%0 Journal Article %1 Albright2001 %A Albright, A. L. %A Barry, M. J. %A Shafton, D. H. %A Ferson, S. S. %D 2001 %J Dev Med Child Neurol %K Adolescent; Adult; Baclofen; Cerebral Palsy; Child; Child, Preschool; Dystonia; Female; Follow-Up Studies; Humans; Infusion Pumps, Implantable; Infusions, Parenteral; Injections, Spinal; Male; Muscle Relaxants, Central; Spasticity; Quality of Life; Severity Illness Index; Treatment Outcome %N 10 %P 652--657 %T Intrathecal baclofen for generalized dystonia. %V 43 %X The aim of this study was to evaluate the effects of intrathecal bacolfen (ITB) on patients with severe generalized dystonia. Eighty-six participants ranging in age from 3 to 42 years (median age 13 years) with generalized dystonia refractory to oral medications were offered treatment with ITB. Dystonia was associated with cerebral palsy in 71\% of participants. Response to ITB was tested by continuous infusions in 72\%, and by bolus injections in 17\% of participants who had both dystonia and spasticity. Ninety-one percent of participants responded to the screening infusion and 93\% to the bolus injections. Pumps were implanted in 77 participants. Dystonia scores at 3, 6, 12, and 24 months were significantly decreased (p<0.005) compared with baseline scores. Dystonia scores were significantly lower in those with intrathecal catheters positioned at T4, or higher than in those with catheters at T6 or lower (p=0.005). Ninety-two percent of participants implanted with a pump retained their responses to ITB during a median follow-up of 29 months. Patient questionnaires indicated that quality of life and ease of care improved in 86\% and speech improved in 33\%. Side effects of ITB occurred in 26\% of participants. Surgical complications occurred in 38\% and included CSF leaks, infections, and catheter problems. ITB is probably the treatment of choice for generalized dystonia if oral medications are ineffective.

@article{Albright2001, abstract = {The aim of this study was to evaluate the effects of intrathecal bacolfen (ITB) on patients with severe generalized dystonia. Eighty-six participants ranging in age from 3 to 42 years (median age 13 years) with generalized dystonia refractory to oral medications were offered treatment with ITB. Dystonia was associated with cerebral palsy in 71\% of participants. Response to ITB was tested by continuous infusions in 72\%, and by bolus injections in 17\% of participants who had both dystonia and spasticity. Ninety-one percent of participants responded to the screening infusion and 93\% to the bolus injections. Pumps were implanted in 77 participants. Dystonia scores at 3, 6, 12, and 24 months were significantly decreased (p<0.005) compared with baseline scores. Dystonia scores were significantly lower in those with intrathecal catheters positioned at T4, or higher than in those with catheters at T6 or lower (p=0.005). Ninety-two percent of participants implanted with a pump retained their responses to ITB during a median follow-up of 29 months. Patient questionnaires indicated that quality of life and ease of care improved in 86\% and speech improved in 33\%. Side effects of ITB occurred in 26\% of participants. Surgical complications occurred in 38\% and included CSF leaks, infections, and catheter problems. ITB is probably the treatment of choice for generalized dystonia if oral medications are ineffective.}, added-at = {2014-07-19T17:38:04.000+0200}, author = {Albright, A. L. and Barry, M. J. and Shafton, D. H. and Ferson, S. S.}, biburl = {https://www.bibsonomy.org/bibtex/2702437e73723fe3c7ecc4906d79c929b/ar0berts}, groups = {public}, interhash = {3712bac5ccdb4b3aa5f9b8a146e50297}, intrahash = {702437e73723fe3c7ecc4906d79c929b}, journal = {Dev Med Child Neurol}, keywords = {Adolescent; Adult; Baclofen; Cerebral Palsy; Child; Child, Preschool; Dystonia; Female; Follow-Up Studies; Humans; Infusion Pumps, Implantable; Infusions, Parenteral; Injections, Spinal; Male; Muscle Relaxants, Central; Spasticity; Quality of Life; Severity Illness Index; Treatment Outcome}, month = Oct, number = 10, pages = {652--657}, pmid = {11665821}, timestamp = {2014-07-19T17:38:04.000+0200}, title = {Intrathecal baclofen for generalized dystonia.}, username = {ar0berts}, volume = 43, year = 2001 }