New meningococcal vaccines are undergoing clinical trials, and changes in the epidemiologic features of meningococcal disease will affect their use. Active laboratory-based, population-based US surveillance for meningococcal disease during 1992-1996 was used to project that 2400 cases of meningococcal disease occurred annually. Incidence was highest in infants; however, 32\% of cases occurred in persons \textgreater/=30 years of age. Serogroup C caused 35\% of cases; serogroup B, 32\%; and serogroup Y, 26\%. Increasing age (relative risk RR, 1.01 per year), having an isolate obtained from blood (RR, 4.5), and serogroup C (RR, 1.6) were associated with increased case fatality. Among serogroup B isolates, the most commonly expressed serosubtype was P1.15; 68\% of isolates expressed 1 of the 6 most common serosubtypes. Compared with cases occurring in previous years, recent cases are more likely to be caused by serogroup Y and to occur among older age groups. Ongoing surveillance is necessary to determine the stability of serogroup and serosubtype distribution.
%0 Journal Article
%1 rosenstein_changing_1999
%A Rosenstein, N E
%A Perkins, B A
%A Stephens, D S
%A Lefkowitz, L
%A Cartter, M L
%A Danila, R
%A Cieslak, P
%A Shutt, K A
%A Popovic, T
%A Schuchat, A
%A Harrison, L H
%A Reingold, A L
%D 1999
%J The Journal of Infectious Diseases
%K 80 Adolescent, Adult, Age Aged, Child, Distribution, Electrophoresis, Enzymes, Female, Humans, Incidence, Infant, Infections, Male, Meningococcal Middle Neisseria Newborn, Population Preschool, Prevalence, Seasons, Serotyping, Sex States Surveillance, United and meningitidis, over,
%N 6
%P 1894--901
%R 10.1086/315158
%T The changing epidemiology of meningococcal disease in the United States, 1992-1996
%U http://www.ncbi.nlm.nih.gov/pubmed/10558946
%V 180
%X New meningococcal vaccines are undergoing clinical trials, and changes in the epidemiologic features of meningococcal disease will affect their use. Active laboratory-based, population-based US surveillance for meningococcal disease during 1992-1996 was used to project that 2400 cases of meningococcal disease occurred annually. Incidence was highest in infants; however, 32\% of cases occurred in persons \textgreater/=30 years of age. Serogroup C caused 35\% of cases; serogroup B, 32\%; and serogroup Y, 26\%. Increasing age (relative risk RR, 1.01 per year), having an isolate obtained from blood (RR, 4.5), and serogroup C (RR, 1.6) were associated with increased case fatality. Among serogroup B isolates, the most commonly expressed serosubtype was P1.15; 68\% of isolates expressed 1 of the 6 most common serosubtypes. Compared with cases occurring in previous years, recent cases are more likely to be caused by serogroup Y and to occur among older age groups. Ongoing surveillance is necessary to determine the stability of serogroup and serosubtype distribution.
@article{rosenstein_changing_1999,
abstract = {New meningococcal vaccines are undergoing clinical trials, and changes in the epidemiologic features of meningococcal disease will affect their use. Active laboratory-based, population-based {US} surveillance for meningococcal disease during 1992-1996 was used to project that 2400 cases of meningococcal disease occurred annually. Incidence was highest in infants; however, 32\% of cases occurred in persons {\textgreater}/=30 years of age. Serogroup C caused 35\% of cases; serogroup B, 32\%; and serogroup Y, 26\%. Increasing age (relative risk {[RR],} 1.01 per year), having an isolate obtained from blood {(RR,} 4.5), and serogroup C {(RR,} 1.6) were associated with increased case fatality. Among serogroup B isolates, the most commonly expressed serosubtype was P1.15; 68\% of isolates expressed 1 of the 6 most common serosubtypes. Compared with cases occurring in previous years, recent cases are more likely to be caused by serogroup Y and to occur among older age groups. Ongoing surveillance is necessary to determine the stability of serogroup and serosubtype distribution.},
added-at = {2011-03-11T10:05:34.000+0100},
author = {Rosenstein, N E and Perkins, B A and Stephens, D S and Lefkowitz, L and Cartter, M L and Danila, R and Cieslak, P and Shutt, K A and Popovic, T and Schuchat, A and Harrison, L H and Reingold, A L},
biburl = {https://www.bibsonomy.org/bibtex/27d9387ec8696fc7223f510e0f7211562/jelias},
doi = {10.1086/315158},
interhash = {a3b2da5c03cd1282de8ac12fdc020d84},
intrahash = {7d9387ec8696fc7223f510e0f7211562},
issn = {0022-1899},
journal = {The Journal of Infectious Diseases},
keywords = {80 Adolescent, Adult, Age Aged, Child, Distribution, Electrophoresis, Enzymes, Female, Humans, Incidence, Infant, Infections, Male, Meningococcal Middle Neisseria Newborn, Population Preschool, Prevalence, Seasons, Serotyping, Sex States Surveillance, United and meningitidis, over,},
month = dec,
note = {{PMID:} 10558946},
number = 6,
pages = {1894--901},
timestamp = {2011-03-11T10:06:14.000+0100},
title = {The changing epidemiology of meningococcal disease in the United States, 1992-1996},
url = {http://www.ncbi.nlm.nih.gov/pubmed/10558946},
volume = 180,
year = 1999
}