One of the most promising applications of the X-ray phase-contrast imaging is the three dimensional tomographic reconstruction of the index of refraction. However, results reported so far are limited to relatively small samples. We present here the tomographic reconstruction of the index of refraction distribution of a large biomedical sample (&\#x0003E; 10 cm diameter). A quantitative study comparing the absorption and phase contrast (analyzer-based) tomography images shows that the distribution of the index of refraction obtained with the phase contrast method provides a more accurate depiction (3&\#x02013;10 times larger signal to noise ratio values) of the sample internal structure. Thanks to the higher sensitivity of this method, the improved precision was obtained using an incoming photon fluence on the sample several times smaller than in the case of absorption imaging.
Description
Optics InfoBase: Biomedical Optics Express - On the possibility of quantitative refractive-index tomography of large biomedical samples with hard X-rays
%0 Journal Article
%1 Gasilov:13
%A Gasilov, Sergei
%A Mittone, Alberto
%A Brun, Emmanuel
%A Bravin, Alberto
%A Grandl, Susanne
%A Coan, Paola
%D 2013
%I OSA
%J Biomed. Opt. Express
%K biology imaging recostruction tomography x-rays
%N 9
%P 1512--1518
%R 10.1364/BOE.4.001512
%T On the possibility of quantitative refractive-index tomography of large biomedical samples with hard X-rays
%U http://www.opticsinfobase.org/boe/abstract.cfm?URI=boe-4-9-1512
%V 4
%X One of the most promising applications of the X-ray phase-contrast imaging is the three dimensional tomographic reconstruction of the index of refraction. However, results reported so far are limited to relatively small samples. We present here the tomographic reconstruction of the index of refraction distribution of a large biomedical sample (&\#x0003E; 10 cm diameter). A quantitative study comparing the absorption and phase contrast (analyzer-based) tomography images shows that the distribution of the index of refraction obtained with the phase contrast method provides a more accurate depiction (3&\#x02013;10 times larger signal to noise ratio values) of the sample internal structure. Thanks to the higher sensitivity of this method, the improved precision was obtained using an incoming photon fluence on the sample several times smaller than in the case of absorption imaging.
@article{Gasilov:13,
abstract = {One of the most promising applications of the X-ray phase-contrast imaging is the three dimensional tomographic reconstruction of the index of refraction. However, results reported so far are limited to relatively small samples. We present here the tomographic reconstruction of the index of refraction distribution of a large biomedical sample (\&\#x0003E; 10 cm diameter). A quantitative study comparing the absorption and phase contrast (analyzer-based) tomography images shows that the distribution of the index of refraction obtained with the phase contrast method provides a more accurate depiction (3\&\#x02013;10 times larger signal to noise ratio values) of the sample internal structure. Thanks to the higher sensitivity of this method, the improved precision was obtained using an incoming photon fluence on the sample several times smaller than in the case of absorption imaging.},
added-at = {2013-11-27T12:48:52.000+0100},
author = {Gasilov, Sergei and Mittone, Alberto and Brun, Emmanuel and Bravin, Alberto and Grandl, Susanne and Coan, Paola},
biburl = {https://www.bibsonomy.org/bibtex/2d247194458e86ff85c1ed947f976bc29/alex_ruff},
description = {Optics InfoBase: Biomedical Optics Express - On the possibility of quantitative refractive-index tomography of large biomedical samples with hard X-rays},
doi = {10.1364/BOE.4.001512},
interhash = {ec52c148bdf956e39391f17c943a8c5b},
intrahash = {d247194458e86ff85c1ed947f976bc29},
journal = {Biomed. Opt. Express},
keywords = {biology imaging recostruction tomography x-rays},
month = sep,
number = 9,
pages = {1512--1518},
publisher = {OSA},
timestamp = {2013-11-27T12:48:52.000+0100},
title = {On the possibility of quantitative refractive-index tomography of large biomedical samples with hard X-rays},
url = {http://www.opticsinfobase.org/boe/abstract.cfm?URI=boe-4-9-1512},
volume = 4,
year = 2013
}