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1Size matters: just how big is BIG?: Quantifying realistic sample size requirements for human genome epidemiology.
P. Burton, A. Hansell, I. Fortier, T. Manolio, M. Khoury, J. Little, and P. Elliott. International journal of epidemiology, 38 (1): 263-73 (February 2009)4935<m:linebreak></m:linebreak>GR: 075883/Wellcome Trust/United Kingdom; GR: G9806740/Medical Research Council/United Kingdom; JID: 7802871; CIN: Int J Epidemiol. 2009 Feb;38(1):274-5. PMID: 18984600; OID: NLM: PMC2639365; 2008/08/01 aheadofprint; 2008/08/25 aheadofprint; ppublish;<m:linebreak></m:linebreak>Epidemiologia genètica.
2 years ago by @jepcastel
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Disease
ResearchDesign
Humans
ChronicDisease:epidemiology
Genomics
Male
Genomics:methods
ChronicDisease
SampleSize
Case-ControlStudies
BiologicalSpecimenBanks
Disease:genetics
GeneticPredispositiontoDisease
Adult
Aged
LifeStyle
Female
MiddleAged
DiseaseResearchDesignHumansChronicDisease:epidemiologyGenomicsMaleGenomics:methodsChronicDiseaseSampleSizeCase-ControlStudiesBiologicalSpecimenBanksDisease:geneticsGeneticPredispositiontoDiseaseAdultAgedLifeStyleFemaleMiddleAged
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1The association of aspirin use with age-related macular degeneration.
G. Liew, P. Mitchell, T. Wong, E. Rochtchina, and J. Wang. JAMA internal medicine, 173 (4): 258-64 (February 2013)JID: 101589534; ppublish;<m:linebreak></m:linebreak> <m:linebreak></m:linebreak>Causalitat; Exemple.
2 years ago by @jepcastel
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Australia
Aspirin
80andover
Aspirin:administration&dosage
CardiovascularDiseases:prevention&control
Humans
MacularDegeneration:epidemiology
Male
Incidence
LogisticModels
ProspectiveStudies
CardiovascularDiseases:drugtherapy
MacularDegeneration:classification
Aspirin:adverseeffects
RiskFactors
MacularDegeneration
Smoking
CohortStudies
Aged
MacularDegeneration:etiology
Female
CardiovascularDiseases
MiddleAged
AustraliaAspirin80andoverAspirin:administration&dosageCardiovascularDiseases:prevention&controlHumansMacularDegeneration:epidemiologyMaleIncidenceLogisticModelsProspectiveStudiesCardiovascularDiseases:drugtherapyMacularDegeneration:classificationAspirin:adverseeffectsRiskFactorsMacularDegenerationSmokingCohortStudiesAgedMacularDegeneration:etiologyFemaleCardiovascularDiseasesMiddleAged
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1Comparative Analysis of the Impact of Climate Change on Male and Female Mental Health
J. Ulaetor. International Journal of Trend in Scientific Research and Development, 4 (2): 792-806 (February 2020)
5 years ago by @ijtsrd
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psychiatric
patients
Relative
Temperature
Humidity
and
Male
female
psychiatricpatientsRelativeTemperatureHumidityandMalefemale
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1Common variants associated with breast cancer in genome-wide association studies are modifiers of breast cancer risk in BRCA1 and BRCA2 mutation carriers
X. Wang, V. Pankratz, Z. Fredericksen, R. Tarrell, M. Karaus, L. McGuffog, Pharaoh, Paul D P, Ponder, Bruce A J, A. Dunning, S. Peock and 34 other author(s). Human molecular genetics, 19 (14): 2886–2897 (2010)
10 years ago by @drtester
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Middle_Aged
Humans
Mutation/physiology
Genetic_Loci/physiology
Genotype
Carcinoma/genetics
Risk_Factors
Genome-Wide_Association_Study
Genetic_Predisposition_to_Disease
Epistasis,_Genetic/physiology
Breast_Neoplasms/genetics
Heterozygote
Polymorphism,_Single_Nucleotide/physiology
Genes,_BRCA2
Adult
Genes,_BRCA1
Gene_Frequency
Female
