OBJECTIVE: To determine whether regular aspirin use is associated with a higher risk for developing age-related macular degeneration (AMD) by using analyzed data from a 15-year prospective cohort. METHODS: A prospective analysis was conducted of data from an Australian population-based cohort with 4 examinations during a 15-year period (1992-1994 to 2007-2009). Participants completed a detailed questionnaire at baseline assessing aspirin use, cardiovascular disease status, and AMD risk factors. Age-related macular degeneration was graded side-by-side from retinal photographs taken at each study visit to assess the incidence of neovascular (wet) AMD and geographic atrophy (dry AMD) according to the international AMD classification. RESULTS: Of 2389 baseline participants with follow-up data available, 257 individuals (10.8%) were regular aspirin users and 63 of the 2389 developed neovascular AMD. Persons who were regular aspirin users were more likely to have incident neovascular AMD: the 15-year cumulative incidence was 9.3% in users and 3.7% in nonusers. After adjustment for age, sex, smoking, history of cardiovascular disease, systolic blood pressure, and body mass index, persons who were regular aspirin users had a higher risk of developing neovascular AMD (odds ratio OR, 2.46; 95% CI, 1.25-4.83). The association showed a dose-response effect (multivariate-adjusted P = .01 for trend). Aspirin use was not associated with the incidence of geographic atrophy (multivariate-adjusted OR, 0.99; 95% CI, 0.59-1.65). CONCLUSION: Regular aspirin use is associated with increased risk of incident neovascular AMD, independent of a history of cardiovascular disease and smoking.
%0 Journal Article
%1 Liew2013
%A Liew, Gerald
%A Mitchell, Paul
%A Wong, Tien Yin
%A Rochtchina, Elena
%A Wang, Jie Jin
%D 2013
%J JAMA internal medicine
%K 80andover Aged Aspirin Aspirin:administration&dosage Aspirin:adverseeffects Australia CardiovascularDiseases CardiovascularDiseases:drugtherapy CardiovascularDiseases:prevention&control CohortStudies Female Humans Incidence LogisticModels MacularDegeneration MacularDegeneration:classification MacularDegeneration:epidemiology MacularDegeneration:etiology Male MiddleAged ProspectiveStudies RiskFactors Smoking
%N 4
%P 258-64
%R 10.1001/jamainternmed.2013.1583
%T The association of aspirin use with age-related macular degeneration.
%U http://www.ncbi.nlm.nih.gov/pubmed/23337937
%V 173
%X OBJECTIVE: To determine whether regular aspirin use is associated with a higher risk for developing age-related macular degeneration (AMD) by using analyzed data from a 15-year prospective cohort. METHODS: A prospective analysis was conducted of data from an Australian population-based cohort with 4 examinations during a 15-year period (1992-1994 to 2007-2009). Participants completed a detailed questionnaire at baseline assessing aspirin use, cardiovascular disease status, and AMD risk factors. Age-related macular degeneration was graded side-by-side from retinal photographs taken at each study visit to assess the incidence of neovascular (wet) AMD and geographic atrophy (dry AMD) according to the international AMD classification. RESULTS: Of 2389 baseline participants with follow-up data available, 257 individuals (10.8%) were regular aspirin users and 63 of the 2389 developed neovascular AMD. Persons who were regular aspirin users were more likely to have incident neovascular AMD: the 15-year cumulative incidence was 9.3% in users and 3.7% in nonusers. After adjustment for age, sex, smoking, history of cardiovascular disease, systolic blood pressure, and body mass index, persons who were regular aspirin users had a higher risk of developing neovascular AMD (odds ratio OR, 2.46; 95% CI, 1.25-4.83). The association showed a dose-response effect (multivariate-adjusted P = .01 for trend). Aspirin use was not associated with the incidence of geographic atrophy (multivariate-adjusted OR, 0.99; 95% CI, 0.59-1.65). CONCLUSION: Regular aspirin use is associated with increased risk of incident neovascular AMD, independent of a history of cardiovascular disease and smoking.
@article{Liew2013,
abstract = {OBJECTIVE: To determine whether regular aspirin use is associated with a higher risk for developing age-related macular degeneration (AMD) by using analyzed data from a 15-year prospective cohort. METHODS: A prospective analysis was conducted of data from an Australian population-based cohort with 4 examinations during a 15-year period (1992-1994 to 2007-2009). Participants completed a detailed questionnaire at baseline assessing aspirin use, cardiovascular disease status, and AMD risk factors. Age-related macular degeneration was graded side-by-side from retinal photographs taken at each study visit to assess the incidence of neovascular (wet) AMD and geographic atrophy (dry AMD) according to the international AMD classification. RESULTS: Of 2389 baseline participants with follow-up data available, 257 individuals (10.8%) were regular aspirin users and 63 of the 2389 developed neovascular AMD. Persons who were regular aspirin users were more likely to have incident neovascular AMD: the 15-year cumulative incidence was 9.3% in users and 3.7% in nonusers. After adjustment for age, sex, smoking, history of cardiovascular disease, systolic blood pressure, and body mass index, persons who were regular aspirin users had a higher risk of developing neovascular AMD (odds ratio [OR], 2.46; 95% CI, 1.25-4.83). The association showed a dose-response effect (multivariate-adjusted P = .01 for trend). Aspirin use was not associated with the incidence of geographic atrophy (multivariate-adjusted OR, 0.99; 95% CI, 0.59-1.65). CONCLUSION: Regular aspirin use is associated with increased risk of incident neovascular AMD, independent of a history of cardiovascular disease and smoking.},
added-at = {2023-02-03T11:44:35.000+0100},
author = {Liew, Gerald and Mitchell, Paul and Wong, Tien Yin and Rochtchina, Elena and Wang, Jie Jin},
biburl = {https://www.bibsonomy.org/bibtex/2535f9e76c4b514311725ec72b178287a/jepcastel},
city = {United States},
doi = {10.1001/jamainternmed.2013.1583},
interhash = {d2b5c9b1d7089f1aea10dd96e0cf8b20},
intrahash = {535f9e76c4b514311725ec72b178287a},
issn = {2168-6114},
journal = {JAMA internal medicine},
keywords = {80andover Aged Aspirin Aspirin:administration&dosage Aspirin:adverseeffects Australia CardiovascularDiseases CardiovascularDiseases:drugtherapy CardiovascularDiseases:prevention&control CohortStudies Female Humans Incidence LogisticModels MacularDegeneration MacularDegeneration:classification MacularDegeneration:epidemiology MacularDegeneration:etiology Male MiddleAged ProspectiveStudies RiskFactors Smoking},
month = {2},
note = {JID: 101589534; ppublish;<m:linebreak></m:linebreak>
<m:linebreak></m:linebreak>Causalitat; Exemple},
number = 4,
pages = {258-64},
pmid = {23337937},
timestamp = {2023-02-03T11:44:35.000+0100},
title = {The association of aspirin use with age-related macular degeneration.},
url = {http://www.ncbi.nlm.nih.gov/pubmed/23337937},
volume = 173,
year = 2013
}