%0 Book Section %1 statphys23_0492 %A Klein, A.M. %A Clayton, E. %A Doupé, D.P. %A Jones, P.H. %A Simons, B.D. %B Abstract Book of the XXIII IUPAP International Conference on Statistical Physics %C Genova, Italy %D 2007 %E Pietronero, Luciano %E Loreto, Vittorio %E Zapperi, Stefano %K cell kinetics nonequilibrium processes statphys23 topic-10 %T The fate of cells in skin: from clonal analysis to cell kinetics %U http://st23.statphys23.org/webservices/abstract/preview_pop.php?ID_PAPER=492 %X The rules governing cell division and differentiation are central to understanding the mechanisms of development, aging and cancer. However, since it is not possible to track the fate of cells individually, resolving these rules in vivo is a challenging enterprise. By utilising inducible genetic labelling, recent studies have shown that families of cells (clones) can be tracked in transgenic mouse epidermis in vivo. Drawing on these results, we describe how clonal fate data may be used to infer the laws of cell division and access the mechanism of murine epidermal homeostasis 1. \\ 1) Nature 446, 185-189 (2007)

@incollection{statphys23_0492, abstract = {The rules governing cell division and differentiation are central to understanding the mechanisms of development, aging and cancer. However, since it is not possible to track the fate of cells individually, resolving these rules \emph{in vivo} is a challenging enterprise. By utilising inducible genetic labelling, recent studies have shown that families of cells (clones) can be tracked in transgenic mouse epidermis \emph{in vivo}. Drawing on these results, we describe how clonal fate data may be used to infer the laws of cell division and access the mechanism of murine epidermal homeostasis [1]. \\ 1) Nature {\bf 446}, 185-189 (2007)}, added-at = {2007-06-20T10:16:09.000+0200}, address = {Genova, Italy}, author = {Klein, A.M. and Clayton, E. and Doup\'e, D.P. and Jones, P.H. and Simons, B.D.}, biburl = {https://www.bibsonomy.org/bibtex/231ff415d35e84564d5b2ee9f3a09f99b/statphys23}, booktitle = {Abstract Book of the XXIII IUPAP International Conference on Statistical Physics}, editor = {Pietronero, Luciano and Loreto, Vittorio and Zapperi, Stefano}, interhash = {d78079d72e485be0fa18e09447a5b9b3}, intrahash = {31ff415d35e84564d5b2ee9f3a09f99b}, keywords = {cell kinetics nonequilibrium processes statphys23 topic-10}, month = {9-13 July}, timestamp = {2007-06-20T10:16:21.000+0200}, title = {The fate of cells in skin: from clonal analysis to cell kinetics}, url = {http://st23.statphys23.org/webservices/abstract/preview_pop.php?ID_PAPER=492}, year = 2007 }