Middle_AgedHumansMutation/physiologyGenetic_Loci/physiologyGenotypeCarcinoma/geneticsRisk_FactorsGenome-Wide_Association_StudyGenetic_Predisposition_to_DiseaseEpistasis,_Genetic/physiologyBreast_Neoplasms/geneticsHeterozygotePolymorphism,_Single_Nucleotide/physiologyGenes,_BRCA2AdultGenes,_BRCA1Gene_FrequencyFemale
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1Common breast cancer susceptibility alleles are associated with tumour subtypes in BRCA1 and BRCA2 mutation carriers: results from the Consortium of Investigators of Modifiers of BRCA1/2
A. Mulligan, F. Couch, D. Barrowdale, S. Domchek, D. Eccles, H. Nevanlinna, S. Ramus, M. Robson, M. Sherman, A. Spurdle and 172 other author(s). Breast cancer research : BCR, 13 (6): R110 (2011)
10 years ago by @drtester
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Receptors,_Estrogen/metabolism
Humans
Risk
Polymorphism,_Single_Nucleotide
Breast_Neoplasms/classification/genetics/metabolism
Genetic_Predisposition_to_Disease
Alleles
Heterozygote
Genes,_BRCA2
Genes,_BRCA1
Mutation
Receptors,_Progesterone/metabolism
Female
Receptors,_Estrogen/metabolismHumansRiskPolymorphism,_Single_NucleotideBreast_Neoplasms/classification/genetics/metabolismGenetic_Predisposition_to_DiseaseAllelesHeterozygoteGenes,_BRCA2Genes,_BRCA1MutationReceptors,_Progesterone/metabolismFemale
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1A locus on 19p13 modifies risk of breast cancer in BRCA1 mutation carriers and is associated with hormone receptor-negative breast cancer in the general population
A. Antoniou, X. Wang, Z. Fredericksen, L. McGuffog, R. Tarrell, O. Sinilnikova, S. Healey, J. Morrison, C. Kartsonaki, T. Lesnick and 168 other author(s). Nature genetics, 42 (10): 885–892 (2010)
10 years ago by @drtester
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Receptors,_Estrogen/genetics
Humans
Receptor,_erbB-2/genetics
Genotype
BRCA1_Protein/genetics
Receptors,_Progesterone/genetics
Polymorphism,_Single_Nucleotide/genetics
Genetic_Predisposition_to_Disease
Case-Control_Studies
Chromosomes,_Human,_Pair_19/genetics
Mutation/genetics
Adult
Breast_Neoplasms/genetics/pathology
Female
Receptors,_Estrogen/geneticsHumansReceptor,_erbB-2/geneticsGenotypeBRCA1_Protein/geneticsReceptors,_Progesterone/geneticsPolymorphism,_Single_Nucleotide/geneticsGenetic_Predisposition_to_DiseaseCase-Control_StudiesChromosomes,_Human,_Pair_19/geneticsMutation/geneticsAdultBreast_Neoplasms/genetics/pathologyFemale
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1Common alleles at 6q25.1 and 1p11.2 are associated with breast cancer risk for BRCA1 and BRCA2 mutation carriers
A. Antoniou, C. Kartsonaki, O. Sinilnikova, P. Soucy, L. McGuffog, S. Healey, A. Lee, P. Peterlongo, S. Manoukian, B. Peissel and 169 other author(s). Human molecular genetics, 20 (16): 3304–3321 (2011)
10 years ago by @drtester
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Middle_Aged
Chromosomes,_Human/genetics
Humans
Risk_Factors
Chromosomes,_Human,_Pair_6/genetics
BRCA1_Protein/genetics
Polymorphism,_Single_Nucleotide/genetics
Chromosomes,_Human,_Pair_1/genetics
Genetic_Predisposition_to_Disease
Alleles
Breast_Neoplasms/genetics
Heterozygote
Mutation/genetics
Adult
Aged
BRCA2_Protein/genetics
Female
Middle_AgedChromosomes,_Human/geneticsHumansRisk_FactorsChromosomes,_Human,_Pair_6/geneticsBRCA1_Protein/geneticsPolymorphism,_Single_Nucleotide/geneticsChromosomes,_Human,_Pair_1/geneticsGenetic_Predisposition_to_DiseaseAllelesBreast_Neoplasms/geneticsHeterozygoteMutation/geneticsAdultAgedBRCA2_Protein/geneticsFemale
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119p13.1 is a triple-negative-specific breast cancer susceptibility locus
K. Stevens, Z. Fredericksen, C. Vachon, X. Wang, S. Margolin, A. Lindblom, H. Nevanlinna, D. Greco, K. Aittomäki, C. Blomqvist and 144 other author(s). Cancer research, 72 (7): 1795–1803 (2012)
