Abstract
This paper demonstrates that it is possible to use
genetic programming to automatically create (reverse
engineer) a computer program representing the logic
underlying the genetic network for the expression level
of the lac operon (composed of the Z, Y, and A genes)
as measured by its mRNA. Genetic programming starts
with observed time-domain expression levels of two
genes (REPRESSOR or CAP) and the concentrations of two
substances (GLUCOSE or LACTOSE) and automatically
creates both a topological arrangement of conditional
and comparative functions as well as all necessary
numerical parameters of a genetic network whose
behavior matches observed time-domain data.
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