PyFacebook is currently best-tested with Django, and if you are just starting out with Python web development, the author highly recommends this combination :-). If you'd rather use another framework, there are also Pylons and other WSGI helpers in PyFacebook as well.
One thing I really love with the Python programming language is its incredible extensibility. Here’s a list of 50 awesome modules for Python, covering almost all needs: Databases, GUIs, Images, Sound, OS interaction, Web, and more.