10 years ago by @drtester
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Genetic_Predisposition_to_Disease
Chromosome_Mapping
Breast_Neoplasms/chemistry/genetics
Chromosomes,_Human,_Pair_19
Humans
Receptors,_Progesterone/analysis
Risk
Genetic_Loci
Female
Receptor,_erbB-2/analysis
Receptors,_Estrogen/analysis
Genetic_Predisposition_to_DiseaseChromosome_MappingBreast_Neoplasms/chemistry/geneticsChromosomes,_Human,_Pair_19HumansReceptors,_Progesterone/analysisRiskGenetic_LociFemaleReceptor,_erbB-2/analysisReceptors,_Estrogen/analysis
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1Ovarian cancer susceptibility alleles and risk of ovarian cancer in BRCA1 and BRCA2 mutation carriers
S. Ramus, A. Antoniou, K. Kuchenbaecker, P. Soucy, J. Beesley, X. Chen, L. McGuffog, O. Sinilnikova, S. Healey, D. Barrowdale and 176 other author(s). Human mutation, 33 (4): 690–702 (2012)
10 years ago by @drtester
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Middle_Aged
Humans
Polymorphism,_Single_Nucleotide
Retrospective_Studies
BRCA1_Protein/genetics
Genetic_Predisposition_to_Disease
Cohort_Studies
Heterozygote
Ovarian_Neoplasms/genetics
Odds_Ratio
Adult
Mutation
BRCA2_Protein/genetics
Female
Middle_AgedHumansPolymorphism,_Single_NucleotideRetrospective_StudiesBRCA1_Protein/geneticsGenetic_Predisposition_to_DiseaseCohort_StudiesHeterozygoteOvarian_Neoplasms/geneticsOdds_RatioAdultMutationBRCA2_Protein/geneticsFemale
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1Functional variants at the 11q13 risk locus for breast cancer regulate cyclin D1 expression through long-range enhancers
J. French, M. Ghoussaini, S. Edwards, K. Meyer, K. Michailidou, S. Ahmed, S. Khan, M. Maranian, M. O'Reilly, K. Hillman and 201 other author(s). American journal of human genetics, 92 (4): 489–503 (2013)
10 years ago by @drtester
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Cell_Line,_Tumor
Cyclin_D1/genetics/metabolism
RNA,_Small_Interfering/genetics
RNA,_Messenger/genetics
Enhancer_Elements,_Genetic/genetics
Chromosomes,_Human,_Pair_11/genetics
Humans
Chromatin/chemistry/genetics
Real-Time_Polymerase_Chain_Reaction
Silencer_Elements,_Transcriptional/genetics
Polymorphism,_Single_Nucleotide/genetics
Luciferases/metabolism
Gene_Expression_Regulation,_Neoplastic
Case-Control_Studies
Breast_Neoplasms/genetics
Chromatin_Immunoprecipitation
GATA3_Transcription_Factor/antagonists_&_inhibitors/genetics/metabolism
Electrophoretic_Mobility_Shift_Assay
Promoter_Regions,_Genetic/genetics
ets-Domain_Protein_Elk-4/antagonists_&_inhibitors/genetics/metabolism
Binding_Sites
Female
Reverse_Transcriptase_Polymerase_Chain_Reaction
Cell_Line,_TumorCyclin_D1/genetics/metabolismRNA,_Small_Interfering/geneticsRNA,_Messenger/geneticsEnhancer_Elements,_Genetic/geneticsChromosomes,_Human,_Pair_11/geneticsHumansChromatin/chemistry/geneticsReal-Time_Polymerase_Chain_ReactionSilencer_Elements,_Transcriptional/geneticsPolymorphism,_Single_Nucleotide/geneticsLuciferases/metabolismGene_Expression_Regulation,_NeoplasticCase-Control_StudiesBreast_Neoplasms/geneticsChromatin_ImmunoprecipitationGATA3_Transcription_Factor/antagonists_&_inhibitors/genetics/metabolismElectrophoretic_Mobility_Shift_AssayPromoter_Regions,_Genetic/geneticsets-Domain_Protein_Elk-4/antagonists_&_inhibitors/genetics/metabolismBinding_SitesFemaleReverse_Transcriptase_Polymerase_Chain_Reaction
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1Genome-wide association study in BRCA1 mutation carriers identifies novel loci associated with breast and ovarian cancer risk
F. Couch, X. Wang, L. McGuffog, A. Lee, C. Olswold, K. Kuchenbaecker, P. Soucy, Z. Fredericksen, D. Barrowdale, J. Dennis and 252 other author(s). PLoS genetics, 9 (3): e1003212 (2013)
10 years ago by @drtester
