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1Agonist-dependent delivery of M(2) muscarinic acetylcholine receptors to the cell surface after pertussis toxin treatment
A. Roseberry, M. Bunemann, J. Elavunkal, and M. Hosey. Mol Pharmacol, 59 (5): 1256-68 (May 2001)Roseberry, A G Bunemann, M Elavunkal, J Hosey, M M HL50121/HL/NHLBI NIH HHS/United States T32-GM08061/GM/NIGMS NIH HHS/United States Research Support, U.S. Gov't, P.H.S. United States Molecular pharmacology Mol Pharmacol. 2001 May;59(5):1256-68..
14 years ago by @pharmawuerz
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Heterotrimeric
Phosphorylation/drug
Transport/drug
Agonists/*pharmacology
Biological
Protein
effects
Toxin
Receptor
Inhibitors/pharmacology
*Pertussis
Interactions
Brefeldin
Surface/metabolism
M2
Humans
Virulence
Bordetella/*pharmacology
Muscarinic
A/pharmacology
Proteins/metabolism
Muscarinic/*metabolism
Factors,
Synthesis
alpha
GTP-Binding
Gi-Go/metabolism
Cultured
Golgi
Apparatus/metabolism
Cell
Subunits,
Drug
HeterotrimericPhosphorylation/drugTransport/drugAgonists/*pharmacologyBiologicalProteineffectsToxinReceptorInhibitors/pharmacology*PertussisInteractionsBrefeldinSurface/metabolismM2HumansVirulenceBordetella/*pharmacologyMuscarinicA/pharmacologyProteins/metabolismMuscarinic/*metabolismFactors,SynthesisalphaGTP-BindingGi-Go/metabolismCulturedGolgiApparatus/metabolismCellSubunits,Drug
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1Molecular events associated with the regulation of signaling by M2 muscarinic receptors
M. Hosey, R. Pals-Rylaarsdam, K. Lee, A. Roseberry, J. Benovic, V. Gurevich, and M. Bunemann. Life Sci, 64 (6-7): 363-8 (1999)Hosey, M M Pals-Rylaarsdam, R Lee, K B Roseberry, A G Benovic, J L Gurevich, V V Bunemann, M EY11500/EY/NEI NIH HHS/United States GM44944/GM/NIGMS NIH HHS/United States HL 50121/HL/NHLBI NIH HHS/United States etc. Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. England Life sciences Life Sci. 1999;64(6-7):363-8..
14 years ago by @pharmawuerz
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*GTPase-Activating
Dominant/genetics/physiology
Inwardly-Rectifying
effects
Toxin
Line
Down-Regulation/drug
M2
Humans
Adenylate
Bordetella/pharmacology
Channels
Factors,
Substitution
Muscarinic/genetics/*metabolism
Cell
*Potassium
Barium/pharmacology
&
Blockers
Proteins/antagonists
Channel
inhibitors/*metabolism
Genes,
Proteins/genetics/physiology
Channels,
Protein
beta-Adrenergic
Carbachol/pharmacology
Cyclase
Receptor
Cyclic
Transduction
Potassium
Acid
Phosphorylation
G
Virulence
*RGS
Arrestins/metabolism
Muscarinic
Transfection
Inwardly
Proteins
*Signal
Kinases
Protein-Coupled
Kinases/genetics/physiology
Rectifying
GTP-Binding
Channels/genetics/metabolism
Amino
AMP-Dependent
*GTPase-ActivatingDominant/genetics/physiologyInwardly-RectifyingeffectsToxinLineDown-Regulation/drugM2HumansAdenylateBordetella/pharmacologyChannelsFactors,SubstitutionMuscarinic/genetics/*metabolismCell*PotassiumBarium/pharmacology&BlockersProteins/antagonistsChannelinhibitors/*metabolismGenes,Proteins/genetics/physiologyChannels,Proteinbeta-AdrenergicCarbachol/pharmacologyCyclaseReceptorCyclicTransductionPotassiumAcidPhosphorylationGVirulence*RGSArrestins/metabolismMuscarinicTransfectionInwardlyProteins*SignalKinasesProtein-CoupledKinases/genetics/physiologyRectifyingGTP-BindingChannels/genetics/metabolismAminoAMP-Dependent
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1Downregulation of muscarinic M2 receptors linked to K+ current in cultured guinea-pig atrial myocytes
M. Bunemann, B. Brandts, and L. Pott. J Physiol, (July 1996)Bunemann, M Brandts, B Pott, L Research Support, Non-U.S. Gov't England The Journal of physiology J Physiol. 1996 Jul 15;494 ( Pt 2):351-62..
