagnosis, prevention, and treatment of common
diseases. However, new technologies such as DNA
microarrays are generating new challenges for variable
selection and statistical modeling. In response to
these challenges, a genetic programming-based strategy
called symbolic discriminant analysis (SDA) for the
automatic selection of gene expression variables and
mathematical functions for statistical modeling of
clinical endpoints has been developed. The initial
development and evaluation of SDA has focused on a
function set consisting of only the four basic
arithmetic operators. The goal of the present study is
to evaluate whether adding more complex operators such
as square root to the function set improves SDA
modeling of microarray data. The results presented in
this paper demonstrate that adding complex functions to
the terminal set significantly improves SDA modeling by
reducing model size and, in some cases, reducing
classification error and runtime. We anticipate SDA
will be an important new evolutionary computation tool
to be added to the repertoire of methods for the
analysis of microarray data.
%@ 3-540-40603-4
@inproceedings{reif:2003:gecco,
abstract = {Our ability to simultaneously measure the expression
levels of thousands of genes in biological samples is
providing important new opportunities for improving the
diagnosis, prevention, and treatment of common
diseases. However, new technologies such as DNA
microarrays are generating new challenges for variable
selection and statistical modeling. In response to
these challenges, a genetic programming-based strategy
called symbolic discriminant analysis (SDA) for the
automatic selection of gene expression variables and
mathematical functions for statistical modeling of
clinical endpoints has been developed. The initial
development and evaluation of SDA has focused on a
function set consisting of only the four basic
arithmetic operators. The goal of the present study is
to evaluate whether adding more complex operators such
as square root to the function set improves SDA
modeling of microarray data. The results presented in
this paper demonstrate that adding complex functions to
the terminal set significantly improves SDA modeling by
reducing model size and, in some cases, reducing
classification error and runtime. We anticipate SDA
will be an important new evolutionary computation tool
to be added to the repertoire of methods for the
analysis of microarray data.},
added-at = {2008-06-19T17:46:40.000+0200},
address = {Chicago},
author = {Reif, David M. and White, Bill C. and Olsen, Nancy and Aune, Thomas and Moore, Jason H.},
biburl = {https://www.bibsonomy.org/bibtex/2483ecb5dd10e7a7d0951c2616f1e5b81/brazovayeye},
booktitle = {Genetic and Evolutionary Computation -- GECCO-2003},
editor = {Cant{\'u}-Paz, E. and Foster, J. A. and Deb, K. and Davis, D. and Roy, R. and O'Reilly, U.-M. and Beyer, H.-G. and Standish, R. and Kendall, G. and Wilson, S. and Harman, M. and Wegener, J. and Dasgupta, D. and Potter, M. A. and Schultz, A. C. and Dowsland, K. and Jonoska, N. and Miller, J.},
interhash = {0f4e7ca39cb9c1e26a98a0d5f7fbe06d},
intrahash = {483ecb5dd10e7a7d0951c2616f1e5b81},
isbn = {3-540-40603-4},
keywords = {Applications Real World algorithms, genetic programming,},
month = {12-16 July},
notes = {GECCO-2003 A joint meeting of the twelvth
international conference on genetic algorithms
(ICGA-99) and the eigth annual genetic programming
conference (GP-2003)
square, sqrt, log, exp, abs, sin,cosine. lilgp. PVM, 2
demes, LOOCV. systemic lupus erythematosus.},
pages = {2277--2287},
publisher = {Springer-Verlag},
publisher_address = {Berlin},
series = {LNCS},
size = {12 pages},
timestamp = {2008-06-19T17:50:10.000+0200},
title = {Complex Function Sets Improve Symbolic Discriminant
Analysis of Microarray Data},
volume = 2724,
year = 2003
}