M. > ENERGY Myocytes,

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1Gq-mediated Ca2+ signals inhibit adenylyl cyclases 5/6 in vascular smooth muscle cells
K. von Hayn, R. Werthmann, V. Nikolaev, L. Hommers, M. Lohse, and M. Bunemann. Am J Physiol Cell Physiol, 298 (2): C324-32 (February 2010)von Hayn, Kathrin Werthmann, Ruth C Nikolaev, Viacheslav O Hommers, Leif G Lohse, Martin J Bunemann, Moritz Research Support, Non-U.S. Gov't United States American journal of physiology. Cell physiology Am J Physiol Cell Physiol. 2010 Feb;298(2):C324-32. Epub 2009 Nov 4..
14 years ago by @pharmawuerz
show all tags
Techniques
effects/*enzymology
Nucleotide
inhibitors/genetics/*metabolism
Biosensing
Muscle/drug
effects
inhibitors/metabolism
AMP/*metabolism
Cyclase/antagonists
Inhibitors/pharmacology
Uridine
Transfer
Mice
Resonance
Factors
RNA
Humans
Adenylate
Time
Phosphodiesterases,
Vascular/drug
Muscle,
Xanthines/pharmacology
Dose-Response
*Calcium
Cultured
Relationship,
Smooth
Energy
Cell
Phosphodiesterase
Vasoconstriction
Interference
&
Smooth,
Protein
1/antagonists
Type
Animals
Receptor
Cyclic
beta-Agonists/pharmacology
Isoenzymes/antagonists
Isoproterenol/pharmacology
Purinergic/metabolism
Myocytes,
Gq-G11/*metabolism
Fluorescence
Triphosphate/metabolism
Transfection
Adrenergic
Vasodilation
Aorta/enzymology
alpha
GTP-Binding
Signaling/drug
Subunits,
Drug
Techniqueseffects/*enzymologyNucleotideinhibitors/genetics/*metabolismBiosensingMuscle/drugeffectsinhibitors/metabolismAMP/*metabolismCyclase/antagonistsInhibitors/pharmacologyUridineTransferMiceResonanceFactorsRNAHumansAdenylateTimePhosphodiesterases,Vascular/drugMuscle,Xanthines/pharmacologyDose-Response*CalciumCulturedRelationship,SmoothEnergyCellPhosphodiesteraseVasoconstrictionInterference&Smooth,Protein1/antagonistsTypeAnimalsReceptorCyclicbeta-Agonists/pharmacologyIsoenzymes/antagonistsIsoproterenol/pharmacologyPurinergic/metabolismMyocytes,Gq-G11/*metabolismFluorescenceTriphosphate/metabolismTransfectionAdrenergicVasodilationAorta/enzymologyalphaGTP-BindingSignaling/drugSubunits,Drug
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1Spatiotemporal dynamics of beta-adrenergic cAMP signals and L-type Ca2+ channel regulation in adult rat ventricular myocytes: role of phosphodiesterases
J. Leroy, A. Abi-Gerges, V. Nikolaev, W. Richter, P. Lechene, J. Mazet, M. Conti, R. Fischmeister, and G. Vandecasteele. Circ Res, 102 (9): 1091-100 (May 2008)Leroy, Jerome Abi-Gerges, Aniella Nikolaev, Viacheslav O Richter, Wito Lechene, Patrick Mazet, Jean-Luc Conti, Marco Fischmeister, Rodolphe Vandecasteele, Gregoire HD20788/HD/NICHD NIH HHS/United States Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't United States Circulation research Circ Res. 2008 May 9;102(9):1091-100. Epub 2008 Mar 27..
14 years ago by @pharmawuerz
show all tags
Techniques
Fluorescence/methods
Nucleotide
Rats
Biosensing
Wistar
Exchange
effects
*Myocardial
Potentials
AMP/*metabolism
Inhibitors/pharmacology
Kinetics
Transfer
Resonance
effects/*metabolism
Calcium
Activation
Phosphodiesterases,
Sarcolemma/metabolism
Dose-Response
L-Type/*metabolism
Membrane
Cultured
Relationship,
Energy
Cell
Phosphodiesterase
&
inhibitors/*metabolism
Contraction/drug
4/antagonists
Channels,
Transduction/drug
Ventricles/metabolism
Kinases/metabolism
Protein
Cation
Type
Cardiac/drug
Animals
Receptor
Nucleotide-Gated
Cyclic
3/antagonists
Quinolones/pharmacology
Microscopy,
beta/drug
beta-Agonists/pharmacology
Cytosol/metabolism
Isoproterenol/pharmacology
Factors/genetics/metabolism
Heart
Phosphorylation
Myocytes,
effects/enzymology/*metabolism
Male
Fluorescence
Transfection
Adrenergic