14 years ago by @pharmawuerz
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Pigs
Down-Regulation
Acetylcholine/pharmacology
Contraction/drug
Heart/*physiology
effects
Animals
Receptor
Carbachol/pharmacology
Myocardium/metabolism
Kinetics
Transduction
effects/*physiology
Potassium
Potentials/drug
Heart
Guinea
M2
Male
Muscarinic
Muscarinic/*biosynthesis
Channels/drug
Myocardial
Membrane
Cultured
Atria
Signal
Female
Cell
PigsDown-RegulationAcetylcholine/pharmacologyContraction/drugHeart/*physiologyeffectsAnimalsReceptorCarbachol/pharmacologyMyocardium/metabolismKineticsTransductioneffects/*physiologyPotassiumPotentials/drugHeartGuineaM2MaleMuscarinicMuscarinic/*biosynthesisChannels/drugMyocardialMembraneCulturedAtriaSignalFemaleCell
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1In vivo downregulation of M2 receptors revealed by measurement of muscarinic K+ current in cultured guinea-pig atrial myocytes
M. Bunemann, B. Brandts, and L. Pott. J Physiol, (June 1997)Bunemann, M Brandts, B Pott, L Research Support, Non-U.S. Gov't England The Journal of physiology J Physiol. 1997 Jun 15;501 ( Pt 3):549-54..
14 years ago by @pharmawuerz
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Pigs
Agonists/pharmacology
Ion
Transport/drug
Down-Regulation
Acetylcholine/pharmacology
Vagus
effects
Nerve/physiology
Animals
Receptor
Carbachol/pharmacology
Kinetics
effects/metabolism
effects/*metabolism
Muscarinic/drug
Potassium/*metabolism
Atria/cytology/drug
Heart
Guinea
M2
Muscarinic
Myocardium/cytology/*metabolism
Cultured
Cell
PigsAgonists/pharmacologyIonTransport/drugDown-RegulationAcetylcholine/pharmacologyVaguseffectsNerve/physiologyAnimalsReceptorCarbachol/pharmacologyKineticseffects/metabolismeffects/*metabolismMuscarinic/drugPotassium/*metabolismAtria/cytology/drugHeartGuineaM2MuscarinicMyocardium/cytology/*metabolismCulturedCell
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1Overexpressed A(1) adenosine receptors reduce activation of acetylcholine-sensitive K(+) current by native muscarinic M(2) receptors in rat atrial myocytes
M. Wellner-Kienitz, K. Bender, T. Meyer, M. Bunemann, and L. Pott. Circ Res, 86 (6): 643-8 (March 2000)Wellner-Kienitz, M C Bender, K Meyer, T Bunemann, M Pott, L Research Support, Non-U.S. Gov't United states Circulation research Circ Res. 2000 Mar 31;86(6):643-8..
14 years ago by @pharmawuerz
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Heart
M2
WKY
Muscarinic/*physiology
Male
Conductivity
Electric
Purinergic
Rats
Muscarinic
Transfection
Channels/drug
Animals
Myocardium/cytology/*metabolism
Receptor
Acetylcholine/pharmacology/*physiology
effects/*physiology
Mice
Adenosine/pharmacology
Atria
Potassium
P1/*metabolism
Female
HeartM2WKYMuscarinic/*physiologyMaleConductivityElectricPurinergicRatsMuscarinicTransfectionChannels/drugAnimalsMyocardium/cytology/*metabolismReceptorAcetylcholine/pharmacology/*physiologyeffects/*physiologyMiceAdenosine/pharmacologyAtriaPotassiumP1/*metabolismFemale
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1Novel signalling events mediated by muscarinic receptor subtypes
M. Bunemann, and M. Hosey. Life Sci, 68 (22-23): 2525-33 (April 2001)Bunemann, M Hosey, M M HL50121/HL/NHLBI NIH HHS/United States Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. England Life sciences Life Sci. 2001 Apr 27;68(22-23):2525-33..
