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Structural Organization and Properties of DNA in the Cell

, , and . Abstract Book of the XXIII IUPAP International Conference on Statistical Physics, Genova, Italy, (9-13 July 2007)

Abstract

The dynamical architecture of the cell nucleus can be regarded as one of the grand challenges of structural biophysics. The genomic DNA and the histone proteins compacting it into chromatin account for the major part of the contents of the nucleus. We will discuss the structural properties of the DNA. We present a model for the chain that can successfully describe experimentally measured distance distributions on chromosome 1 and 11 in human cells using the notion of “ridge” regions (cluster of strongly expressed genes) and the “antiridge” regions.

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