%0 Journal Article %1 Vermeulen2001 %A Vermeulen, G. M. %A Bruinse, H. W. %A de Vries, L. S. %D 2001 %J Eur J Obstet Gynecol Reprod Biol %K Anti-Bacterial Agents; Brain Diseases; Cerebral Hemorrhage; Palsy; Female; Fetal Membranes, Premature Rupture; Gestational Age; Humans; Infant Mortality; Infant, Newborn; Premature; Infection; Leukomalacia, Periventricular; Logistic Models; Nervous System; Obstetric Labor, Odds Ratio; Pregnancy; Risk Factors %N 2 %P 207--212 %T Perinatal risk factors for adverse neurodevelopmental outcome after spontaneous preterm birth. %V 99 %X OBJECTIVE: The aim of this study was to investigate to what extend perinatal factors contribute to the neurodevelopmental outcome in a group neonates born after spontaneous preterm labour with or without prolonged rupture of the membranes (PROM). METHODS: In a cohort of neonates born after the spontaneous onset of labour with or without PROM before 34 weeks of gestation a stepwise forward logistic regression was performed to analyse the influence of antenatal and postnatal variables on adverse outcome. Adverse neurodevelopmental outcome was defined as a Griffith's developmental score <85, cerebral palsy, a major disability or perinatal death associated with severe cerebral damage. RESULTS: The study group consisted of 185 neonates. Seven neonates died with severe cerebral damage. After a forward logistic regression analysis three factors appeared to have an independent influence: gestational age protected against an adverse outcome (odds ratio (OR) per day increase 0.95, 95\% confidence interval (CI) 0.90-0.97) while abnormal cranial ultrasound (intraventricular haemorrhage and periventricular leucomalacia) (OR 6.33, 95\% CI 2.16-18.52) and the need for a second course of antibiotics (OR 1.85, 95\% CI 1.02-3.33) increased the risk for adverse outcome. Comparing the group with a normal neurodevelopmental outcome with those with cerebral palsy, cranial ultrasound abnormalities were independently associated with cerebral palsy (OR 48.75, 95\% CI 11.78-201.76). CONCLUSION: The most important way of preventing neurological damage in infants is to increase gestational age at birth and to avoid the development of intraventricular haemorrhage and periventricular leucomalacia.

@article{Vermeulen2001, abstract = {OBJECTIVE: The aim of this study was to investigate to what extend perinatal factors contribute to the neurodevelopmental outcome in a group neonates born after spontaneous preterm labour with or without prolonged rupture of the membranes (PROM). METHODS: In a cohort of neonates born after the spontaneous onset of labour with or without PROM before 34 weeks of gestation a stepwise forward logistic regression was performed to analyse the influence of antenatal and postnatal variables on adverse outcome. Adverse neurodevelopmental outcome was defined as a Griffith's developmental score <85, cerebral palsy, a major disability or perinatal death associated with severe cerebral damage. RESULTS: The study group consisted of 185 neonates. Seven neonates died with severe cerebral damage. After a forward logistic regression analysis three factors appeared to have an independent influence: gestational age protected against an adverse outcome (odds ratio (OR) per day increase 0.95, 95\% confidence interval (CI) 0.90-0.97) while abnormal cranial ultrasound (intraventricular haemorrhage and periventricular leucomalacia) (OR 6.33, 95\% CI 2.16-18.52) and the need for a second course of antibiotics (OR 1.85, 95\% CI 1.02-3.33) increased the risk for adverse outcome. Comparing the group with a normal neurodevelopmental outcome with those with cerebral palsy, cranial ultrasound abnormalities were independently associated with cerebral palsy (OR 48.75, 95\% CI 11.78-201.76). CONCLUSION: The most important way of preventing neurological damage in infants is to increase gestational age at birth and to avoid the development of intraventricular haemorrhage and periventricular leucomalacia.}, added-at = {2014-07-19T21:50:59.000+0200}, author = {Vermeulen, G. M. and Bruinse, H. W. and de Vries, L. S.}, biburl = {https://www.bibsonomy.org/bibtex/2b79349d0aa177c10918dc0311118b5b2/ar0berts}, groups = {public}, interhash = {61ec1b7d370649fb0f4372738cef732c}, intrahash = {b79349d0aa177c10918dc0311118b5b2}, journal = {Eur J Obstet Gynecol Reprod Biol}, keywords = {Anti-Bacterial Agents; Brain Diseases; Cerebral Hemorrhage; Palsy; Female; Fetal Membranes, Premature Rupture; Gestational Age; Humans; Infant Mortality; Infant, Newborn; Premature; Infection; Leukomalacia, Periventricular; Logistic Models; Nervous System; Obstetric Labor, Odds Ratio; Pregnancy; Risk Factors}, month = Dec, number = 2, pages = {207--212}, pii = {S0301211501003839}, pmid = {11788173}, timestamp = {2014-07-19T21:50:59.000+0200}, title = {Perinatal risk factors for adverse neurodevelopmental outcome after spontaneous preterm birth.}, username = {ar0berts}, volume = 99, year = 2001 }