Guanine
*Signal
Channels/genetics/metabolism
Enzyme
AMP-Dependent
4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone/pharmacology
Drug
TechniquesFluorescence/methodsNucleotideRatsBiosensingWistarExchangeeffects*MyocardialPotentialsAMP/*metabolismInhibitors/pharmacologyKineticsTransferResonanceeffects/*metabolismCalciumActivationPhosphodiesterases,Sarcolemma/metabolismDose-ResponseL-Type/*metabolismMembraneCulturedRelationship,EnergyCellPhosphodiesterase&inhibitors/*metabolismContraction/drug4/antagonistsChannels,Transduction/drugVentricles/metabolismKinases/metabolismProteinCationTypeCardiac/drugAnimalsReceptorNucleotide-GatedCyclic3/antagonistsQuinolones/pharmacologyMicroscopy,beta/drugbeta-Agonists/pharmacologyCytosol/metabolismIsoproterenol/pharmacologyFactors/genetics/metabolismHeartPhosphorylationMyocytes,effects/enzymology/*metabolismMaleFluorescenceTransfectionAdrenergicGuanine*SignalChannels/genetics/metabolismEnzymeAMP-Dependent4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone/pharmacologyDrug
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1Beta2-adrenergic receptor redistribution in heart failure changes cAMP compartmentation
V. Nikolaev, A. Moshkov, A. Lyon, M. Miragoli, P. Novak, H. Paur, M. Lohse, Y. Korchev, S. Harding, and J. Gorelik. Science, 327 (5973): 1653-7 (March 2010)Nikolaev, Viacheslav O Moshkov, Alexey Lyon, Alexander R Miragoli, Michele Novak, Pavel Paur, Helen Lohse, Martin J Korchev, Yuri E Harding, Sian E Gorelik, Julia 084064/Wellcome Trust/United Kingdom Biotechnology and Biological Sciences Research Council/United Kingdom Medical Research Council/United Kingdom Research Support, Non-U.S. Gov't United States Science (New York, N.Y.) Science. 2010 Mar 26;327(5973):1653-7. Epub 2010 Feb 25..
14 years ago by @pharmawuerz
show all tags
Cardiac/*metabolism/ultrastructure
Compartmentation
Failure/*metabolism/*pathology
Sarcolemma/*metabolism/ultrastructure
Rats
Kinases/metabolism
Knockout
Protein
Chronic
Animals
Receptor
beta-1/genetics/metabolism
Cyclic
AMP/*metabolism
Microscopy/methods
Transfer
Mice
Resonance
Transduction
Cytosol/metabolism
Heart
Disease
Myocytes,
Membrane/*metabolism/ultrastructure
Male
Fluorescence
Transgenic
Adrenergic
beta-2/genetics/*metabolism
Energy
Signal
AMP-Dependent
Sprague-Dawley
Cell
Cardiac/*metabolism/ultrastructureCompartmentationFailure/*metabolism/*pathologySarcolemma/*metabolism/ultrastructureRatsKinases/metabolismKnockoutProteinChronicAnimalsReceptorbeta-1/genetics/metabolismCyclicAMP/*metabolismMicroscopy/methodsTransferMiceResonanceTransductionCytosol/metabolismHeartDiseaseMyocytes,Membrane/*metabolism/ultrastructureMaleFluorescenceTransgenicAdrenergicbeta-2/genetics/*metabolismEnergySignalAMP-DependentSprague-DawleyCell
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1Cyclic AMP imaging in adult cardiac myocytes reveals far-reaching beta1-adrenergic but locally confined beta2-adrenergic receptor-mediated signaling
V. Nikolaev, M. Bunemann, E. Schmitteckert, M. Lohse, and S. Engelhardt. Circ Res, 99 (10): 1084-91 (November 2006)Nikolaev, Viacheslav O Bunemann, Moritz Schmitteckert, Eva Lohse, Martin J Engelhardt, Stefan Research Support, Non-U.S. Gov't United States Circulation research Circ Res. 2006 Nov 10;99(10):1084-91. Epub 2006 Oct 12..
14 years ago by @pharmawuerz
show all tags
Structure,
Cardiac/cytology/*metabolism
Tertiary
Ion
Channels/biosynthesis/genetics/metabolism
Phosphoric
AMP/genetics/*metabolism
Biosensing
Protein
Animals
Receptor
Cyclic
Diester
Mice
Resonance
Transduction
beta-2/*metabolism
Models,
beta-Agonists/pharmacology
Transfer/methods
Myocytes,
Humans
