Rheumatoid arthritis (RA) is a systemic autoimmune polyarticular disease. Despite being commonly affected in RA, the ankle and foot do not receive much attention, particularly in early disease. The precise diagnosis of their involvement and its impact on health is a clinical challenge that requires accurate assessment. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
Objectives The aorta inhibits paravertebral ossification in diffuse idiopathic skeletal hyperostosis. We investigated if syndesmophytes in ankylosing spondylitis (AS) occurred less often at the vertebral rim near the aorta. To read the full article, log in using your NHS OpenAthens details.
The COVID-19 pandemic led to rapid and widespread adoption of telemedicine in rheumatology care. The Asia Pacific League of Associations for Rheumatology (APLAR) working group was tasked with developing evidence-based recommendations for rheumatology practice to guide maintenance of the highest possible standards of clinical care and to enable broad patient reach. To read the full article, log in using your NHS OpenAthens details.
This commentary discusses the Cochrane Review 'Adjunctive therapies in addition to land-based exercise therapy for osteoarthritis of the hip or knee', published by the Cochrane Musculoskeletal Group. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
The aim of this study was to assess the safety and efficacy of Janus kinase inhibitors (JAKi), in the management of key clinical domains of PsA including peripheral arthritis, psoriasis, enthesitis and dactylitis. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
The aim of this commentary is to discuss from a rehabilitation perspective the Cochrane Review “Non-steroidal anti-inflammatory drugs for acute gout” by van Durme et al,
published by Cochrane Musculoskeletal Group. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
For patients with connective tissue disease-associated interstitial lung disease (CTD-ILD), early medical intervention would be desirable. This study analyzed the real-world, single-center use of nintedanib for CTD-ILD patients. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
Chronic pain can have significant physical, psychological and social effects on a person’s life, as well as on their families and friends. However, it is often not well-recognised or understood, which can lead to further harm. To read the full article, log in using your MPFT NHS OpenAthens details.
This study evaluated the influence of sarcopenia, especially muscle quality, on outcomes of antineutrophil cytoplasmic antibody-associated vasculitis (AAV). To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
To identify, critically evaluate and synthesize the evidence obtained from systematic reviews on the association between genetic polymorphisms and osteoarthritis (OA) development. To read the full article, choose “Institutional Login” and search for “Midlands Partnership”.
Old age and glucocorticoid (GC) use increase the susceptibility to infection in patients with rheumatoid arthritis (RA). Accordingly, we investigated whether GC discontinuation reduces the incidence of infection in older adults with RA and analyzed factors associated with GC discontinuation. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
This ancillary study of the MAINRITSAN 2 trial aimed to explore the relationship between rituximab plasma concentration, genetic polymorphisms in PK/PD candidate genes, and clinical outcomes. These results suggest that drug monitoring could be useful to individualize the schedule of rituximab administration within the maintenance phase. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
Patients experience discomfort and compromised quality of life whilst waiting for hip replacement. Symptom duration may affect quality of life attained following surgery, but no population‐level evidence exists on the impact of symptom duration on pre‐ and post‐surgical outcomes. To read the full article, log in using your NHS OpenAthens details.
Fibromyalgia (FM) is a complex, centralized pain condition that is often difficult to diagnose and treat. FM is considered to have a genetic background due to its familial aggregation and due to findings from multiple candidate-gene studies implicating catecholaminergic and serotonergic neurotransmitter systems in chronic pain. However, a multi-factorial analysis of both genetic and environmental risk factors is lacking. A better characterization of the interplay of risk factors may assist in understanding the pathophysiology of FM, its clinical course, and assist in early diagnosis and treatment of the disorder. Open Access
Whether diabetes mellitus (DM) is associated with increased risk of knee osteoarthritis is uncertain. We evaluated associations of DM and biomarkers of abnormal glucose metabolism with incident radiographic knee osteoarthritis (RKOA), controlling for body mass index (BMI). To read the full article, log in using your NHS OpenAthens details.
To determine the association of effusion detected by physical examination with the prevalence of bone marrow lesions (BMLs) on magnetic resonance imaging (MRI), and the incidence/progression of BMLs over 3 years in subjects with knee osteoarthritis. To read the full article, log in using your NHS OpenAthens details.
Patellofemoral grind, but not joint line tenderness, may represent a clinical marker associated with accelerated cartilage volume loss over 4 years and increased risk of total knee replacement over 6 years. This simple clinical examination may provide clinicians with an inexpensive way to identify those at higher risk of disease progression who should be targeted for surveillance and management. To read the full article, log in using your MPFT NHS OpenAthens details.
We aimed to assess attitudes and factors affecting the decision-making vis-à-vis COVID-19 vaccination among patients with autoimmune rheumatic diseases (ARDs). To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
Frequent monitoring of early rheumatoid arthritis (RA) patients is required for achieving good outcomes. We studied the influence of text message (SMS) enhanced monitoring on early RA outcomes. To read the full article, log in using your NHS OpenAthens details.