The dissolution of citrate-stabilized and poly(vinylpyrrolidone)-stabilized silver nanoparticles in water was studied by dialysis for up to 125 days at 5, 25, and 37 °C. The particles slowly dissolve into ions on a time scale of several days. However, in all cases, a limiting value of the released silver was observed, i.e., the particles did not completely dissolve. In some cases, the nanoparticles released up to 90\% of their weight. Formal kinetic data were computed. Rate and degree of dissolution depended on the functionalization as well as on the storage temperature. The release of silver led to a considerably increased toxicity of silver nanoparticles which had been stored in dispersion for several weeks toward human mesenchymal stem cells due to the increased concentration of silver ions. Consequently, �? aged�? (i.e., immersed) silver nanoparticles are much more toxic to cells than freshly prepared silver nanoparticles.
%0 Journal Article
%1 Kittler2010
%A Kittler, S.
%A Greulich, C.
%A Diendorf, J.
%A Köller, M.
%A Epple, M.
%D 2010
%J Chemistry of Materials
%K nanoparticles silver toxicity
%N 16
%P 4548–4554
%R 10.1021/cm100023p
%T Toxicity of Silver Nanoparticles Increases during Storage Because of Slow Dissolution under Release of Silver Ions
%U http://dx.doi.org/10.1021/cm100023p
%V 22
%X The dissolution of citrate-stabilized and poly(vinylpyrrolidone)-stabilized silver nanoparticles in water was studied by dialysis for up to 125 days at 5, 25, and 37 °C. The particles slowly dissolve into ions on a time scale of several days. However, in all cases, a limiting value of the released silver was observed, i.e., the particles did not completely dissolve. In some cases, the nanoparticles released up to 90\% of their weight. Formal kinetic data were computed. Rate and degree of dissolution depended on the functionalization as well as on the storage temperature. The release of silver led to a considerably increased toxicity of silver nanoparticles which had been stored in dispersion for several weeks toward human mesenchymal stem cells due to the increased concentration of silver ions. Consequently, �? aged�? (i.e., immersed) silver nanoparticles are much more toxic to cells than freshly prepared silver nanoparticles.
@article{Kittler2010,
abstract = {The dissolution of citrate-stabilized and poly(vinylpyrrolidone)-stabilized silver nanoparticles in water was studied by dialysis for up to 125 days at 5, 25, and 37 °C. The particles slowly dissolve into ions on a time scale of several days. However, in all cases, a limiting value of the released silver was observed, i.e., the particles did not completely dissolve. In some cases, the nanoparticles released up to 90\% of their weight. Formal kinetic data were computed. Rate and degree of dissolution depended on the functionalization as well as on the storage temperature. The release of silver led to a considerably increased toxicity of silver nanoparticles which had been stored in dispersion for several weeks toward human mesenchymal stem cells due to the increased concentration of silver ions. Consequently, �? aged�? (i.e., immersed) silver nanoparticles are much more toxic to cells than freshly prepared silver nanoparticles.},
added-at = {2011-10-01T00:26:04.000+0200},
author = {Kittler, S. and Greulich, C. and Diendorf, J. and Köller, M. and Epple, M.},
biburl = {https://www.bibsonomy.org/bibtex/23a3875db79ce02e5bf226c2899ea4631/afcallender},
citeulike-article-id = {7591538},
citeulike-linkout-0 = {http://dx.doi.org/10.1021/cm100023p},
citeulike-linkout-1 = {http://pubs.acs.org/doi/abs/10.1021/cm100023p},
doi = {10.1021/cm100023p},
file = {Kittler2010.pdf:indexed\\Kittler2010.pdf:PDF},
groups = {public},
interhash = {3ffc7d7be972694145b1a48bb00e9da6},
intrahash = {3a3875db79ce02e5bf226c2899ea4631},
journal = {Chemistry of Materials},
keywords = {nanoparticles silver toxicity},
number = 16,
pages = {4548–4554},
posted-at = {2010-08-09 04:56:52},
priority = {2},
timestamp = {2011-10-01T00:26:04.000+0200},
title = {Toxicity of Silver Nanoparticles Increases during Storage Because of Slow Dissolution under Release of Silver Ions},
url = {http://dx.doi.org/10.1021/cm100023p},
username = {afcallender},
volume = 22,
year = 2010
}