AIM: To determine the neurodevelopmental morbidity in the surviving twin after fetal or infant death of the co-twin. METHODS: Twin pregnancies with an antepartum or infant death delivered between 1981 and 1992 were identified from the Northern Perinatal Mortality Survey. Information on the neurodevelopmental morbidity of infant survivors of a deceased co-twin was obtained by a questionnaire sent to the community paediatrician or general practitioner. RESULTS: A total of 111 children who survived infancy after the fetal death of the co-twin (group 1) and 142 from liveborn twin pairs in which one twin died in infancy (group 2) were traced. Responses were received from 97 (87\%) and 130 (92\%) respectively. In group 1, the cerebral palsy prevalence was 93 (95\% confidence interval (CI) 43 to 169) per 1000 infant survivors; it was more common in like-sex pairs (8/70) with a prevalence of 114 (95\% CI 51 to 213) compared with 45 (95\% CI 1 to 228) per 1000 infant survivors in unlike-sex pairs (1/22). The overall prevalence of neurodevelopmental morbidity (including developmental delay) was 175 (95\% CI 106 to 266) per 1000. In group 2, the cerebral palsy prevalence was 154 (95\% CI 84 to 223) per 1000 infant survivors in like-sex (16/104) and 77 (95\% CI 9 to 251) in unlike-sex (2/26) survivors; the overall prevalence of neurodevelopmental morbidity was 246 (95\% CI 172 to 320) per 1000. CONCLUSIONS: The risk of cerebral palsy is increased in the surviving twin after a fetal or infant co-twin death compared with the general twin population. Like-sex twins are at greater risk than unlike-sex. The probable cause, in addition to the consequences of prematurity, is twin-twin transfusion problems associated with monochorionicity.
%0 Journal Article
%1 Glinianaia2002
%A Glinianaia, S. V.
%A Pharoah, P. O D
%A Wright, C.
%A Rankin, J. M.
%A Group, Northern Region Perinatal Mortality Survey Steering
%D 2002
%J Arch Dis Child Fetal Neonatal Ed
%K Brain Diseases; Cause of Death; Cerebral Palsy; Diseases in Twins; England; Female; Fetal Fetofetal Transfusion; Follow-Up Studies; Gestational Age; Humans; Infant Mortality; Infant, Newborn; Male; Pregnancy; Prevalence; Risk Factors; Sex Factors
%N 1
%P F9--15
%T Fetal or infant death in twin pregnancy: neurodevelopmental consequence for the survivor.
%V 86
%X AIM: To determine the neurodevelopmental morbidity in the surviving twin after fetal or infant death of the co-twin. METHODS: Twin pregnancies with an antepartum or infant death delivered between 1981 and 1992 were identified from the Northern Perinatal Mortality Survey. Information on the neurodevelopmental morbidity of infant survivors of a deceased co-twin was obtained by a questionnaire sent to the community paediatrician or general practitioner. RESULTS: A total of 111 children who survived infancy after the fetal death of the co-twin (group 1) and 142 from liveborn twin pairs in which one twin died in infancy (group 2) were traced. Responses were received from 97 (87\%) and 130 (92\%) respectively. In group 1, the cerebral palsy prevalence was 93 (95\% confidence interval (CI) 43 to 169) per 1000 infant survivors; it was more common in like-sex pairs (8/70) with a prevalence of 114 (95\% CI 51 to 213) compared with 45 (95\% CI 1 to 228) per 1000 infant survivors in unlike-sex pairs (1/22). The overall prevalence of neurodevelopmental morbidity (including developmental delay) was 175 (95\% CI 106 to 266) per 1000. In group 2, the cerebral palsy prevalence was 154 (95\% CI 84 to 223) per 1000 infant survivors in like-sex (16/104) and 77 (95\% CI 9 to 251) in unlike-sex (2/26) survivors; the overall prevalence of neurodevelopmental morbidity was 246 (95\% CI 172 to 320) per 1000. CONCLUSIONS: The risk of cerebral palsy is increased in the surviving twin after a fetal or infant co-twin death compared with the general twin population. Like-sex twins are at greater risk than unlike-sex. The probable cause, in addition to the consequences of prematurity, is twin-twin transfusion problems associated with monochorionicity.
@article{Glinianaia2002,
abstract = {AIM: To determine the neurodevelopmental morbidity in the surviving twin after fetal or infant death of the co-twin. METHODS: Twin pregnancies with an antepartum or infant death delivered between 1981 and 1992 were identified from the Northern Perinatal Mortality Survey. Information on the neurodevelopmental morbidity of infant survivors of a deceased co-twin was obtained by a questionnaire sent to the community paediatrician or general practitioner. RESULTS: A total of 111 children who survived infancy after the fetal death of the co-twin (group 1) and 142 from liveborn twin pairs in which one twin died in infancy (group 2) were traced. Responses were received from 97 (87\%) and 130 (92\%) respectively. In group 1, the cerebral palsy prevalence was 93 (95\% confidence interval (CI) 43 to 169) per 1000 infant survivors; it was more common in like-sex pairs (8/70) with a prevalence of 114 (95\% CI 51 to 213) compared with 45 (95\% CI 1 to 228) per 1000 infant survivors in unlike-sex pairs (1/22). The overall prevalence of neurodevelopmental morbidity (including developmental delay) was 175 (95\% CI 106 to 266) per 1000. In group 2, the cerebral palsy prevalence was 154 (95\% CI 84 to 223) per 1000 infant survivors in like-sex (16/104) and 77 (95\% CI 9 to 251) in unlike-sex (2/26) survivors; the overall prevalence of neurodevelopmental morbidity was 246 (95\% CI 172 to 320) per 1000. CONCLUSIONS: The risk of cerebral palsy is increased in the surviving twin after a fetal or infant co-twin death compared with the general twin population. Like-sex twins are at greater risk than unlike-sex. The probable cause, in addition to the consequences of prematurity, is twin-twin transfusion problems associated with monochorionicity.},
added-at = {2014-07-19T19:33:20.000+0200},
author = {Glinianaia, S. V. and Pharoah, P. O D and Wright, C. and Rankin, J. M. and Group, Northern Region Perinatal Mortality Survey Steering},
biburl = {https://www.bibsonomy.org/bibtex/2f670f43faaf59096428c41cf8d53e532/ar0berts},
groups = {public},
interhash = {c549fb9a15404069e3e70b67b76efdb7},
intrahash = {f670f43faaf59096428c41cf8d53e532},
journal = {Arch Dis Child Fetal Neonatal Ed},
keywords = {Brain Diseases; Cause of Death; Cerebral Palsy; Diseases in Twins; England; Female; Fetal Fetofetal Transfusion; Follow-Up Studies; Gestational Age; Humans; Infant Mortality; Infant, Newborn; Male; Pregnancy; Prevalence; Risk Factors; Sex Factors},
month = Jan,
number = 1,
pages = {F9--15},
pmid = {11815541},
timestamp = {2014-07-19T19:33:20.000+0200},
title = {Fetal or infant death in twin pregnancy: neurodevelopmental consequence for the survivor.},
username = {ar0berts},
volume = 86,
year = 2002
}