Despite recent advances in preventing sudden cardiac death (SCD) due
to cardiac arrhythmia, its incidence in the population at large has
remained unacceptably high. Better understanding of the interaction
among various functional, structural, and genetic factors underlying
the susceptibility to, and initiation of, fatal arrhythmias is a
major goal and will provide new tools for the prediction, prevention,
and therapy of SCD. Here, we review the role of aberrant intracellular
Ca handling, ionic imbalances associated with acute myocardial ischemia,
neurohumoral changes, and genetic predisposition in the pathogenesis
of SCD due to cardiac arrhythmia. Therapeutic measures to prevent
SCD are also discussed.
%0 Journal Article
%1 Ruba_2005_2305
%A Rubart, Michael
%A Zipes, Douglas P
%D 2005
%J J. Clin. Invest.
%K 16138184 Action Arrhythmia, Calcium, Cardiac, Channels, Death, Disease, Electrocardiography, Extramural, Genetic Gov't, Humans, Ion Ischemia, Messenger Myocardial Myocardium, N.I.H., Non-U.S. P.H.S., Potentials, Predisposition Renin-Angiotensin Research Second Sudden, Support, System, Systems, U.S. to
%N 9
%P 2305--2315
%R 10.1172/JCI26381
%T Mechanisms of sudden cardiac death.
%U http://dx.doi.org/10.1172/JCI26381
%V 115
%X Despite recent advances in preventing sudden cardiac death (SCD) due
to cardiac arrhythmia, its incidence in the population at large has
remained unacceptably high. Better understanding of the interaction
among various functional, structural, and genetic factors underlying
the susceptibility to, and initiation of, fatal arrhythmias is a
major goal and will provide new tools for the prediction, prevention,
and therapy of SCD. Here, we review the role of aberrant intracellular
Ca handling, ionic imbalances associated with acute myocardial ischemia,
neurohumoral changes, and genetic predisposition in the pathogenesis
of SCD due to cardiac arrhythmia. Therapeutic measures to prevent
SCD are also discussed.
@article{Ruba_2005_2305,
abstract = {Despite recent advances in preventing sudden cardiac death (SCD) due
to cardiac arrhythmia, its incidence in the population at large has
remained unacceptably high. Better understanding of the interaction
among various functional, structural, and genetic factors underlying
the susceptibility to, and initiation of, fatal arrhythmias is a
major goal and will provide new tools for the prediction, prevention,
and therapy of SCD. Here, we review the role of aberrant intracellular
Ca handling, ionic imbalances associated with acute myocardial ischemia,
neurohumoral changes, and genetic predisposition in the pathogenesis
of SCD due to cardiac arrhythmia. Therapeutic measures to prevent
SCD are also discussed.},
added-at = {2009-06-03T11:20:58.000+0200},
author = {Rubart, Michael and Zipes, Douglas P},
biburl = {https://www.bibsonomy.org/bibtex/2f53823e3ee9d1f62f58e3baaf610b035/hake},
description = {The whole bibliography file I use.},
doi = {10.1172/JCI26381},
file = {Ruba_2005_2305.pdf:Ruba_2005_2305.pdf:PDF},
interhash = {a2174ee9a1226b6cbeedd07cd77e7599},
intrahash = {f53823e3ee9d1f62f58e3baaf610b035},
journal = {J. Clin. Invest.},
keywords = {16138184 Action Arrhythmia, Calcium, Cardiac, Channels, Death, Disease, Electrocardiography, Extramural, Genetic Gov't, Humans, Ion Ischemia, Messenger Myocardial Myocardium, N.I.H., Non-U.S. P.H.S., Potentials, Predisposition Renin-Angiotensin Research Second Sudden, Support, System, Systems, U.S. to},
month = Sep,
number = 9,
pages = {2305--2315},
pmid = {16138184},
timestamp = {2009-06-03T11:21:27.000+0200},
title = {Mechanisms of sudden cardiac death.},
url = {http://dx.doi.org/10.1172/JCI26381},
volume = 115,
year = 2005
}