14 years ago by @pharmawuerz
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Patch-Clamp
Cricetinae
Heterotrimeric
Techniques
5'-O-(3-Thiotriphosphate)/pharmacology
Acetylcholine/pharmacology
Channels,
Transduction/drug
Channels/genetics/*metabolism
Inwardly-Rectifying
Animals
Receptor
effects/*physiology
Potassium
Calcium
M2
Humans
M3
G
M4
Guanosine
CHO
Purinergic
Muscarinic
N-Type/metabolism
Transfection
Inwardly
Proteins/metabolism
Channels
Protein-Coupled
P1/metabolism
GTP-Binding
Muscarinic/genetics/*metabolism
Cultured
Rectifying
Signal
Cell
*Potassium
Patch-ClampCricetinaeHeterotrimericTechniques5'-O-(3-Thiotriphosphate)/pharmacologyAcetylcholine/pharmacologyChannels,Transduction/drugChannels/genetics/*metabolismInwardly-RectifyingAnimalsReceptoreffects/*physiologyPotassiumCalciumM2HumansM3GM4GuanosineCHOPurinergicMuscarinicN-Type/metabolismTransfectionInwardlyProteins/metabolismChannelsProtein-CoupledP1/metabolismGTP-BindingMuscarinic/genetics/*metabolismCulturedRectifyingSignalCell*Potassium
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1G-protein coupled receptor kinases as modulators of G-protein signalling
M. Bunemann, and M. Hosey. J Physiol, (May 1999)Bunemann, M Hosey, M M Review England The Journal of physiology J Physiol. 1999 May 15;517 ( Pt 1):5-23..
14 years ago by @pharmawuerz
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M2
Protein-Tyrosine
Muscarinic/metabolism
Humans
Biological
Muscarinic
Adrenergic
Surface/*metabolism
Proteins/metabolism
Protein
Kinases/chemistry/*metabolism
beta-2/metabolism
Animals
Receptor
Arrestin/metabolism
GTP-Binding
Transduction
Models,
Endocytosis
Signal
Cell
Conformation
M2Protein-TyrosineMuscarinic/metabolismHumansBiologicalMuscarinicAdrenergicSurface/*metabolismProteins/metabolismProteinKinases/chemistry/*metabolismbeta-2/metabolismAnimalsReceptorArrestin/metabolismGTP-BindingTransductionModels,EndocytosisSignalCellConformation
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1Acidic amino acids flanking phosphorylation sites in the M2 muscarinic receptor regulate receptor phosphorylation, internalization, and interaction with arrestins
K. Lee, J. Ptasienski, M. Bunemann, and M. Hosey. J Biol Chem, 275 (46): 35767-77 (November 2000)Lee, K B Ptasienski, J A Bunemann, M Hosey, M M HL50121/HL/NHLBI NIH HHS/United States T32GM08061/GM/NIGMS NIH HHS/United States Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. United states The Journal of biological chemistry J Biol Chem. 2000 Nov 17;275(46):35767-77..
14 years ago by @pharmawuerz
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Mutagenesis/genetics
Binding
Precipitin
Phosphorylation/drug
Data
Concentration
Sequence
Carbachol/metabolism/pharmacology
Protein
effects
Animals
Receptor
Inhibitory
Line
Substitution/genetics
*Endocytosis
Acid
M2
Acids/*metabolism
Humans
Muscarinic/*chemistry/genetics/*metabolism
Agonists/metabolism/pharmacology
Muscarinic
Transfection
Arrestins/chemistry/genetics/*metabolism
Cholinergic
Tests
Molecular
Amino
50
Cell
Mutagenesis/geneticsBindingPrecipitinPhosphorylation/drugDataConcentrationSequenceCarbachol/metabolism/pharmacologyProteineffectsAnimalsReceptorInhibitoryLineSubstitution/genetics*EndocytosisAcidM2Acids/*metabolismHumansMuscarinic/*chemistry/genetics/*metabolismAgonists/metabolism/pharmacologyMuscarinicTransfectionArrestins/chemistry/genetics/*metabolismCholinergicTestsMolecularAmino50Cell
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publications (hide)8 displayallpublications onlypublications per page5102050100 sort byadded attitleauthorpublication dateentry typehelp for advanced sorting... RSSBibTeXRDFmore...

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publications (hide)8
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