Several studies have investigated whether in utero exposure to selective serotonin reuptake inhibitors (SSRIs) is associated with increased risk of developing mental‐ or behavioral disorders. The aim of this study was to perform a systematic review and meta‐analysis based on this literature.. To read the full article, log in using your NHS Athens details. To access full-text: click “Log in/Register” (top right hand side). Click ‘Institutional Login’ then select 'OpenAthens Federation', then ‘NHS England’. Enter your Athens details to view the article.
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Children of mothers with severe mental illness are at significantly increased risk of developing intellectual disability. Obstetric complications are also implicated in the risk for intellectual disability. Moreover, children of mothers with severe mental illness are more likely to be exposed to obstetric complications. The purpose of this study was to examine the independent and joint contributions of familial severe mental illness and obstetric complications to the risk of intellectual disability.. Login at top right hand side of page using your MPFT NHS OpenAthens for full text.
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Maternal autoantibodies to neuronal proteins may be one cause of neurodevelopmental disorders. This exploratory study used the Danish archived midgestational sera and their nationwide registers to search for antibodies to the N-methyl-D-aspartate receptor (NMDAR) and contactin-associated protein-like 2 (CASPR2) in maternal sera, and to relate them to subsequent psychiatric diagnoses in the woman or her child. To read the full article, log in using your NHS OpenAthens details.
In their JNNP manuscript, in this issue, Coutinho and colleagues identify an association between maternal autoantibodies against CASPR2 and an increased risk of neurodevelopmental disorders in offspring.1 The study by Coutinho and colleagues used a remarkable Danish resource of stored serum obtained from mothers during the first half of pregnancy, examined the sera for cell surface autoantibodies and correlated these findings with postpartum psychosis in the mother and neurodevelopmental outcomes in the offspring. Although the study failed to find an association of autoantibodies with subsequent maternal psychosis, there was an association between CASPR2 autoantibodies and neurodevelopmental disorders, although not with autistic spectrum disorder (ASD).1 Although two cohorts had to be combined to generate statistical significance for their main finding, the study by Coutinho and colleagues adds to an ever-increasing body of work that contributes to the hypothesis that the immune status of the mother has effects on the fetal brain.2To read the full article, log in using your NHS OpenAthens details.
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Maternal autoantibodies to neuronal proteins may be one cause of neurodevelopmental disorders. This exploratory study used the Danish archived midgestational sera and their nationwide registers to search for antibodies to the N-methyl-D-aspartate receptor (NMDAR) and contactin-associated protein-like 2 (CASPR2) in maternal sera, and to relate them to subsequent psychiatric diagnoses in the woman or her child including intellectual disabilities.....To read the full article, log in using your NHS OpenAthens details.
Perinatal mental disorders are important contributors to maternal morbidity and mortality globally,1–3 and are associated with adverse infant and child outcomes.4 There is clear evidence-based guidance on the detection and treatment of perinatal mental disorders in the general population,5 ,6 but little evidence on vulnerable subgroups who may have distinct clinical presentation and/or service needs. In the two selected studies, population-based regional Canadian data are used to investigate perinatal mental health among migrant women (focusing on their postnatal use of mental health services compared with non-migrant women),7 and among women with intellectual or developmental disabilities (IDD) (focusing on adverse maternal and neonatal outcomes among women with comorbid IDD and mental illness compared with women with IDD only).8 To read the full article, log in using your NHS OpenAthens details.
Perinatal mental disorders are important contributors to maternal morbidity and mortality globally,1–3 and are associated with adverse infant and child outcomes.4 There is clear evidence-based guidance on the detection and treatment of perinatal mental disorders in the general population,5 ,6 but little evidence on vulnerable subgroups who may have distinct clinical presentation and/or service needs. In the two selected studies, population-based regional Canadian data are used to investigate perinatal mental health among migrant women (focusing on their postnatal use of mental health services compared with non-migrant women),7 and among women with intellectual or developmental disabilities (IDD) (focusing on adverse maternal and neonatal outcomes among women with comorbid IDD and mental illness compared with women with IDD only).8...To read the full article, log in using your NHS OpenAthens details.
Background More women with learning disability (LD) are becoming mothers. Women with LD have rights to equal access to maternity care that meets their needs, however, many have poor pregnancy and birth outcomes compared to other women in the UK. Research is limited in this area.
Objectives The aim of the study was to explore the lived experiences of pregnancy, childbirth, prenatal and postnatal care and services received by this group of women in the UK, including their expressed information and support needs relating to maternity care. Open Access Article
Canadian Journal of Psychiatry61.11 (Nov 2016): 714-723.
Women with intellectual and developmental disabilities (IDD) have high rates of adverse perinatal outcomes. However, the perinatal health of women with co-occurring IDD and mental illness (dual diagnosis) is largely unknown. Our objectives were to 1) describe a cohort of women with dual diagnosis in terms of their social and health characteristics and 2) compare their risks for adverse maternal and neonatal outcomes to those of women with IDD only. To read the full article, log in using your NHS OpenAthens details.