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1Pyrazolo4,3-e1,2,4-triazolo1,5-cpyrimidine derivatives as highly potent and selective human A(3) adenosine receptor antagonists: influence of the chain at the N(8) pyrazole nitrogen
P. Baraldi, B. Cacciari, R. Romagnoli, G. Spalluto, S. Moro, K. Klotz, E. Leung, K. Varani, S. Gessi, S. Merighi and 1 other author(s). J Med Chem, 43 (25): 4768-80 (December 2000)Baraldi, P G Cacciari, B Romagnoli, R Spalluto, G Moro, S Klotz, K N Leung, E Varani, K Gessi, S Merighi, S Borea, P A Research Support, Non-U.S. Gov't United states Journal of medicinal chemistry J Med Chem. 2000 Dec 14;43(25):4768-80..
14 years ago by @pharmawuerz
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inhibitors
Cricetinae
Humans
Radioligand
CHO
Pyrazoles/*chemistry
Purinergic
Assay
Animals
Receptor
Molecular
Cyclic
P1/*antagonists
Pyrimidines/*chemical
AMP/biosynthesis
Relationship
synthesis/chemistry/pharmacology
Models,
Structure-Activity
Adenosine
Structure
Cell
inhibitorsCricetinaeHumansRadioligandCHOPyrazoles/*chemistryPurinergicAssayAnimalsReceptorMolecularCyclicP1/*antagonistsPyrimidines/*chemicalAMP/biosynthesisRelationshipsynthesis/chemistry/pharmacologyModels,Structure-ActivityAdenosineStructureCell
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1Synthesis, biological evaluation, and molecular modeling of ribose-modified adenosine analogues as adenosine receptor agonists
L. Cappellacci, P. Franchetti, M. Pasqualini, R. Petrelli, P. Vita, A. Lavecchia, E. Novellino, B. Costa, C. Martini, K. Klotz and 1 other author(s). J Med Chem, 48 (5): 1550-62 (March 2005)Cappellacci, Loredana Franchetti, Palmarisa Pasqualini, Michela Petrelli, Riccardo Vita, Patrizia Lavecchia, Antonio Novellino, Ettore Costa, Barbara Martini, Claudia Klotz, Karl-Norbert Grifantini, Mario In Vitro Research Support, Non-U.S. Gov't United States Journal of medicinal chemistry J Med Chem. 2005 Mar 10;48(5):1550-62..
14 years ago by @pharmawuerz
show all tags
derivatives/*chemical
Adenosine/*analogs
Cricetinae
&
Radioligand
Rats
Competitive
Animals
Receptor
Cyclase/antagonists
Models,
Brain/metabolism
inhibitors
Binding,
Cricetulus
Humans
CHO
Adenylate
Purinergic
P1/*agonists/chemistry
Assay
Molecular
Ribose/*chemistry
synthesis/pharmacology
Cell
derivatives/*chemicalAdenosine/*analogsCricetinae&RadioligandRatsCompetitiveAnimalsReceptorCyclase/antagonistsModels,Brain/metabolisminhibitorsBinding,CricetulusHumansCHOAdenylatePurinergicP1/*agonists/chemistryAssayMolecularRibose/*chemistrysynthesis/pharmacologyCell
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1Synthesis, biological activity, and molecular modeling investigation of new pyrazolo4,3-e-1,2,4-triazolo1,5-cpyrimidine derivatives as human A(3) adenosine receptor antagonists
P. Baraldi, B. Cacciari, S. Moro, G. Spalluto, G. Pastorin, T. Ros, K. Klotz, K. Varani, S. Gessi, and P. Borea. J Med Chem, 45 (4): 770-80 (February 2002)Baraldi, Pier Giovanni Cacciari, Barbara Moro, Stefano Spalluto, Giampiero Pastorin, Giorgia Da Ros, Tatiana Klotz, Karl-Norbert Varani, Katia Gessi, Stefania Borea, Pier Andrea Research Support, Non-U.S. Gov't United States Journal of medicinal chemistry J Med Chem. 2002 Feb 14;45(4):770-80..