beta-1/*metabolism
Fluorescence
Transgenic
Adrenergic
Techniques/methods
Molecular
Hydrolases/metabolism
Energy
Signal
Isoenzymes/metabolism
Structure,Cardiac/cytology/*metabolismTertiaryIonChannels/biosynthesis/genetics/metabolismPhosphoricAMP/genetics/*metabolismBiosensingProteinAnimalsReceptorCyclicDiesterMiceResonanceTransductionbeta-2/*metabolismModels,beta-Agonists/pharmacologyTransfer/methodsMyocytes,Humansbeta-1/*metabolismFluorescenceTransgenicAdrenergicTechniques/methodsMolecularHydrolases/metabolismEnergySignalIsoenzymes/metabolism
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1Fluorescence resonance energy transfer-based analysis of cAMP dynamics in live neonatal rat cardiac myocytes reveals distinct functions of compartmentalized phosphodiesterases
M. Mongillo, T. McSorley, S. Evellin, A. Sood, V. Lissandron, A. Terrin, E. Huston, A. Hannawacker, M. Lohse, T. Pozzan and 2 other author(s). Circ Res, 95 (1): 67-75 (July 2004)Mongillo, Marco McSorley, Theresa Evellin, Sandrine Sood, Arvind Lissandron, Valentina Terrin, Anna Huston, Elaine Hannawacker, Annette Lohse, Martin J Pozzan, Tullio Houslay, Miles D Zaccolo, Manuela Research Support, Non-U.S. Gov't United States Circulation research Circ Res. 2004 Jul 9;95(1):67-75. Epub 2004 Jun 3..
14 years ago by @pharmawuerz
show all tags
Phosphodiesterase
&
Nucleotide
Rats
Type
3
Animals
Newborn
4
Cyclic
AMP/*metabolism
Inhibitors/pharmacology
Norepinephrine/pharmacology
Transfer
Resonance
Animals,
Myocytes,
Phosphodiesterases/analysis/antagonists
3',5'-Cyclic-AMP
Fluorescence
Phosphodiesterases,
inhibitors/*physiology
Adrenergic
Cardiac/*enzymology
Energy
alpha-Agonists/pharmacology
Phosphodiesterase&NucleotideRatsType3AnimalsNewborn4CyclicAMP/*metabolismInhibitors/pharmacologyNorepinephrine/pharmacologyTransferResonanceAnimals,Myocytes,Phosphodiesterases/analysis/antagonists3',5'-Cyclic-AMPFluorescencePhosphodiesterases,inhibitors/*physiologyAdrenergicCardiac/*enzymologyEnergyalpha-Agonists/pharmacology
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1Cytoplasmic cAMP concentrations in intact cardiac myocytes
R. Iancu, G. Ramamurthy, S. Warrier, V. Nikolaev, M. Lohse, S. Jones, and R. Harvey. Am J Physiol Cell Physiol, 295 (2): C414-22 (August 2008)Iancu, Radu V Ramamurthy, Gopalakrishnan Warrier, Sunita Nikolaev, Viacheslav O Lohse, Martin J Jones, Stephen W Harvey, Robert D Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't United States American journal of physiology. Cell physiology Am J Physiol Cell Physiol. 2008 Aug;295(2):C414-22. Epub 2008 Jun 11..
14 years ago by @pharmawuerz
show all tags
Luminescent
Pigs
Compartmentation
Techniques
&
Nucleotide
Acetylcholine/pharmacology
Biological
Biosensing
Exchange
1-Methyl-3-isobutylxanthine/pharmacology
Animals
Receptor
Cyclic
Simulation
M2/agonists
Transfer
Resonance
effects/*metabolism
Models,
beta-Agonists/pharmacology
inhibitors
Factors/genetics/metabolism
Guinea
Myocytes,
beta-1/antagonists
Cytoplasm/*metabolism
Proteins/genetics/metabolism
Fluorescence
Muscarinic
Cardiac/cytology/drug
Transfection
Adrenergic
Guanine
Transduction/*physiology
Computer
Cultured
Energy
Signal
Cell
AMP/analysis/*metabolism
LuminescentPigsCompartmentationTechniques&NucleotideAcetylcholine/pharmacologyBiologicalBiosensingExchange1-Methyl-3-isobutylxanthine/pharmacologyAnimalsReceptorCyclicSimulationM2/agonistsTransferResonanceeffects/*metabolismModels,beta-Agonists/pharmacologyinhibitorsFactors/genetics/metabolismGuineaMyocytes,beta-1/antagonistsCytoplasm/*metabolismProteins/genetics/metabolismFluorescenceMuscarinicCardiac/cytology/drugTransfectionAdrenergicGuanineTransduction/*physiologyComputerCulturedEnergySignalCellAMP/analysis/*metabolism