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Middle_Aged
Prognosis
Humans
Genotype
Polymorphism,_Single_Nucleotide
Risk_Factors
Genome-Wide_Association_Study
BRCA1_Protein/genetics
Genetic_Predisposition_to_Disease
Ovarian_Neoplasms/genetics/pathology
Heterozygote
Mutation
Breast_Neoplasms/genetics/pathology
BRCA2_Protein/genetics
Female
Middle_AgedPrognosisHumansGenotypePolymorphism,_Single_NucleotideRisk_FactorsGenome-Wide_Association_StudyBRCA1_Protein/geneticsGenetic_Predisposition_to_DiseaseOvarian_Neoplasms/genetics/pathologyHeterozygoteMutationBreast_Neoplasms/genetics/pathologyBRCA2_Protein/geneticsFemale
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1Common variants at the 19p13.1 and ZNF365 loci are associated with ER subtypes of breast cancer and ovarian cancer risk in BRCA1 and BRCA2 mutation carriers
F. Couch, M. Gaudet, A. Antoniou, S. Ramus, K. Kuchenbaecker, P. Soucy, J. Beesley, X. Chen, X. Wang, T. Kirchhoff and 180 other author(s). Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 21 (4): 645–657 (2012)
10 years ago by @drtester
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Middle_Aged
Prognosis
Ovarian_Neoplasms/epidemiology/genetics/metabolism
Receptors,_Estrogen/metabolism
Breast_Neoplasms/epidemiology/genetics/metabolism
Humans
United_States/epidemiology
Genotype
Risk_Factors
DNA-Binding_Proteins/genetics
Genome-Wide_Association_Study
BRCA1_Protein/genetics
Polymorphism,_Single_Nucleotide/genetics
Genetic_Predisposition_to_Disease
Immunoenzyme_Techniques
Chromosomes,_Human,_Pair_19/genetics
Transcription_Factors/genetics
Mutation/genetics
Adult
Aged
BRCA2_Protein/genetics
Female
Middle_AgedPrognosisOvarian_Neoplasms/epidemiology/genetics/metabolismReceptors,_Estrogen/metabolismBreast_Neoplasms/epidemiology/genetics/metabolismHumansUnited_States/epidemiologyGenotypeRisk_FactorsDNA-Binding_Proteins/geneticsGenome-Wide_Association_StudyBRCA1_Protein/geneticsPolymorphism,_Single_Nucleotide/geneticsGenetic_Predisposition_to_DiseaseImmunoenzyme_TechniquesChromosomes,_Human,_Pair_19/geneticsTranscription_Factors/geneticsMutation/geneticsAdultAgedBRCA2_Protein/geneticsFemale
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1Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer
S. Bojesen, K. Pooley, S. Johnatty, J. Beesley, K. Michailidou, J. Tyrer, S. Edwards, H. Pickett, H. Shen, C. Smart and 427 other author(s). Nature genetics, 45 (4): 371-84, 384e1-2 (2013)
10 years ago by @drtester
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RNA,_Messenger/genetics
Oligonucleotide_Array_Sequence_Analysis
Humans
Telomere/genetics
Genotype
Real-Time_Polymerase_Chain_Reaction
Risk_Factors
Genetic_Loci/genetics
Genome-Wide_Association_Study
Polymorphism,_Single_Nucleotide/genetics
Genetic_Predisposition_to_Disease
Gene_Expression_Profiling
Luciferases/metabolism
Ovarian_Neoplasms/etiology/pathology
Case-Control_Studies
Alternative_Splicing
Chromatin/genetics
Telomerase/genetics
DNA_Methylation
Breast_Neoplasms/etiology/pathology
Tumor_Markers,_Biological/genetics
Female
Reverse_Transcriptase_Polymerase_Chain_Reaction
RNA,_Messenger/geneticsOligonucleotide_Array_Sequence_AnalysisHumansTelomere/geneticsGenotypeReal-Time_Polymerase_Chain_ReactionRisk_FactorsGenetic_Loci/geneticsGenome-Wide_Association_StudyPolymorphism,_Single_Nucleotide/geneticsGenetic_Predisposition_to_DiseaseGene_Expression_ProfilingLuciferases/metabolismOvarian_Neoplasms/etiology/pathologyCase-Control_StudiesAlternative_SplicingChromatin/geneticsTelomerase/geneticsDNA_MethylationBreast_Neoplasms/etiology/pathologyTumor_Markers,_Biological/geneticsFemaleReverse_Transcriptase_Polymerase_Chain_Reaction
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publications (hide)13
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