14 years ago by @pharmawuerz
show all tags
Structure,
Cricetinae
Secondary
Humans
Radioligand
CHO
Purinergic
Transfection
Protein
Assay
Animals
inhibitors/metabolism
Receptor
Molecular
Cyclic
P1/*antagonists
Pyrimidines/*chemical
AMP/biosynthesis
Relationship
synthesis/chemistry/pharmacology
Models,
Structure-Activity
Adenosine
Cell
Structure,CricetinaeSecondaryHumansRadioligandCHOPurinergicTransfectionProteinAssayAnimalsinhibitors/metabolismReceptorMolecularCyclicP1/*antagonistsPyrimidines/*chemicalAMP/biosynthesisRelationshipsynthesis/chemistry/pharmacologyModels,Structure-ActivityAdenosineCell
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1Mechanisms of altered excitation-contraction coupling in canine tachycardia-induced heart failure, II: model studies.
R. Winslow, J. Rice, S. Jafri, E. Marb�n, and B. O'Rourke. Circ. Res., 84 (5): 571--586 (March 1999)
16 years ago by @hake
show all tags
Hydroxy
Preconditioning,
Health
{C}a$^{2+}$-Transporting
Failure,
Century,
Ion
Fractions,
Myocardial,
Techniques,
Emergency
Animals,
United
Research
CD8,
Time
Cells,
Programs,
Rectifying,
Phosphates,
National
Membrane
Antigens,
Patch-Clamp
Voltage-Gated,
20th
Dinucleoside
Channel
Membranes,
Contraction,
Potentials,
Rats,
States,
Congestive,
Apoptosis,
Ischemia,
Services,
ATPase,
Acids,
Models,
Potassium
Heart
Guinea
Myocardium,
Inwardly
Diuretics,
Non-U.S.
Enzyme
Flavoproteins,
Heart,
Mice,
Calcium,
Fusion,
Non-P.H.S.,
Humans,
Hamsters,
Intracellular
Gating,
Glyburide,
Calcium
Dogs,
CHO
Electrophysiology,
Factors,
U.S.
Sarcolemma,
Diazoxide,
Cell
Pigs,
History,
Channels,
Support,
Sodium-Calcium
Reticulum,
P.H.S.,
Sodium,
Forecasting,
Medical
Exchanger,
Rabbits,
Action
Thiazide,
Mitochondria,
Decanoic
Cardiovascular,
Blockers,
Sarcoplasmic
Gov't,
Regional
Ischemic
Subcellular
10082479
Proteins,
Inhibitors,
Myocardial
California,
Cultured,
HydroxyPreconditioning,Health{C}a$^{2+}$-TransportingFailure,Century,IonFractions,Myocardial,Techniques,EmergencyAnimals,UnitedResearchCD8,TimeCells,Programs,Rectifying,Phosphates,NationalMembraneAntigens,Patch-ClampVoltage-Gated,20thDinucleosideChannelMembranes,Contraction,Potentials,Rats,States,Congestive,Apoptosis,Ischemia,Services,ATPase,Acids,Models,PotassiumHeartGuineaMyocardium,InwardlyDiuretics,Non-U.S.EnzymeFlavoproteins,Heart,Mice,Calcium,Fusion,Non-P.H.S.,Humans,Hamsters,IntracellularGating,Glyburide,CalciumDogs,CHOElectrophysiology,Factors,U.S.Sarcolemma,Diazoxide,CellPigs,History,Channels,Support,Sodium-CalciumReticulum,P.H.S.,Sodium,Forecasting,MedicalExchanger,Rabbits,ActionThiazide,Mitochondria,DecanoicCardiovascular,Blockers,SarcoplasmicGov't,RegionalIschemicSubcellular10082479Proteins,Inhibitors,MyocardialCalifornia,Cultured,
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1Mechanisms of altered excitation-contraction coupling in canine tachycardia-induced heart failure, I: experimental studies.
B. O'Rourke, D. Kass, G. Tomaselli, S. K��b, R. Tunin, and E. Marb�n. Circ. Res., 84 (5): 562--570 (March 1999)
