%0 Journal Article %1 noauthororeditor %A Khamroevna, Asadova Nigora %D 2021 %J International Journal of Trend in Scientific Research and Development %K Atrophy Gassal Lymphocytes T-cells Thymic ThymicHyperplasia cells changes cords environment epithelial experiment external factors histopathological morphology pain stress thymus %N 2 %P 78-81 %T Morphofunctional Changes in the Thymus Gland under the Influence of Psychogenic Factors %U https://www.ijtsrd.com/medicine/other/38735/morphofunctional-changes-in-the-thymus-gland-under-the-influence-of-psychogenic-factors/asadova-nigora-khamroevna %V 5 %X In the thymus of animals subjected to acute stress a decrease in lymphoid tissue was found accompanied by the death of lymphocytes in the cortex and medulla. Acute stress leads to the appearance in the thymus of a large number of degranulating mast cells and actively functioning epithelial tubules.Psychological stress has great impacts on the immune system particularly the leukocytes distribution. Although the impacts of acute stress on blood leukocytes distribution are well studied however it remains unclear how chronic stress affects leukocytes distribution in peripheral circulation. Furthermore there is no report about the role of spleen in the blood leukocytes distribution induced by stress. Here we show that spleen contributes to the alteration of restraint stress induced blood leukocytes distribution. Our data confirmed that restraint stress induced anxiety like behavior in mice. Furthermore we found that restraint stress decreased the CD4 CD8 ratio and elevated the percentages of natural killer cells monocytes and polymorphonuclear myeloid derived suppressor cell. We demonstrated that activation of hypothalamic pituitary adrenal axis HPA and sympathetic nervous system SNS contributes to restraint stress induced alteration of blood leukocyte distribution. Interestingly we found that splenectomy could reverse the change of CD4 CD8 ratio induced by restraint stress. Together our findings suggest that activation of HPA axis and SNS was responsible for the blood leukocyte subsets changes induced by restraint stress. Spleen at least in part contributed to the alteration in peripheral circulation induced by restraint stress. Asadova Nigora Khamroevna "Morphofunctional Changes in the Thymus Gland under the Influence of Psychogenic Factors" Published in International Journal of Trend in Scientific Research and Development (ijtsrd) ISSN: 2456-6470 Special Issue | International Research Development and Scientific Excellence in Academic Life March 2021 URL: https://www.ijtsrd.com/papers/ijtsrd38735.pdf Paper Url: https://www.ijtsrd.com/medicine/other/38735/morphofunctional-changes-in-the-thymus-gland-under-the-influence-of-psychogenic-factors/asadova-nigora-khamroevna

@article{noauthororeditor, abstract = {In the thymus of animals subjected to acute stress a decrease in lymphoid tissue was found accompanied by the death of lymphocytes in the cortex and medulla. Acute stress leads to the appearance in the thymus of a large number of degranulating mast cells and actively functioning epithelial tubules.Psychological stress has great impacts on the immune system particularly the leukocytes distribution. Although the impacts of acute stress on blood leukocytes distribution are well studied however it remains unclear how chronic stress affects leukocytes distribution in peripheral circulation. Furthermore there is no report about the role of spleen in the blood leukocytes distribution induced by stress. Here we show that spleen contributes to the alteration of restraint stress induced blood leukocytes distribution. Our data confirmed that restraint stress induced anxiety like behavior in mice. Furthermore we found that restraint stress decreased the CD4 CD8 ratio and elevated the percentages of natural killer cells monocytes and polymorphonuclear myeloid derived suppressor cell. We demonstrated that activation of hypothalamic pituitary adrenal axis HPA and sympathetic nervous system SNS contributes to restraint stress induced alteration of blood leukocyte distribution. Interestingly we found that splenectomy could reverse the change of CD4 CD8 ratio induced by restraint stress. Together our findings suggest that activation of HPA axis and SNS was responsible for the blood leukocyte subsets changes induced by restraint stress. Spleen at least in part contributed to the alteration in peripheral circulation induced by restraint stress. Asadova Nigora Khamroevna "Morphofunctional Changes in the Thymus Gland under the Influence of Psychogenic Factors" Published in International Journal of Trend in Scientific Research and Development (ijtsrd) ISSN: 2456-6470 Special Issue | International Research Development and Scientific Excellence in Academic Life March 2021 URL: https://www.ijtsrd.com/papers/ijtsrd38735.pdf Paper Url: https://www.ijtsrd.com/medicine/other/38735/morphofunctional-changes-in-the-thymus-gland-under-the-influence-of-psychogenic-factors/asadova-nigora-khamroevna }, added-at = {2021-05-06T12:16:52.000+0200}, author = {Khamroevna, Asadova Nigora}, biburl = {https://www.bibsonomy.org/bibtex/2fa3d3c2482214917b40bda00c2c2ae3e/ijtsrd}, interhash = {a86d7fa6a690ae46311bdb9075cb224d}, intrahash = {fa3d3c2482214917b40bda00c2c2ae3e}, issn = {2456-6470}, journal = {International Journal of Trend in Scientific Research and Development}, keywords = {Atrophy Gassal Lymphocytes T-cells Thymic ThymicHyperplasia cells changes cords environment epithelial experiment external factors histopathological morphology pain stress thymus}, language = {English}, month = mar, number = 2, pages = {78-81}, timestamp = {2021-05-06T12:16:52.000+0200}, title = {Morphofunctional Changes in the Thymus Gland under the Influence of Psychogenic Factors }, url = {https://www.ijtsrd.com/medicine/other/38735/morphofunctional-changes-in-the-thymus-gland-under-the-influence-of-psychogenic-factors/asadova-nigora-khamroevna}, volume = 5, year = 2021 }