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1Intracellular Na$^+$ and Na$^+$ pump rate in rat and rabbit ventricular myocytes.
S. Despa, M. Islam, S. Pogwizd, and D. Bers. J. Physiol., 539 (Pt 1): 133--143 (February 2002)
16 years ago by @hake
show all tags
Strophanthidin,
Calcium,
Failure,
Biological,
Capacitance,
Electric
Simulation,
Size,
Animal,
Photobleaching,
als,
Transport,
Transfer,
Stimulation,
Intracellular
Sodium
Techniques,
Resonance
Active,
Ventricles,
After
Animals,
Disease
Separation,
Research
Osmolar
Cells,
Physiological,
Tetrodotoxin,
Vitro,
U.S.
Concentration,
Fluorescent
Membrane
Sarcolemma,
Muscle
Energy
Cell
Patch-Clamp
Multiphoton,
Antiporter,
Channel
Calibration,
Membranes,
Distribution,
Channels,
Biological
Contraction,
Potentials,
Support,
Sodium-Calcium
Rats,
Congestive,
P.H.S.,
Sodium,
ATPase,
Adaptation,
Microscopy,
Nickel,
Models,
Exchanger,
Rabbits,
Space,
Action
Sodium-Hydrogen
Heart
Benzofurans,
{N}a$^{+}$-{K}$^{+}$-Exchanging
Myocytes,
In
Myocardium,
11850496
Blockers,
Gov't,
Fluorescence
Recovery
Comparative
Fluorescence,
Tissue
Diffusion,
Cyclic,
Cardiac,
Non-U.S.
Myocardial
Ethers,
Computer
Study,
Diastole,
Fluid,
Dyes,
Potenti,
Cultured,
Strophanthidin,Calcium,Failure,Biological,Capacitance,ElectricSimulation,Size,Animal,Photobleaching,als,Transport,Transfer,Stimulation,IntracellularSodiumTechniques,ResonanceActive,Ventricles,AfterAnimals,DiseaseSeparation,ResearchOsmolarCells,Physiological,Tetrodotoxin,Vitro,U.S.Concentration,FluorescentMembraneSarcolemma,MuscleEnergyCellPatch-ClampMultiphoton,Antiporter,ChannelCalibration,Membranes,Distribution,Channels,BiologicalContraction,Potentials,Support,Sodium-CalciumRats,Congestive,P.H.S.,Sodium,ATPase,Adaptation,Microscopy,Nickel,Models,Exchanger,Rabbits,Space,ActionSodium-HydrogenHeartBenzofurans,{N}a$^{+}$-{K}$^{+}$-ExchangingMyocytes,InMyocardium,11850496Blockers,Gov't,FluorescenceRecoveryComparativeFluorescence,TissueDiffusion,Cyclic,Cardiac,Non-U.S.MyocardialEthers,ComputerStudy,Diastole,Fluid,Dyes,Potenti,Cultured,
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1Differential integration of Ca2+-calmodulin signal in intact ventricular myocytes at low and high affinity Ca2+-calmodulin targets.
Q. Song, J. Saucerman, J. Bossuyt, and D. Bers. J Biol Chem, 283 (46): 31531--31540 (November 2008)
16 years ago by @hake
show all tags
Humans;
Calcium,
Survival;
Techniques;
Sequence;
Sequence
metabolism;
Biosensing
Cultured;
Protein
Signaling;
Substrate
Biological;
Animals;
chemistry/genetics/metabolism;
Resonance
cytology/metabolism;
Models,
Transfer;
Calmodulin-Binding
Acid
Calcium
Myocytes,
Aging,
Fluorescence
Cells,
physiology;
Rabbits;
Calmodulin,
Molecular
Proteins,
Specificity
Binding;
Cardiac,
Amino
Energy
Data;
Cell
Humans;Calcium,Survival;Techniques;Sequence;Sequencemetabolism;BiosensingCultured;ProteinSignaling;SubstrateBiological;Animals;chemistry/genetics/metabolism;Resonancecytology/metabolism;Models,Transfer;Calmodulin-BindingAcidCalciumMyocytes,Aging,FluorescenceCells,physiology;Rabbits;Calmodulin,MolecularProteins,SpecificityBinding;Cardiac,AminoEnergyData;Cell
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1Intracellular Na$^+$ concentration is elevated in heart failure but Na/K pump function is unchanged.
S. Despa, M. Islam, C. Weber, S. Pogwizd, and D. Bers. Circulation, 105 (21): 2543--2548 (May 2002)
16 years ago by @hake
show all tags
Strophanthidin,
Calcium,
Failure,
Biological,
Capacitance,
Electric
Simulation,
Size,
Animal,
Photobleaching,
als,
Transport,
Transfer,
Stimulation,
Intracellular
Sodium
