Randomized controlled trials are the "gold standard" for estimating the causal effects of treatments. However, it is often not feasible to conduct such a trial because of ethical concerns or budgetary constraints. We expand upon an approach to the analysis of observational data sets that mimics a sequence of randomized studies by implementing propensity score models within each trial to achieve covariate balance, using weighting and matching. The methods are illustrated using data from a safety study of the relationship between second-generation antipsychotics and type 2 diabetes (outcome) in Medicaid-insured children aged 10-18 years across the United States from 2003 to 2007. Challenges in this data set include a rare outcome, a rare exposure, substantial and important differences between exposure groups, and a very large sample size.
%0 Journal Article
%1 Ross2015
%A Ross, Michelle E
%A Kreider, Amanda R
%A Huang, Yuan-Shung
%A Matone, Meredith
%A Rubin, David M
%A Localio, A Russell
%D 2015
%J American journal of epidemiology
%K confounding discrete-timefailureanalysis inverseprobabilityoftreatmentweighting marginaleffects observationalstudy propensityscorematching randomizedexperiments
%N 12
%P 989-95
%R 10.1093/aje/kwu469
%T Propensity Score Methods for Analyzing Observational Data Like Randomized Experiments: Challenges and Solutions for Rare Outcomes and Exposures.
%U http://www.ncbi.nlm.nih.gov/pubmed/25995287
%V 181
%X Randomized controlled trials are the "gold standard" for estimating the causal effects of treatments. However, it is often not feasible to conduct such a trial because of ethical concerns or budgetary constraints. We expand upon an approach to the analysis of observational data sets that mimics a sequence of randomized studies by implementing propensity score models within each trial to achieve covariate balance, using weighting and matching. The methods are illustrated using data from a safety study of the relationship between second-generation antipsychotics and type 2 diabetes (outcome) in Medicaid-insured children aged 10-18 years across the United States from 2003 to 2007. Challenges in this data set include a rare outcome, a rare exposure, substantial and important differences between exposure groups, and a very large sample size.
@article{Ross2015,
abstract = {Randomized controlled trials are the "gold standard" for estimating the causal effects of treatments. However, it is often not feasible to conduct such a trial because of ethical concerns or budgetary constraints. We expand upon an approach to the analysis of observational data sets that mimics a sequence of randomized studies by implementing propensity score models within each trial to achieve covariate balance, using weighting and matching. The methods are illustrated using data from a safety study of the relationship between second-generation antipsychotics and type 2 diabetes (outcome) in Medicaid-insured children aged 10-18 years across the United States from 2003 to 2007. Challenges in this data set include a rare outcome, a rare exposure, substantial and important differences between exposure groups, and a very large sample size.},
added-at = {2023-02-03T11:44:35.000+0100},
author = {Ross, Michelle E and Kreider, Amanda R and Huang, Yuan-Shung and Matone, Meredith and Rubin, David M and Localio, A Russell},
biburl = {https://www.bibsonomy.org/bibtex/2ca3c074d85ecf8f498aacf069e951688/jepcastel},
doi = {10.1093/aje/kwu469},
interhash = {5375e8ca37982b77c76e61754e67fea4},
intrahash = {ca3c074d85ecf8f498aacf069e951688},
issn = {1476-6256},
journal = {American journal of epidemiology},
keywords = {confounding discrete-timefailureanalysis inverseprobabilityoftreatmentweighting marginaleffects observationalstudy propensityscorematching randomizedexperiments},
month = {6},
note = {Propensity score},
number = 12,
pages = {989-95},
pmid = {25995287},
timestamp = {2023-02-03T11:44:35.000+0100},
title = {Propensity Score Methods for Analyzing Observational Data Like Randomized Experiments: Challenges and Solutions for Rare Outcomes and Exposures.},
url = {http://www.ncbi.nlm.nih.gov/pubmed/25995287},
volume = 181,
year = 2015
}