%0 Journal Article %1 hedrich2023vacuole %A Hedrich, R. %A Muller, T. D. %A Marten, I. %A Becker, D. %D 2023 %J Trends Plant Sci %K *Arabidopsis/metabolism myOwn %N 6 %P 673-684 %R 10.1016/j.tplants.2023.01.001 %T TPC1 vacuole SV channel gains further shape - voltage priming of calcium-dependent gating %U https://www.ncbi.nlm.nih.gov/pubmed/36740491 %V 28 %X Across phyla, voltage-gated ion channels (VGICs) allow excitability. The vacuolar two-pore channel AtTPC1 from the tiny mustard plant Arabidopsis thaliana has emerged as a paradigm for deciphering the role of voltage and calcium signals in membrane excitation. Among the numerous experimentally determined structures of VGICs, AtTPC1 was the first to be revealed in a closed and resting state, fueling speculation about structural rearrangements during channel activation. Two independent reports on the structure of a partially opened AtTPC1 channel protein have led to working models that offer promising insights into the molecular switches associated with the gating process. We review new structure-function models and also discuss the evolutionary impact of two-pore channels (TPCs) on K(+) homeostasis and vacuolar excitability.

@article{hedrich2023vacuole, abstract = {Across phyla, voltage-gated ion channels (VGICs) allow excitability. The vacuolar two-pore channel AtTPC1 from the tiny mustard plant Arabidopsis thaliana has emerged as a paradigm for deciphering the role of voltage and calcium signals in membrane excitation. Among the numerous experimentally determined structures of VGICs, AtTPC1 was the first to be revealed in a closed and resting state, fueling speculation about structural rearrangements during channel activation. Two independent reports on the structure of a partially opened AtTPC1 channel protein have led to working models that offer promising insights into the molecular switches associated with the gating process. We review new structure-function models and also discuss the evolutionary impact of two-pore channels (TPCs) on K(+) homeostasis and vacuolar excitability.}, added-at = {2024-02-15T15:08:22.000+0100}, author = {Hedrich, R. and Muller, T. D. and Marten, I. and Becker, D.}, biburl = {https://www.bibsonomy.org/bibtex/26d28a8422496658882419b0a1277061c/jvsi_all}, doi = {10.1016/j.tplants.2023.01.001}, interhash = {702c4a06f73d412caa9cbe1d0bf7d1fa}, intrahash = {6d28a8422496658882419b0a1277061c}, issn = {1878-4372 (Electronic) 1360-1385 (Linking)}, journal = {Trends Plant Sci}, keywords = {*Arabidopsis/metabolism myOwn}, note = {Hedrich, Rainer Muller, Thomas D Marten, Irene Becker, Dirk eng Research Support, Non-U.S. Gov't Review England 2023/02/06 Trends Plant Sci. 2023 Jun;28(6):673-684. doi: 10.1016/j.tplants.2023.01.001. Epub 2023 Feb 4.}, number = 6, pages = {673-684}, timestamp = {2024-02-15T15:08:22.000+0100}, title = {TPC1 vacuole SV channel gains further shape - voltage priming of calcium-dependent gating}, type = {Journal Article}, url = {https://www.ncbi.nlm.nih.gov/pubmed/36740491}, volume = 28, year = 2023 }