%0 Journal Article %1 Ismagilov2001 %A Ismagilov, Rustem F. %A Rosmarin, David %A Kenis, Paul J. A. %A Chiu, Daniel T. %A Zhang, Wendy %A Stone, Howard A. %A Whitesides, George M. %C Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, and Division of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts 02138 %D 2001 %J Analytical Chemistry %K microchip microfluidics %N 19 %P 4682--4687 %R 10.1021/ac010374q %T Pressure-Driven Laminar Flow in Tangential Microchannels: an Elastomeric Microfluidic Switch %U http://dx.doi.org/10.1021/ac010374q %V 73 %X PMID: 11605847 This paper describes laminar fluid flow through a three-dimensional elastomeric microstructure formed by two microfluidic channels, fabricated in layers that contact one another face-to-face (typically at a 90° angle), with the fluid flows in tangential contact. There are two ways to control fluid flow through these tangentially connected microchannels. First, the flow profiles through the crossings are sensitive to the aspect ratio of the channels; the flow can be controlled by applying external pressure and changing this aspect ratio. Second, the flow direction of an individual laminar stream in multiphase laminar flow depends on the lateral position of the stream within the channel; this position can be controlled by injecting additional streams of fluid into the channel. We describe two microfluidic switches based on these two ways for controlling fluid flow through tangential microchannels and present theoretical arguments that explain the observed dependence of the flow profiles on the aspect ratio of the channels.

@article{Ismagilov2001, abstract = {PMID: 11605847 This paper describes laminar fluid flow through a three-dimensional elastomeric microstructure formed by two microfluidic channels, fabricated in layers that contact one another face-to-face (typically at a 90° angle), with the fluid flows in tangential contact. There are two ways to control fluid flow through these tangentially connected microchannels. First, the flow profiles through the crossings are sensitive to the aspect ratio of the channels; the flow can be controlled by applying external pressure and changing this aspect ratio. Second, the flow direction of an individual laminar stream in multiphase laminar flow depends on the lateral position of the stream within the channel; this position can be controlled by injecting additional streams of fluid into the channel. We describe two microfluidic switches based on these two ways for controlling fluid flow through tangential microchannels and present theoretical arguments that explain the observed dependence of the flow profiles on the aspect ratio of the channels.}, added-at = {2011-10-01T00:55:23.000+0200}, address = {Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, and Division of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts 02138}, author = {Ismagilov, Rustem F. and Rosmarin, David and Kenis, Paul J. A. and Chiu, Daniel T. and Zhang, Wendy and Stone, Howard A. and Whitesides, George M.}, biburl = {https://www.bibsonomy.org/bibtex/2be7e0a854035fc858fdbef17ee3a7647/afcallender}, citeulike-article-id = {3371500}, citeulike-linkout-0 = {http://dx.doi.org/10.1021/ac010374q}, citeulike-linkout-1 = {http://pubs.acs.org/doi/abs/10.1021/ac010374q}, day = 1, doi = {10.1021/ac010374q}, file = {Ismagilov2001.pdf:indexed\\Ismagilov2001.pdf:PDF}, groups = {public}, interhash = {080da8b14d522c3686cc1bebf170d750}, intrahash = {be7e0a854035fc858fdbef17ee3a7647}, journal = {Analytical Chemistry}, keywords = {microchip microfluidics}, month = {October}, number = 19, pages = {4682--4687}, posted-at = {2010-07-23 20:19:28}, priority = {2}, timestamp = {2011-10-01T00:55:23.000+0200}, title = {Pressure-Driven Laminar Flow in Tangential Microchannels: an Elastomeric Microfluidic Switch}, url = {http://dx.doi.org/10.1021/ac010374q}, username = {afcallender}, volume = 73, year = 2001 }