Techniques,
Resonance
Active,
Ventricles,
After
Animals,
12034663
Disease
Separation,
Research
Cells,
Physiological,
Tetrodotoxin,
Vitro,
U.S.
Membrane
Sarcolemma,
Muscle
Energy
Cell
Patch-Clamp
Multiphoton,
Antiporter,
Channel
Distribution,
Channels,
Biological
Contraction,
Potentials,
Support,
Sodium-Calcium
Rats,
Congestive,
P.H.S.,
Sodium,
ATPase,
Adaptation,
Microscopy,
Nickel,
Models,
Exchanger,
Rabbits,
Space,
Action
Sodium-Hydrogen
Heart
{N}a$^{+}$-{K}$^{+}$-Exchanging
Myocytes,
In
Myocardium,
Blockers,
Gov't,
Fluorescence
Recovery
Comparative
Fluorescence,
Tissue
Diffusion,
Cardiac,
Non-U.S.
Myocardial
Computer
Study,
Diastole,
Fluid,
Potenti,
Cultured,
Strophanthidin,Calcium,Failure,Biological,Capacitance,ElectricSimulation,Size,Animal,Photobleaching,als,Transport,Transfer,Stimulation,IntracellularSodiumTechniques,ResonanceActive,Ventricles,AfterAnimals,12034663DiseaseSeparation,ResearchCells,Physiological,Tetrodotoxin,Vitro,U.S.MembraneSarcolemma,MuscleEnergyCellPatch-ClampMultiphoton,Antiporter,ChannelDistribution,Channels,BiologicalContraction,Potentials,Support,Sodium-CalciumRats,Congestive,P.H.S.,Sodium,ATPase,Adaptation,Microscopy,Nickel,Models,Exchanger,Rabbits,Space,ActionSodium-HydrogenHeart{N}a$^{+}$-{K}$^{+}$-ExchangingMyocytes,InMyocardium,Blockers,Gov't,FluorescenceRecoveryComparativeFluorescence,TissueDiffusion,Cardiac,Non-U.S.MyocardialComputerStudy,Diastole,Fluid,Potenti,Cultured,
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1Genetic manipulation of calcium-handling proteins in cardiac myocytes. II. Mathematical modeling studies.
P. Coutu, and J. Metzger. Am. J. Physiol. Heart Circ. Physiol., 288 (2): H613--H631 (February 2005)
16 years ago by @hake
show all tags
{C}a$^{2+}$-Transporting
Calcium,
beta-Agonists,
Sprague-Dawley,
Contraction,
Potentials,
Parvalbumins,
Rats,
Reticulum,
Sarcomeres,
Isoproterenol,
ATPase,
Reproducibility
Techniques,
Transfer
Models,
rgic
Animals,
Results,
Myocytes,
Female,
Metabolism,
Cardiovascular,
Sarcoplasmic
Cells,
Systole,
15331371
Adrene,
Expression,
Gene
Cardiac,
Myocardial
of
Membrane
Diastole,
Energy
Cultured,
{C}a$^{2+}$-TransportingCalcium,beta-Agonists,Sprague-Dawley,Contraction,Potentials,Parvalbumins,Rats,Reticulum,Sarcomeres,Isoproterenol,ATPase,ReproducibilityTechniques,TransferModels,rgicAnimals,Results,Myocytes,Female,Metabolism,Cardiovascular,SarcoplasmicCells,Systole,15331371Adrene,Expression,GeneCardiac,MyocardialofMembraneDiastole,EnergyCultured,
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1Na/K pump-induced Na(i) gradients in rat ventricular myocytes measured with two-photon microscopy.
S. Despa, J. Kocksk�mper, L. Blatter, and D. Bers. Biophys. J., 87 (2): 1360--1368 (August 2004)
16 years ago by @hake
show all tags
Multiphoton,
Biological,
Simulation,
Biological
Photobleaching,
Support,
Rats,
Transport,
Transfer,
P.H.S.,
Sodium,
ATPase,
Microscopy,
Resonance
Models,
Active,
Ventricles,
After
Animals,
Heart
15298938
{N}a$^{+}$-{K}$^{+}$-Exchanging
Myocytes,
Gov't,
Research
Fluorescence
Cells,
Recovery
Fluorescence,
U.S.
Non-U.S.
Cardiac,
Computer
Energy
Cultured,
Multiphoton,Biological,Simulation,BiologicalPhotobleaching,Support,Rats,Transport,Transfer,P.H.S.,Sodium,ATPase,Microscopy,ResonanceModels,Active,Ventricles,AfterAnimals,Heart15298938{N}a$^{+}$-{K}$^{+}$-ExchangingMyocytes,Gov't,ResearchFluorescenceCells,RecoveryFluorescence,U.S.Non-U.S.Cardiac,ComputerEnergyCultured,
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publications (hide)11
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1Gq-mediated Ca2+ signals inhibit adenylyl cyclases 5/6 in vascular smooth muscle cells

