%0 Journal Article %1 klotz1990ivermectin %A Klotz, U. %A Ogbuokiri, J. E. %A Okonkwo, P. O. %D 1990 %J European Journal of Clinical Pharmacology %K ivermectin plasma_proteins %N 6 %P 607--608 %R 10.1007/BF00316107 %T Ivermectin binds avidly to plasma proteins %U https://doi.org/10.1007/BF00316107 %V 39 %X Human pharmacokinetic data on the new antiparasitic agent, ivermectin, are scanty. For the evaluation of its disposition a specific HPLC assay with sensitive fluorescence detection was developed. Applying equilibrium dialysis, plasma protein binding of ivermectin was measured in five healthy individuals and it averaged 93.2±4.4\% (SD). Such strong binding should be taken into consideration, especially in patients with malnutrition or with diseases in which a decrease in plasma proteins and consequently a higher free fraction of ivermectin could be expected.

@article{klotz1990ivermectin, abstract = {Human pharmacokinetic data on the new antiparasitic agent, ivermectin, are scanty. For the evaluation of its disposition a specific HPLC assay with sensitive fluorescence detection was developed. Applying equilibrium dialysis, plasma protein binding of ivermectin was measured in five healthy individuals and it averaged 93.2{\textpm}4.4{\%} (SD). Such strong binding should be taken into consideration, especially in patients with malnutrition or with diseases in which a decrease in plasma proteins and consequently a higher free fraction of ivermectin could be expected.}, added-at = {2022-05-12T14:37:11.000+0200}, author = {Klotz, U. and Ogbuokiri, J. E. and Okonkwo, P. O.}, biburl = {https://www.bibsonomy.org/bibtex/2a15c36450637c9e764c42470dc33f8d3/fordham1}, day = 01, description = {Ivermectin binds avidly to plasma proteins | SpringerLink}, doi = {10.1007/BF00316107}, interhash = {a8d8a0215e550bf0041c1ff15a61b2ab}, intrahash = {a15c36450637c9e764c42470dc33f8d3}, issn = {1432-1041}, journal = {European Journal of Clinical Pharmacology}, keywords = {ivermectin plasma_proteins}, month = dec, number = 6, pages = {607--608}, timestamp = {2022-05-12T14:37:11.000+0200}, title = {Ivermectin binds avidly to plasma proteins}, url = {https://doi.org/10.1007/BF00316107}, volume = 39, year = 1990 }