%0 Journal Article %1 haldane1931mathematical %A Haldane, J. B. S. %B Mathematical Proceedings of the Cambridge Philosophical Society %D 1931 %I Cambridge University Press %K epsistasis incompatibilities population_genetics speciation theory %N 1 %P 137-142-- %R DOI: 10.1017/S0305004100009439 %T A Mathematical Theory of Natural Selection. Part VIII. Metastable Populations %U https://www.cambridge.org/core/article/mathematical-theory-of-natural-selection-part-viii-metastable-populations/514790954D335CB1E6CBD0D82510A34D %V 27 %X Almost every species is, to a first approximation, in genetic equilibrium; that is to say no very drastic changes are occurring rapidly in its composition. It is a necessary condition for equilibrium that all new genes which arise at all frequently by mutation should be disadvantageous, otherwise they will spread through the population. Now each of two or more genes may be disadvantageous, but all together may be advantageous. An example of such balance has been given by Gonsalez(1). He found that, in purple-eyed Drosophila melanogaster, arc wing or axillary speck (each due to a recessive gene) shortened life, but the two together lengthened it.

@article{haldane1931mathematical, abstract = {Almost every species is, to a first approximation, in genetic equilibrium; that is to say no very drastic changes are occurring rapidly in its composition. It is a necessary condition for equilibrium that all new genes which arise at all frequently by mutation should be disadvantageous, otherwise they will spread through the population. Now each of two or more genes may be disadvantageous, but all together may be advantageous. An example of such balance has been given by Gonsalez(1). He found that, in purple-eyed Drosophila melanogaster, arc wing or axillary speck (each due to a recessive gene) shortened life, but the two together lengthened it.}, added-at = {2018-01-19T23:14:18.000+0100}, author = {Haldane, J. B. S.}, biburl = {https://www.bibsonomy.org/bibtex/273f1c623e60958dd3f28ac795879e743/peter.ralph}, booktitle = {Mathematical Proceedings of the Cambridge Philosophical Society}, doi = {DOI: 10.1017/S0305004100009439}, interhash = {7a9fb78d49edbb41cf0382a647cfdff3}, intrahash = {73f1c623e60958dd3f28ac795879e743}, issn = {03050041}, keywords = {epsistasis incompatibilities population_genetics speciation theory}, number = 1, pages = {137-142--}, publisher = {Cambridge University Press}, timestamp = {2018-01-19T23:14:18.000+0100}, title = {A Mathematical Theory of Natural Selection. {Part} {VIII}. {Metastable} Populations}, url = {https://www.cambridge.org/core/article/mathematical-theory-of-natural-selection-part-viii-metastable-populations/514790954D335CB1E6CBD0D82510A34D}, volume = 27, year = 1931 }