%0 Journal Article %1 WOS:000246008300044 %A Pereira, B G %A Vianna-Soares, C D %A Righi, A %A Pinheiro, M V B %A Flores, M Z S %A Bezerra, E M %A Freire, V N %A Lemos, V %A Caetano, E W S %A Cavada, B S %C PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS %D 2007 %I ELSEVIER SCIENCE BV %J JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS %K 3-oxathiolanyl)]cytosine} Raman `(1, `-hydroximetiol-5 cis-1{[}2 conformers; density functional human immunodeficiency modes; spectrum; theory; vibrational virus; {lamivudine; %N 5 %P 1885-1889 %R 10.1016/j.jpba.2007.01.014 %T Identification of lamivudine conformers by Raman scattering measurements and quantum chemical calculations %V 43 %X Characterization of nucleoside and non-nucleoside human immunodeficiency virus (HIV) reverse transcriptase inhibitors conformers, NRTIs and NNRTIs, respectively, is fundamental for an improved treatment of infected individuals. Three conformers in lamivudine I powder are quickly identified in this work by assignment of some Raman peaks to their vibrational frequencies, as obtained by first principles quantum chemical calculations. The method is proposed as a practical procedure for non-destructive identification, analysis, and process monitoring of NRTIs and NNRTIs conformers. (c) 2007 Elsevier B.V. All rights reserved.

@article{WOS:000246008300044, abstract = {Characterization of nucleoside and non-nucleoside human immunodeficiency virus (HIV) reverse transcriptase inhibitors conformers, NRTIs and NNRTIs, respectively, is fundamental for an improved treatment of infected individuals. Three conformers in lamivudine I powder are quickly identified in this work by assignment of some Raman peaks to their vibrational frequencies, as obtained by first principles quantum chemical calculations. The method is proposed as a practical procedure for non-destructive identification, analysis, and process monitoring of NRTIs and NNRTIs conformers. (c) 2007 Elsevier B.V. All rights reserved.}, added-at = {2022-05-23T20:00:14.000+0200}, address = {PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS}, author = {Pereira, B G and Vianna-Soares, C D and Righi, A and Pinheiro, M V B and Flores, M Z S and Bezerra, E M and Freire, V N and Lemos, V and Caetano, E W S and Cavada, B S}, biburl = {https://www.bibsonomy.org/bibtex/2efc3c86b275a82e02f38b1d1ef9f7a12/ppgfis_ufc_br}, doi = {10.1016/j.jpba.2007.01.014}, interhash = {569b23a4000563970bf1e992838cd94e}, intrahash = {efc3c86b275a82e02f38b1d1ef9f7a12}, issn = {0731-7085}, journal = {JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS}, keywords = {3-oxathiolanyl)]cytosine} Raman `(1, `-hydroximetiol-5 cis-1{[}2 conformers; density functional human immunodeficiency modes; spectrum; theory; vibrational virus; {lamivudine;}, number = 5, pages = {1885-1889}, publisher = {ELSEVIER SCIENCE BV}, pubstate = {published}, timestamp = {2022-05-23T20:00:14.000+0200}, title = {Identification of lamivudine conformers by Raman scattering measurements and quantum chemical calculations}, tppubtype = {article}, volume = 43, year = 2007 }