1Spatiotemporal dynamics of beta-adrenergic cAMP signals and L-type Ca2+ channel regulation in adult rat ventricular myocytes: role of phosphodiesterases

1Beta2-adrenergic receptor redistribution in heart failure changes cAMP compartmentation

1Cyclic AMP imaging in adult cardiac myocytes reveals far-reaching beta1-adrenergic but locally confined beta2-adrenergic receptor-mediated signaling

1Fluorescence resonance energy transfer-based analysis of cAMP dynamics in live neonatal rat cardiac myocytes reveals distinct functions of compartmentalized phosphodiesterases

1Cytoplasmic cAMP concentrations in intact cardiac myocytes

1Intracellular Na$^+$ and Na$^+$ pump rate in rat and rabbit ventricular myocytes.

1Differential integration of Ca2+-calmodulin signal in intact ventricular myocytes at low and high affinity Ca2+-calmodulin targets.

1Intracellular Na$^+$ concentration is elevated in heart failure but Na/K pump function is unchanged.

1Genetic manipulation of calcium-handling proteins in cardiac myocytes. II. Mathematical modeling studies.

1Na/K pump-induced Na(i) gradients in rat ventricular myocytes measured with two-photon microscopy.

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publications (hide)11 displayallpublications onlypublications per page5102050100 sort byadded attitleauthorpublication dateentry typehelp for advanced sorting... RSSBibTeXRDFmore...

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publications (hide)11
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