16 years ago by @hake
show all tags
Hydroxy
Preconditioning,
Health
{C}a$^{2+}$-Transporting
Failure,
Century,
Ion
Fractions,
Myocardial,
Techniques,
Emergency
Animals,
Female,
United
Research
CD8,
Time
Cells,
Programs,
Rectifying,
Phosphates,
National
Membrane
Antigens,
Patch-Clamp
20th
Dinucleoside
Channel
Membranes,
Contraction,
Potentials,
Rats,
Congestive,
Apoptosis,
Ischemia,
Services,
Blotting,
ATPase,
Acids,
Models,
Potassium
Heart
Guinea
Myocardium,
Inwardly
Diuretics,
Non-U.S.
Enzyme
Flavoproteins,
Heart,
Adrenergic,
Mice,
Calcium,
Fusion,
Non-P.H.S.,
Humans,
Hamsters,
Intracellular
Gating,
Glyburide,
Calcium
Tachycardia,
Dogs,
CHO
Calcium-Binding
Electrophysiology,
Receptors,
Factors,
U.S.
Sarcolemma,
Diazoxide,
Cell
Pigs,
History,
Channels,
Support,
Sodium-Calcium
Reticulum,
P.H.S.,
Sodium,
Male,
Forecasting,
Medical
Exchanger,
Rabbits,
Action
Thiazide,
Mitochondria,
Decanoic
Cardiovascular,
Blockers,
Sarcoplasmic
Gov't,
Regional
Ischemic
Subcellular
Proteins,
Inhibitors,
Myocardial
California,
Cultured,
HydroxyPreconditioning,Health{C}a$^{2+}$-TransportingFailure,Century,IonFractions,Myocardial,Techniques,EmergencyAnimals,Female,UnitedResearchCD8,TimeCells,Programs,Rectifying,Phosphates,NationalMembraneAntigens,Patch-Clamp20thDinucleosideChannelMembranes,Contraction,Potentials,Rats,Congestive,Apoptosis,Ischemia,Services,Blotting,ATPase,Acids,Models,PotassiumHeartGuineaMyocardium,InwardlyDiuretics,Non-U.S.EnzymeFlavoproteins,Heart,Adrenergic,Mice,Calcium,Fusion,Non-P.H.S.,Humans,Hamsters,IntracellularGating,Glyburide,CalciumTachycardia,Dogs,CHOCalcium-BindingElectrophysiology,Receptors,Factors,U.S.Sarcolemma,Diazoxide,CellPigs,History,Channels,Support,Sodium-CalciumReticulum,P.H.S.,Sodium,Male,Forecasting,MedicalExchanger,Rabbits,ActionThiazide,Mitochondria,DecanoicCardiovascular,Blockers,SarcoplasmicGov't,RegionalIschemicSubcellularProteins,Inhibitors,MyocardialCalifornia,Cultured,
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BibSonomy

publications (hide)5 displayallpublications onlypublications per page5102050100 sort byadded attitleauthorpublication dateentry typehelp for advanced sorting... RSSBibTeXRDFmore...

1Pyrazolo4,3-e1,2,4-triazolo1,5-cpyrimidine derivatives as highly potent and selective human A(3) adenosine receptor antagonists: influence of the chain at the N(8) pyrazole nitrogen

1Synthesis, biological evaluation, and molecular modeling of ribose-modified adenosine analogues as adenosine receptor agonists

1Synthesis, biological activity, and molecular modeling investigation of new pyrazolo4,3-e-1,2,4-triazolo1,5-cpyrimidine derivatives as human A(3) adenosine receptor antagonists

1Mechanisms of altered excitation-contraction coupling in canine tachycardia-induced heart failure, II: model studies.

1Mechanisms of altered excitation-contraction coupling in canine tachycardia-induced heart failure, I: experimental studies.

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publications (hide)5
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10
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